Insights into the role of immune activation in HIV neuropathogenesis

Journal of NeuroVirology

Volumn 8, Issue 2, 2002, Pages 69-75

  Gartner, Suzanne ^a   Liu, Yiling ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Brain; Dementia; HIV; Microglia; Monocyte

Indexed keywords

CELL INVASION; CENTRAL NERVOUS SYSTEM DISEASE; CONTROLLED STUDY; DEMENTIA; DISEASE ASSOCIATION; DISEASE MODEL; HOST CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; INFLAMMATION; LEUKOCYTE ACTIVATION; MONOCYTE; NEUROPATHOLOGY; PRIORITY JOURNAL; REVIEW;

AIDS DEMENTIA COMPLEX; BRAIN; HUMANS; MICROGLIA; MONOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0036096739     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280290049525     Document Type: Review

References (94)

1. Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage
2. Impact of highly active anti-retroviral therapy (HAART) on cytokine production and monocyte subsets in HIV-infected patients
3. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: Identification by the combination of in situ polymerase chain reaction and immunohistochemistry
4. Correlates of SIV encephalitis in rhesus monkeys
5. Turnover of rat brain perivascular cells
6. Human immunodeficiency virus and the brain: Investigation of virus load and neuropathologic changes in pre-AIDS subjects
7. Isolated human astrocytes are not susceptible to infection by M- and T-tropic HIV-1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4
8. Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia
9. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis
10. AIDS dementia complex and HIV-1 brain infection: Clinical-virological correlations
11. Neurologic complications in acquired immunodeficiency syndrome (AIDS)
12. Brain pathology induced by infection with the human immunodeficiency virus
13. Highly productive infection with pseudotyped human immunodeficiency virus type 1 (HIV-1) indicates no intracellular restrictions to HIV-1 replication in primary human astrocytes
14. The treatable dementia of Sjögren's syndrome
15. Cerebral metabolite abnormalities correlate with clinical severity of HIV-1 cognitive motor complex
16. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
17. Human immunodeficiency virus can productively infect cultured human glial cells
18. Isolation frequency of human immunodeficiency virus from cerebrospinal fluid and blood of patients with varying severity of HIV infection
19. Infection of brain-derived cells with the human immunodeficiency virus
20. Human immunodeficiency virus type 1 is present in the cerebrospinal fluid of a majority of infected individuals
21. Human immunodeficiency virus infection of the brain. II. Detection of intrathecally synthesized antibodies by enzyme linked immunosorbent assay and imprint immunofixation
22. HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy
23. Early viral brain invasion in iatrogenic human immunodeficiency virus infection
24. Persistent productive infection of human glial cells by human immunodeficiency virus (HIV) and by infectious molecular clones of HIV
25. Antibody-mediated clearance of viruses from the mammalian central nervous system
26. Redistribution of HIV outside the lymphoid system with onset of AIDS
27. The role of T-cell-mediated mechanisms in virus infections of the nervous system
28. Progressive encephalopathy in children with acquired immune deficiency syndrome
29. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia
30. Vertical human immunodeficiency virus-1 infection. Involvement of the central nervous system and treatment
31. Selective depletion of CD14+ CD16+ monocytes by glucocorticoid therapy
32. HIV infection and dementia
33. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy
34. Accumulation of beta-amyloid precursor protein in HIV encephalitis: Relationship with neuropsychological abnormalities
35. Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia
36. Clinical-neuropathologic correlation in HIV-associated dementia
37. Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env and nef mRNAs despite efficient expression of tat and rev
38. Human immunodeficiency virus (HIV) distribution in HIV encephalitis: Study of 19 cases with combined use of in situ hybridization and immunocytochemistry
39. Neuropathology of AIDS
40. Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy
41. Early brain changes in HIV infection: Neuropathological study of 11 HIV seropositive, non-AIDS cases
42. Neuropathology of early HIV-1 infection
43. The role of antibody in recovery from alphavirus encephalitis
44. CCR3 and CCR5 are coreceptors for HIV-1 infection of microglia
45. Perivascular microglia are bone marrow derived and present antigen in vivo
46. Bone marrow-derived elements in the central nervous system: An immunohistochemical and ultrastructural survey of rat chimeras
47. Simian immunodeficiency virus infection of macaques: End-stage disease is characterized by widespread distribution of proviral DNA in tissues
48. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome
49. Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system
50. Early SIV encephalopathy
51. Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection: Report of a working group of the American Academy of Neurology AIDS Task Force
52. Detection of a vigorous HIV-1-specific cytotoxic T lymphocyte response in cerebrospinal fluid from infected persons with AIDS dementia complex
53. Quantitation of human immunodeficiency virus in brains of demented and nondemented patients with acquired immunodeficiency syndrome
54. Pathways to neuronal injury and apoptosis in HIV-associated dementia
55. Primary Sjögren's syndrome with subcortical dementia
56. Progressive diffuse leukoencephalopathy in patients with acquired immune deficiency syndrome (AIDS)
57. The effects of human immunodeficiency virus in the central nervous system
58. HIV-1-associated central nervous system dysfunction
59. HIV-related metabolic abnormalities in the brain: Depiction with proton MR-spectroscopy with short echo times
60. Human immunodeficiency virus type 1 DNA and RNA load in brains of demented and nondemented patients with acquired immunodeficiency syndrome
61. Yellow fever virus encephalitis: Properties of the brain-associated T-cell response during virus clearance in normal and gamma interferon-deficient mice and requirements for CD4+ T lymphocytes
62. Diminished rev-mediated stimulation of human immunodeficiency virus type 1 is a hallmark of human astrocytes
63. Dendritic injury is a pathological substrate for human immunodeficiency virus-related cognitive disorders
64. The AIDS dementia complex: I. Clinical features
65. Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a block in rev function
66. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acid and tumor necrosis factor-alpha RNA in the central nervous system
67. High levels of unintegrated HIV-1 DNA in brain tissue of AIDS dementia patients
68. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis
69. Evidence of apoptotic cell death in HIV encephalitis
70. Unique monocyte subset in patients with AIDS dementia
71. Increased frequency of the tumor necrosis factor-alpha-308 A allele in adults with human immunodeficiency virus dementia
72. Abundant expression of HIV nef and rev proteins in brain astrocytes in vivo is associated with dementia
73. Early penetration of the blood-brain-barrier by HIV
74. Intra-blood-brain-barrier synthesis of HTLV-III-specific IgG in patients with neurologic symptoms associated with AIDS or AIDS-related complex
75. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in post-mortem pediatric central nervous tissues
76. A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells
77. Pathology of HIV-1 infection of the central nervous system. A review
78. Multinucleated giant cells and HTLV-III in AIDS encephalopathy
79. HTLV-III infection in brains of children and adults with AIDS encephalopathy
80. Apoptosis induced by HIV-1 infection of the central nervous system
81. Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia
82. Immunohistochemical changes and PCR detection of HIV provirus DNA in brains of asymptomatic HIV-positive patients
83. Neurological complications of acquired immune deficiency syndrome: Analysis of 50 patients
84. Localization of HIV-1 in human brain using polymerase chain reaction In situ hybridization and immunocytochemistry
85. HIV-1 infection of subcortical astrocytes in the pediatric nervous system
86. Intrathecal synthesis of anti-HIV IgG: Correlation with increasing duration of HIV-1 infection
87. AIDS encephalopathy and tropism of HIV for brain monocytes/macrophages and microglial cells
88. Basal ganglia metabolite abnormalities in minor motor disorders associated with human immunodeficiency virus type 1
89. Specific tropism of HIV-1 for microglial cells in primary human brain cultures
90. Neuronal damage in the cerebral cortex of AIDS brains: A morphometric study
91. Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome
92. Damage and repair of DNA in HIV encephalitis
93. Perivascular macrophages are the primary cell type productively infected by simian immunodeficiency virus in the brains of macaques: Implications for the neuropathogenesis of AIDS
94. The HIV-1 associated dementia complex: A metabolic encephalopathy fueled by viral replication in mononuclear phagocytes