Enhancement of the discriminative stimulus effects of phencyclidine by the tetracycline antibiotics doxycycline and minocycline in rats

Psychopharmacology

Volumn 160, Issue 3, 2002, Pages 331-336

  Munzar, Patrik ^a   Li, Hua ^a   Nicholson, Katherine L ^a   Wiley, Jenny L ^a   Balster, Robert L ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Doxycycline; Drug discrimination; Minocycline; MK 801; PCP

Indexed keywords

ANTIBIOTIC AGENT; DIZOCILPINE; DOXYCYCLINE; MINOCYCLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; TETRACYCLINE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN DISEASE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISCRIMINATIVE STIMULUS; DOSE RESPONSE; DRUG ACTIVATION; DRUG EFFECT; DRUG SCREENING; FOOD; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; STIMULUS RESPONSE;

ANIMALS; ANTI-BACTERIAL AGENTS; DISCRIMINATION (PSYCHOLOGY); DOXYCYCLINE; DRUG SYNERGISM; EXCITATORY AMINO ACID ANTAGONISTS; MALE; MINOCYCLINE; PHENCYCLIDINE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036124542     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-001-0989-7     Document Type: Article

References (36)

1. A novel mechanim of action of tetracyclines: Effects on nitric oxide synthases
2. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines
3. Discriminative stimulus properties of phencyclidine and other NMDA antagonists
4. Phencyclidine: A drug of abuse and a tool for neuroscience research
5. Blockade of phencyclidine-induced effects by a nitric oxide donor
6. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease
7. Reduction of central nervous system reperfusion injury in rabbits using doxycycline treatment
8. Minocycline versus doxycycline in the treatment of lyme neuroborreliosis
9. Distressing side-effects of minocycline hydrochloride
10. Prediction of the pharmacokinetic profiles of doxycycline in humans based on the results of experiments in animals
11. Interference with human memory by an antibiotic
12. Nitric oxide synthase inhibitors produce phencyclidine-like behavioral effects in pigeons
13. Tetracyclines
14. Inhibition by antibiotic tetra-cyclines of rat cortical noradrenergic adenylate cyclase and amphetamine-induced hyperactivity
15. Central and peripheral minocycline suppresses motor activity in rats
16. Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory
17. Inducible and reversible gene expression with the rtTA system for the study of memory
18. Control of memory formation through regulated expression of a CaMKII transgene
19. Effects of minocycline on accumulation of cyclic AMP in cerebral cortex of rat. A comparison with lithium
20. Effects of various serotonin agonists, antagonists, and uptake inhibitors on the discriminative stimulus effects of methamphetamine in rats
21. Evaluation of the reinforcing properties and phencyclidine-like discriminative stimulus effects of dextromethorphan and dextrorphan in rats and rhesus monkeys
22. Glutamate in CNS disorders as a target for drug development: An update
23. Doxycycline reduces early neurologic impairment after cerebral arterial air embolism in the rabbit
24. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction
25. NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
26. The tetracyclines
27. Minocycline provides neuroprotection against n-methyl-d-aspartate neurotoxicity by inhibiting microglia
28. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
29. Behavioral pharmacology of N-methyl-D-aspartate (NMDA) antagonists: Implications for the study and pharmacotherapy of anxiety and schizophrenia
30. Nitric oxide synthase inhibitors do not substitute in rats trained to discriminate phencyclidine from saline
31. The discriminative stimulus effects of N-methyl-D-aspartate antagonists in phencyclidine-trained rats
32. The behavioral pharmacology of NMDA receptor antagonists
33. Minocycline: Possible vestibular side-effects
34. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
35. A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window