Diminished Rev-mediated stimulation of human immunodeficiency virus type 1 protein synthesis is a hallmark of human astrocytes

Journal of Virology

Volumn 73, Issue 10, 1999, Pages 8279-8289

  Ludwig, Eva ^a   Ceccherini Silberstein, Francesca ^a   Van Empel, Jutta ^a   Erfle, Volker ^a   Neumann, Markus ^a   Brack Werner, Ruth ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

REV PROTEIN; VIRUS PROTEIN;

ARTICLE; ASTROCYTE; ASTROCYTOMA; CONTROLLED STUDY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; TARGET CELL; TRANSACTIVATION; TRANSCRIPTION REGULATION;

EID: 0032862975     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.10.8279-8289.1999     Document Type: Article

References (67)

1. Aloisi, F., G. Borsellino, P. Samoggia, U. Testa, C. Chelucci, G. Russo, C. Peschle, and G. Levi. 1992. Astrocyte cultures from human embryonic brain: characterization and modulation of surface molecules by inflammatory cytokines. J. Neurosci. Res. 32:494-506.
2. Atwood, W. J., J. R. Berger, R. Kaderman, C. S. Tornatore, and E. O. Major. 1993. Human immunodeficiency virus type 1 infection of the brain. Clin. Microbiol. Rev. 6:339-366.
3. Bagasra, O., E. Lavi, L. Bobroski, K. Khalili, J. P. Pestaner, R. Tawadros, and R. J. Pomerantz. 1996. Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: identification by the combination of in situ polymerase chain reaction and immunohistochemistry. AIDS 10:573-585.
4. Baldwin, T. J., M. S. Fazeli, P. Doherty, and F. S. Walsh. 1996. Elucidation of the molecular actions of NCAM and structurally related cell adhesion molecules. J. Cell. Biochem. 61:502-513.
5. Bigner, D. D., S. H. Bigner, J. Ponten, B. Westermark, M. S. Mahaley, E. Ruoslahti, H. Herschman, L. F. Eng, and C. J. Wikstrand. 1981. Heterogeneity of genotypic and phenotypic characteristics of fifteen permanent cell lines derived from human gliomas. J. Neuropathol. Exp. Neurol. 40:201-229.
6. Bogerd, H. P., A. Echarri, T. M. Ross, and B. R. Cullen. 1998. Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1. J. Virol. 72:8627-8635.
7. Brack-Werner, R. 1999. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. AIDS 13:1-22.
8. Brack-Werner, R., A. Kleinschmidt, A. Ludvigsen, W. Mellert, M. Neumann, R. Herrmann, M. C. Khim, A. Burny, N. Muller-Lantzsch, D. Stavrou, et al. 1992. Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. AIDS 6:273-285.
9. Ceccherini Silberstein, F. Unpublished observations.
10. Cullen, B. R. 1998. Posttranscriptional regulation by the HIV-1 Rev protein. Semin. Virol. 8:327-334.
11. D'Agostino, D. M.,V. Ciminale, G. N.Pavlakis, and L.Chieco-Bianchi. 1995. Intracellular trafficking of the human immunodeficiency virus type 1 Rev protein: involvement of continued rRNA synthesis in nuclear retention. AIDS Res. Hum. Retroviruses 11:1063-1071.
12. de Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
13. Dundr, M., G. H. Leno, M. L. Hammarskjold, D. Rekosh, C. Helga-Maria, and M. O. Olson. 1995. The roles of nucleolar structure and function in the subcellular location of the HIV-1 Rev protein. J. Cell Sci. 108:2811-2823.
14. Eddleston, M., and L. Mucke. 1993. Molecular profile of reactive astrocytes: implications for their role in neurologic disease. Neuroscience 54:15-36.
15. Emerman, M., and M. H. Malim. 1998. HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science 280:1880-1884.
16. Felber, B. K., C. M. Drysdale, and G. N. Pavlakis. 1990. Feedback regulation of human immunodeficiency virus type 1 expression by the Rev protein. J. Virol. 64:3734-3741.
17. Felber, B. K., M. Hadzopoulou-Cladaras, C. Cladaras, T. Copeland, and G. N. Pavlakis. 1989. Rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNA. Proc. Natl. Acad. Sci. USA 86:1495-1499.
18. Frankel, A. D., and J. A. Young. 1998. HIV-1: fifteen proteins and an RNA. Annu. Rev. Biochem. 67:1-25.
19. Frech, K., J. Danescu-Mayer, and T. Werner. 1997. A novel method to develop highly specific models for regulatory units detects a new LTR in GenBank which contains a functional promoter. J. Mol. Biol. 270:674-687.
20. Gorry, P. R., J. L-Howard, M. J. Churchill, J. L. Anderson, A. Cunningham, D. Adrian, D. A. McPhee, and D. F. Purcell. 1999. Diminished production of human immunodeficiency virus type 1 in astrocytes results from inefficient translation of gag, env, and nef mRNAs despite efficient expression of Tat and Rev. J. Virol. 73:352-361.
21. Hope, T. J., X. J. Huang, D. McDonald, and T. G. Parslow. 1990. Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif. Proc. Natl. Acad. Sci. USA 87:7787-7791.
22. Kubota, S., L. Duan, R A. Furuta, M. Hatanaka, and R J. Pomerantz. 1996. Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein. J. Virol. 70:1282-1287. (Authors' correction, 72:3505-3506, 1998.)
23. Kubota, S., R Furuta, M. Maki, and M. Hatanaka. 1992. Inhibition of human immunodeficiency virus type 1 Rev function by a Rev mutant which interferes with nuclear/nucleolar localization of Rev. J. Virol. 66:2510-2513.
24. Lee, S., M. Neumann, R. Stearman, R. Stauber, A. Pause, G. N. Pavlakis, and R. D. Klausner. 1999. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol Cell. Biol. 19:1486-1497.
25. Ludvigsen, A., T. Werner, W. Gimbel, V. Erfle, and R. Brack-Werner. 1996. Down-modulation of HIV-1 LTR activity by an extra-LTR nef gene fragment. Virology 216:245-251.
26. Ludwig, E. Unpublished observations.
27. Malim, M. H., J. Hauber, R. Fenrick, and B. R Cullen. 1988. Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genes. Nature 335:181-183.
28. Mellert, W., A. Kleinschmidt, J. Schmidt, H. Festl, S. Emler, W. K. Roth, and V. Erfle. 1990. Infection of human fibroblasts and osteoblast-like cells with HIV-1. AIDS 4:527-535.
29. Mermer, B., B. K. Felber, M. Campbell, and G. N. Pavlakis. 1990. Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells. Nucleic Acids Res. 18:2037-2044.
30. Meyer, B. E, and M. H. Malim. 1994. The HIV-1 Rev transctivator shuttles between the nucleus and the cytoplasm. Genes Dev. 8:1538-1547.
31. Moreno, T. N., E. A. Fortunato, K. Hsia, S. A. Spector, and D. H. Spector. 1997. A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells. J. Virol. 71:3693-3701.
32. Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
33. Neumann, G., M. R. Castrucci, and V. Kawaoka. 1997. Nuclear import and export of influenza virus nucleoprotein. J. Virol. 71:9690-9700.
34. Neumann, M. Unpublished observations.
35. Neumann, M., B. K. Felber, A. Kleinschmidt, B. Froese, V. Erfle, G. N. Pavlakis, and R. Brack-Werner. 1995. Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function. J. Virol. 69:2159-2167.
36. Niikura, M., G. Dornadula, H. Zhang, M. Mukhtar, D. Lingxun, K. Khalili, O. Bagasra, and R. J. Pomerantz. 1996. Mechanisms of transcriptional transactivation and restriction of human immunodeficiency virus type I replication in an astrocytic glial cell. Oncogene 13:313-322.
37. Nuovo, G. J., F. Gallery, P. MacConnell, and A. Braun. 1994. In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-alpha RNA in the central nervous system. Am. J. Pathol. 144:659-666.
38. Pavlakis, G. N. 1997. The molecular biology of human immunodeficiency virus type 1, p. 45-74. In T. V. DeVita, S. Hellmann, and A. S. Rosenberg (ed.), AIDS: biology, diagnosis, treatment and prevention, vol. 4. Lippincott-Raven Publishers, Philadelphia, Pa.
39. Ponten, J., and E. H. Macintyre. 1968. Long term culture of normal and neoplastic human glia. Acta Pathol. Microbiol. Scand. 74:465-486.
40. Raff, M. C. 1989. Glial cell diversification in the rat optic nerve. Science 243:1450-1455.
41. Ranki, A., M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Raininko, H. Haapasalo, and K. Krohn. 1995. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 9:1001-1008.
42. Richard, N., S. Iacampo, and A. Cochrane. 1994. HIV-1 Rev is capable of shuttling between the nucleus and cytoplasm. Virology 204:123-131.
43. Ridet, J. L., S. K. Malhotra, A. Privat, and F. H. Gage. 1997. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20:570-577. (Erratum, 21:80, 1998.)
44. Rutka, J. T., M. Murakami, P. B. Dirks, S. L. Hubbard, L. E. Becker, K. Fukuyama, S. Jung, A. Tsugu, and K. Matsuzawa. 1997. Role of glial filaments in cells and tumors of glial origin: a review. J. Neurosurg. 87:420-430.
45. Saito, Y., L. R Sharer, L. G. Epstein, J. Michaels, M. Mintz, M. Louder, K. Golding, T. A. Cvetkovich, and B. M. Blumberg. 1994. Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous tissues. Neurology 44:474-481.
46. Schäfer, B. W., and C. W. Heizmann. 1996. The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem. Sci. 21:134-140.
47. Schwartz, S., B. K. Felber, D. M. Benko, E. M. Fenyo, and G. N. Pavlakis. 1990. Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1. J. Virol. 64:2519-2529.
48. Shahabuddin, M., G. Bentsman, B. Volsky, I. Rodriguez, and D. J. Volsky. 1996. A mechanism of restricted human immunodeficiency virus type 1 expression in human glial cells. J. Virol. 70:7992-8002.
49. Shukla, R. R., P. L. Kimmel, and A. Kumar. 1994. Human immunodeficiency virus type 1 Rev-responsive element RNA binds to host cell-specific proteins J. Virol. 68:2224-2229.
50. Shukla, R. R., S. M. Marques, P. L. Kimmel, and A. Kumar. 1996. Human chromosome 6- and 11-encoded factors support human immunodeficiency virus type 1 Rev function in A9 cells. J. Virol. 70:9064-9068.
51. Stauber, R., G. A. Gaitanaris, and G. N. Pavlakis. 1995. Analysis of trafficking of Rev and transdominant Rev proteins in living cells using green fluorescent protein fusions: transdominant Rev blocks the export of Rev from the nucleus to the cytoplasm. Virology 213:439-449.
52. Stauber, R. H., E. Afonina, S. Gulnik, J. Erickson, and G. N. Pavlakis. 1998. Analysis of intracellular trafficking and interactions of cytoplasmic HIV-1 Rev mutants in living cells. Virology 251:38-48.
53. Stauber, R. H., K. Horie, P. Carney, E. A. Hudson, N. I. Tarasova, G. A. Gaitanaris, and G. N. Pavlakis. 1998. Development and applications of enhanced green fluorescent protein mutants. BioTechniques 24:462-466, 468-471.
54. Stauber, R. H., and G. N, Pavlakis. 1998. Intracellular trafficking and inter-actions of the HIV-1 Tat protein. Virology 252:126-136.
55. Stavrou, D., E. Keiditsch, F. Schmidberger, K. Bise, I. Funke, W. Eisenmenger, R. Kurrle, B. Martin, and U. Stocker. 1987. Monoclonal antibodies against human astrocytomas and their reactivity pattern. J. Neurol. Sci. 80:205-220.
56. Tabernero, C., A. S. Zolotukhin, A. Valentin, G. N. Pavlakis, and B. K. Felber. 1996. The posttranscriptional control element of the simian retrovirus type 1 forms an extensive RNA secondary structure necessary for its function. J. Virol. 70:5998-6011.
57. Takahashi, K., S. L. Wesselingh, D. E. Griffin, J. C. McArthur. R. T. Johnson, and J. D. Glass. 1996. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunocytochemistry. Ann. Neurol. 39:705-711.
58. Tornatore, C., R. Chandra, J. R. Berger, and E. O. Major. 1994. HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology 44:481-487.
59. Tornatore, C., K. Meyers, W. Atwood, K. Conant, and E. Major. 1994. Temporal patterns of human immunodeficiency virus type 1 transcripts in human fetal astrocytes. J. Virol. 68:93-102.
60. Trono, D., and D. Baltimore. 1990. A human cell factor is essential for HIV-1 Rev action. EMBO J. 9:4155-4160.
61. Wang, P., P. Palese, and R. E. O'Neill. 1997. The NPI-1/NPI-3 (karyopherin α) binding site on the influenza A virus nucleoprotein NP is a nonconventional nuclear localization signal. J. Virol. 71:1850-1856.
62. Wei, P., M. E. Garber, S. M. Fang, W. H. Fischer, and K. A. Jones. 1998. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 92:451-462.
63. Westermark, B., J. Ponten, and R. Hugosson. 1973. Determinants for the establishment of permanent tissue culture lines from human gliomas. Acta Pathol. Microbiol. Scand. Sect. A 81:791-805.
64. Wilkin, G. P., D. R. Marriott, and A. J. Cholewinski. 1990, Astrocyte heterogeneity. Trends Neurosci. 13:43-46.
65. Winslow, B. J., and D. Trono. 1993. The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent. J. Virol. 67:2349-2354.
66. Wolff, B., J. J. Sanglier, and Y. Wang. 1997. Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA, Chem. Biol. 4:139-147.
67. Wu, Y., L. Duan, M. Zhu, B. Hu, S. Kubota, O. Bagasra, and R. J. Pomerantz. 1996. Binding of intracellular anti-Rev single chain variable fragments to different epitopes of human immunodeficiency virus type 1 Rev: variations in viral inhibition. J. Virol. 70:3290-3297. (Authors' correction, 72:3505-3506, 1998.)