Impact of highly active anti-retroviral therapy (HAART) on cytokine production and monocyte subsets in HIV-infected patients

Clinical and Experimental Immunology

Volumn 120, Issue 1, 2000, Pages 107-112

  Amirayan Chevillard, N ^a   Tissot Dupont, H ^b   Capo, C ^a   Brunet, C ^c   Dignat George, F ^c   Obadia, Y ^d   Gallais, H ^b   Mege, J L ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b service de maladies infectieuses   (France)

^c HÔPITAL DE LA CONCEPTION   (France)

^d OBSERVATOIRE RÉGIONAL DE LA SANTÉ PROVENCE ALPES CÔTE D AZUR   (France)

Author keywords

Anti retroviral therapy; Cytokines; HIV; Monocyte subsets

Indexed keywords

ANTIRETROVIRUS AGENT; DIDANOSINE; INDINAVIR; LAMIVUDINE; NELFINAVIR; NEVIRAPINE; RITONAVIR; SAQUINAVIR; ZALCITABINE; ZIDOVUDINE;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CYTOKINE RELEASE; DRUG EFFECT; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; QUALITY OF LIFE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

EID: 0034025106     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01201.x     Document Type: Article

References (31)

1. Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998; 338:853-60.
2. Cameron DW, Heath-Chiozzi M, Danner S et al. Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease. Lancet 1998; 351:543-9.
3. Collier AC, Coombs RW, Schoenfeld DA et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. N Engl J Med 1996; 334:1011-8.
4. Nielsen SD, Ersboll AK, Mathiesen L, Nielsen JO, Hansen JES. Highly active antiretroviral therapy normalizes the function of progenitor cells in human immunodeficiency virus-infected patients. J Infect Dis 1998; 178:1299-305.
5. Pakker NG, Notermans DW, de Boer RJ et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nature Med 1998; 4:208-14.
6. + T cell homeostasis and function in advanced HIV disease. Science 1997; 277:112-6.
7. Li TS, Tubiana R, Katlama C, Calvez V, Mohand A, Autran B. Long-lasting recovery in CD4 T cell function and viral load reduction after highly active antiretroviral therapy in advanced HIV-1 disease. Lancet 1998; 351:1682-6.
8. David D, Bani L, Moreau JL et al. Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy. Proc Natl Acad Sci USA 1998; 95:11348-53.
9. Gendelman HE, Orenstein JM, Baca LM, Weiser B, Burger H, Kalter DC, Meltzer MS. The macrophage in the persistence and pathogenesis of HIV infection. AIDS 1989; 3:475-95.
10. McElrath MJ, Pruett JE, Cohn ZA. Mononuclear phagocytes of blood and bone marrow: comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections. Proc Natl Acad Sci USA 1989; 86:675-9.
11. Harrison TS, Kornfeld H, Levitz SM. The effect of infection with human immunodeficiency virus on the anticryplococcal activity of lymphocytes and monocytes. J Infect Dis 1995; 172:665-71.
12. Meyaard L, Schuitemaker H, Miedema F. T-cell dysfunction in HIV infection: anergy due to defective antigen-presenting cell function. Immunol Today 1993; 14:161-4.
13. Yoo J, Chen H, Kraus T, Hirsch D, Polyak S, George I, Sperber K. Altered cytokine production and accessory cell function after HIV-1 infection. J Immunol 1996; 157:1313-20.
14. Roux-Lombard P, Modoux C, Cruchaud A, Dayer JM. Purified blood monocytes from HIV-1-infected patients produce high levels of TNF-α and IL-1. Clin Immunol Immunopathol 1989; 50:374-84.
15. Lathey JL, Kanangat S, Rouse BT, Agosti JM, Spector SA. Dysregulation of cytokine expression in monocytes from HIV-positive individuals. J Leuk Biol 1994; 56:347-52.
16. Matsuyama T, Hamamoto Y, Soma GI, Mizuno D, Yamamoto N, Kobayashi N. Cytocidal effect of tumor necrosis factor on cells chronically infected with human immunodeficiency virus (HIV): enhancement of HIV replication. J Virol 1989; 63:2504-9.
17. Poli G, Bressler P, Kinter A et al. Inlerleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor α by transcriptional and post-transcriptional mechanisms. J Exp Med 1990; 172:151-8.
18. high: a cytokine-producing monocyte subset which expands during human immunodeficiency virus infection. Eur J Immunol 1995; 25:3418-24.
19. Perno CF, Newcomb FM, Davis DA, Aquaro S, Humphrey RW, Calio R, Yarchoan R. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J Infect Dis 1998; 178:413-22.
20. Rusconi S, Merrill DP, Hirsch MS. Inhibition of human immunodeficiency virus type 1 replication in cytokine-stimulated monocytes/macrophages by combination therapy. J Infect Dis 1994; 170:1361-6.
21. Al-Harthi L, Roebuck KA, Kessler H, Landay A. Inhibition of cytokine-driven human deficiency virus type 1 replication by protease inhibitor. J Infect Dis 1997; 176:1175-9.
22. Carrieri MP, Moatti JP, Vlahov D, Obadia Y, Reynaud-Maurupt C, Chesney M, the MANIF 2000 Study Group. Access to antiretroviral treatment among French HIV infected injection drug users: the influence of continued drug use. Epidemiol Community Health 1999; 53:4-8.
23. Sanguedolce MV, Capo C, Bongrand P, Mege JL. Zymosan-stimulated tumor necrosis factor-α production by human monocytes. Down-modulation by phorbol ester. J Immunol 1992; 148:2229-36.
24. Bikoue A, George F, Poncelet P, Mutin M, Janossy G, Sampol J. Quantitative analysis of leukocyte membrane antigen expression: normal adult values. Cytometry 1996; 26:137-47.
25. Wright SC, Jewett A, Nitsuyasu R, Bonavida B. Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients. J Immunol 1988; 141:99-104.
26. Breen EC, Rezai AR, Nakajima K, Beall GN, Mitsuyasu RT, Hirano T, Kishimoto T, Martinez-Maza O. Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 1990; 144:480-4.
27. Chougnet C, Wynn TA, Clerici M et al. Molecular analysis of decreased IL-12 production in individuals infected with the human immunodeficiency virus. J Infect Dis 1996; 174:46-53.
28. Shearer GM. HIV-induced immunopathogenesis. Immunity 1998; 9:587-93.
29. Chougnet C, Fowke KR, Mueller BU et al. Protease inhibitor and triple-drug therapy: cellular immune parameters are not restored in pediatric AIDS patients after 6 months of treatment. AIDS 1998; 12:2397-406.
30. Clerici M, Landay AL, Kessler HA, Phair JP, Venzon DJ, Hendrix CW, Lucey DR, Shearer GM. Reconstitution of long-term T helper cell function after zidovudine therapy in human immunodeficiency virus-infected patients. J Infect Dis 1992; 166:723-30.
31. Kelleher AD, Sewell WA, Cooper DA. Effect of protease therapy on cytokine secretion by peripheral blood mononuclear cells (PBMC) from HIV-infected subjects. Clin Exp Immunol 1999; 115:147-52.