Signal transduction targets in invasion

Clinical and Experimental Metastasis

Volumn 19, Issue 3, 2002, Pages 265-273

  Alessandro, Riccardo ^a   Kohn, Elise C ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Integrins; Invasion; Motility; Pathways; Signal transduction; Tyrosine kinase

Indexed keywords

GROWTH FACTOR; INTEGRIN; PROTEIN TYROSINE KINASE;

AUTOCRINE EFFECT; CANCER INVASION; CARCINOGENESIS; CELL INTERACTION; HUMAN; HUMAN CELL; MODEL; PARACRINE SIGNALING; PHENOTYPE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL COMMUNICATION; CELL MOVEMENT; HUMANS; INTEGRINS; MODELS, BIOLOGICAL; NEOPLASM INVASIVENESS; PHENOTYPE; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 0036112509     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015547804511     Document Type: Review

References (80)

1. Molecular signaling mechanisms of cell migration and invasion
2. Induction and regulation of epithelial-mesenchymal transitions
3. Molecular insights into cancer invasion: Strategies for prevention and intervention
4. The microenvironment of the tumor-host invasion field
5. The hallmarks of cancer
6. Structure and biological activity of the extracellular matrix
7. Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo
8. Role of mesenchymal-epithelial interactions in normal and abnormal development of the mammary gland and prostate
9. Growth and metastasis of human breast carcinomas with Matrigel in athymic mice
10. Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice
11. Induction of hepatocyte growth factor in fibroblasts by tumor-derived factors affects invasive growth of tumor cells: In vitro analysis of tumor-stromal interactions
12. Transforming growth factors: Isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction
13. Regulation of autocrine motility factor receptor expression in tumor cell locomotion and metastasis
14. Tumor invasion: Role of growth factor-induced cell motility
15. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
16. Endothelium-derived factors as paracrine mediators of prostate cancer progression
17. The role of alpha v integrins during angiogenesis
18. Regulation of cell motility by mitogen-activated protein kinase
19. Role of transactivation of the EGF receptro in signalling by G-protien-coupled receptors
20. Molecular analysis of signal transduction by growth factors
21. Mechanism of action of anti-HER2 monoclonal antibodies
22. Regulation of the Ras signalling network
23. The signaling pathway coupling epidermal growth factor receptors to activation of p21ras
24. Organization and regulation of mitogen-activated protein kinase signaling pathways
25. Tyrosine protein kinase activity of the EGF receptor is required to induce activation of receptor-operated calcium channels
26. Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF receptor after EGF stimulation
27. The EGF receptor as central transducer of heterologous signalling systems
28. Shaping up for shipping out: PLCgamma signaling of morphology changes in EGF-stimulated fibroblast migration
29. Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferatio
30. Epidermal growth factor receptor-mediated cell motility: Phospholipase C activity is required, but mitogen-activated protein kinase activity is not sufficient for induced cell movement
31. Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly
32. The role of calcium in the regulation of invasion and angiogenesis
33. Endothelial cell spreading on type IV collagen and spreading induced FAK phosphorylation is regulated by calcium influx
34. Regulation of the Rho-A pathway in human endothelial cell spreading on type IV collagen: Role of calcium influx
35. Cell migration: A physically integrated molecular process
36. Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway
37. Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling
38. Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: Involvement in the interaction with phospholipase C-gamma
39. Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
40. Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
41. A point mutation in the MET oncogene abrogates metastasis without affecting transformation
42. Hepatocyte growth factor promotes migration of human hepatocellular carcinoma via phosphatidylinositol 3-kinase
43. Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3′ kinase
44. Involvement of phosphatidylinositide 3′-kinase and Rac in platelet-derived growth factor-induced actin reorganization and chemotaxis
45. Regulation of the cytoskeleton by Rho-family GTPases: Implications for tumour cell invasion
46. PI 3-kinases and Src kinases regulate spreading and migration of cultured VSMCs
47. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
48. Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase
49. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
50. Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
51. Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells
52. Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex
53. Phosphoinositide 3-kinase signalling pathways
54. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
55. Linking molecular therapeutics to molecular diagnostics: Inhibition of the FRAP/RAFT/TOR component of the phosphatidylinositol 3 kinase pathway preferentially blocks PTEN mutant cells in vitro and in vivo
56. AKT plays a central role in tumorigenesis
57. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
58. Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium
59. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
60. Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production
61. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells
62. Anoikis
63. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
64. Extracellular matrix regulates apoptosis in mammary epithelium through a control on insulin signaling
65. Control of adhesion-dependent cell survival by focal adhesion kinase
66. Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase
67. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation
68. Integrin-mediated survival signals regulate the apoptotic localization
69. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
70. Molecular profiling of human cancer
71. Proteomics: New perspectives, new biomedical opportunities
72. Comprehensive genome sequence analysis of a breast cancer amplicon
73. Laser capture microdissection
74. Clinical proteomics: Personalized molecular medicine
75. The new millennium: Applying novel technology to the study of the cancer cell in situ
76. Allelic loss on chromosome arm 8p: Analysis of low malignant potential and invasive epithelial ovarian tumors
77. Loss of annexin I correlates with early onset of tumorigenesis in esophageal and prostate carcinoma
78. Proteomic analysis and identification of new biomarkers and therapeutic targets for invasive ovarian cancer
79. Direct interaction of the Rho GDP dissociation inhibitor with Ezrin/Radixin/Moesin initiates the activation of the Rho small G protein
80. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front