Dipeptide uptake and transport characteristics in rabbit tracheal epithelial cell layers cultured at an air interface

Pharmaceutical Research

Volumn 15, Issue 7, 1998, Pages 979-983

  Yamashita, Fumiyoshi ^a   Kim, Kwang Jin ^a,b   Lee, Vincent H L ^a,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Depts Med Physiol Biophys B

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Carnosine; Peptide transporter; Tracheal epithelial cell layer; Transport

Indexed keywords

CARNOSINE; DIPEPTIDE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CULTURE MEDIUM; DOSE RESPONSE; EPITHELIUM CELL; ISOTOPE LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; RABBIT; TRACHEA MUCOSA;

ANIMALS; BIOLOGICAL TRANSPORT; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CARNOSINE; CELLS, CULTURED; EPITHELIAL CELLS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IONOPHORES; KINETICS; RABBITS; TRACHEA;

EID: 0031818881     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011957506181     Document Type: Article

References (29)

1. + coupled uphill transport of aminocephalosporins via the dipeptide transport system in rabbit intestinal brush-border membranes. J. Biol. Chem. 261:14130-14134 (1986).
2. A. Tsuji, I. Tamai, H. Hirooka, and T. Terasaki. Beta-lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane. Biochem. Pharmacol. 36:565-567 (1987).
3. + symporter. J. Clin. Invest. 92:2215-2223 (1993).
4. M. Hu and G. L. Amidon. Passive and carrier mediated intestinal absorption components of captopril. J. Pharm. Sci. 77:1007-1011 (1988).
5. W. Kramer, F. Girbig, U. Gutjahr, H. W. Kleeman, I. Leipe, H. Urbach, and A. Wagner. Interaction of renin inhibitors with the intestinal uptake system for oligopeptides and β-lactam antibiotics. Biochim. Biophys. Acta 1027:25-30 (1990).
6. P. A. Heiltiwell, D. Merdith, C. A. R. Boyd, J. R. Bronk, N. Lister, and P. D. Bailey. Tripeptide transport in rat lung. Biochim. Biophys. Acta 1190:430-434 (1994).
7. D. Meredith and C. A. R. Boyd. Dipeptide transport characteristics of the apical membrane of rat lung type II pneumocytes. Am. J. Physiol. 269:L137-L143 (1995).
8. K. Morimoto, H. Yamahara, V. H. L. Lee, and K. J. Kim. Dipeptide transport across rat alveolar epithelial cell monolayers. Pharm. Res. 10:1668-1674 (1993).
9. R. G. Breeze and E. B. Wheeldon. The cells of the pulmonary airways. Am. Rev. Respir. Dis. 116:705-777 (1997).
10. S. I. Rennard, J. D. Beckmann, and R. A. Robbins. Biology of airway epithelial cells. In R. G. Crystal, J. B. West, P. J. Barnes, N. S. Cherniack, and E. R. Weibel (eds.), THE LUNG: Scientific Foundations, Raven Press, New York, 1991, pp. 157-167.
11. D. M. Matthews, J. M. Addison, and D. Burston. Evidence for active transport of the dipeptide carnosine (β-alanyl-L-histidine) by hamster jejunum in vitro. Clin. Sci. Mol. Med. 46:693-705 (1974).
12. V. Ganapathy and F. H. Leibach. Peptide transport in rabbit kidney: study with L-carnosine. Biochim. Biophvs. Acta 691:362-366 (1982).
13. V. Ganapathy and F. H. Leibach. Role of pH gradient and membrane potential in dipeptide transport in intestinal and renal brush-border membrane vesicles from the rabbit: study with L-carnosine and glycyl-L-proline. J. Biol. Chem. 10:14189-14192 (1983).
14. V. M. Rajendran, A. Berteloot, Y. Ishikawa, A. H. Khan, and K. Ramaswamy. Transport of carnosine by mouse intestinal brush-border membrane vesicles. Biochim. Biophys. Acta 778: 443-448 (1984).
15. N. R. Mathias, T. W. Robison, K. J. Kim, and V. H. L. Lee. Development and characterization of rabbit tracheal epithelial cell culture models for drug transport studies. Pharm. Res. 12: 1499-1505 (1995).
16. K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn. 4:879-885 (1981).
17. F. Yamashita, K. J. Kim, and V. H. L. Lee. Gly-L-Phe transport and metabolism across primary cultured rabbit tracheal epithelial cell monolayers. Pharm. Res. 14:238-240 (1997).
18. + symporter in the renal brush border membrane. J. Biol. Chem. 267:9565-9573 (1992).
19. + exchanger in isolated epithelial tracheal cells from sheep. Involvement in tracheal proton secretion. Exp. Physiol. 78:383-394 (1993).
20. + exchange in human normal and cystic fibrotic ciliated airway epithelium. Am. J. Physiol. 262:L757-L764 (1992).
21. J. G. Widdicombe. Airway mucus. Eur. Respir. J. 2:107-115 (1989).
22. +/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2). Biochim. Biophys. Acta 1324:251-262 (1997).
23. I. Naasani, K. Sato, K. Iseki, M. Sugawara, M. Kobayashi, and K. Miyazaki. Comparison of the transport characteristics of ceftibuten in rat renal and intestinal brush-border membranes. Biochim. Biophys. Acta 1231:163-168 (1995).
24. +/peptide cotransporter family, from human kidney. Biochim. Biophys. Acta 1235:461-466 (1995).
25. M. Boll, M. Herget, M. Wagener, W. M. Weber, D. Markovich, J. Biber, W. Clauss, H. Murer, and H. Daniel. Expression cloning and functional characterization of the kidney cortex high-affinity proton-coupled peptide transporter. Proc. Natl. Acad. Sci. USA 93:284-289 (1996).
26. H. Saito, T. Terada, M. Okuda, S. Sasaki, and K. Inui. Molecular cloning and tissue distribution of rat peptide transporter PEPT2. Biochim. Biophys. Acta 1280:173-177 (1996).
27. D. E. Goldman. Potential, impedance, and rectification in membranes. J. Gen. Physiol 27:37-60 (1943).
28. K. Inui, M. Yamamoto, and H. Saito. Transepithelial transport of oral cephalosporins by monolayers of intestinal epithelial cell line Caco-2: Specific transport systems in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 261:195-201 (1992).
29. S. Matsumoto, H. Saito, and K. Inui. Transcellular transport of oral cephalosporins in human intestinal epithelial cells, Caco-2: Interaction with dipeptide transport systems in apical and basolateral membranes. J. Pharmacol. Exp. Ther. 270:498-504 (1994).