Damage and repair of DNA in HIV encephalitis

Journal of Neuropathology and Experimental Neurology

Volumn 59, Issue 11, 2000, Pages 955-965

  Wiley, Clayton A ^a,e   Achim, Cristian L ^a   Hammond, Robert ^b   Love, Seth ^c   Masliah, Eliezer ^d   Radhakrishnan, Lakshmi ^a   Sanders, Virginia ^d   Wang, Guoji ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c FRENCHAY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

Author keywords

AIDS; Amyloid precursor protein; DNA damage; DNA repair; Encephalitis HIV; Poly (ADP ribose) polymerase (PARP)

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DNA; DNA POLYMERASE; DNA REPAIR ENZYME KU80; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; AUTOPSY; BASAL GANGLION; BRAIN CELL; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPLASM; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GLIA CELL; GRAY MATTER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MACROPHAGE; NICK END LABELING; OLIGODENDROGLIA; OPPORTUNISTIC INFECTION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS ENCEPHALITIS;

EID: 0033762924     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/59.11.955     Document Type: Article

References (52)

1. Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus type-1 (HIV-1) infection
2. Clinical confirmation of the American Academy of Neurology algorithm for HIV-1-associated cognitive/motor disorder. The Dana Consortium on Therapy for HIV Dementia and Related Cognitive Disorders
3. HIV-1 associated dementia: Clinical features and pathogenesis
4. The AIDS dementia complex: II. Neuropathology
5. The AIDS dementia complex: I. Clinical features
6. HIV-associated disease of the nervous system: Review of nomenclature and proposal for neuropathology-based terminology
7. Loss of neurons in the frontal cortex in AIDS brains
8. Neuronal loss in the frontal cortex in HIV infection
9. Neocortical damage during HIV infection
10. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia
11. HIV-1 infection: No evidence of cognitive decline during the asymptomatic stages. The Multicenter AIDS Cohort Study
12. Dementia in AIDS patients: Incidence and risk factors. Multicenter AIDS Cohort Study
13. Neuronal loss in the hippocampus in Huntington's disease: A comparison with HIV infection
14. Neuronal apoptosis in HIV-infection in adults
15. Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy
16. Evidence of apoptotic cell-death in HIV encephalitis
17. Apoptosis induced by HIV-1 infection of the central nervous system
18. Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: Evidence for a role of the envelope
19. Mutant superoxide dismutase-1-linked familial amyotrophic lateral sclerosis: Molecular mechanisms of neuronal death and protection
20. Free radical mechanisms in dementia of Alzheimer type and the potential for antioxidative treatment
21. Oxidative stress, age-related neurodegeneration, and the potential for neurotrophic treatment
22. Oxidative stress and apoptosis in neurodegeneration
23. Oxidative stress in Parkinson's disease and other neurodegenerative disorders
24. Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man
25. Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease
26. Evidence for neuronal apoptosis in pontosubicular neuron necrosis
27. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay
28. Neocortical damage during HIV infection
29. Distribution of brain HIV load in AIDS
30. Confocal microscopy assessment of lymphoid tissues with follicular hyperplasia from patients infected with human immunodeficiency virus type 1
31. HIV mediates a productive infection of the brain
32. Neuronal apoptosis does not correlate with dementia in HIV infection but is related to microglial activation and axonal damage
33. Brain viral burden in HIV-infection
34. At the scene of ischemic brain injury: Is PARP a perp?
35. Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase
36. Nicotinamide as a precursor for NAD+ prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide
37. Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development
38. Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation
39. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
40. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase
41. Poly(ADP-ribose) polymerase is found in both the nucleus and cytoplasm of human CNS neurons
42. Temporal and regional patterns of axonal damage following traumatic brain injury: A beta-amyloid precursor protein immunocytochemical study in rats
43. The diagnosis of diffuse axonal injury: Implications for forensic practice
44. Diffuse axonal injury in infants with nonaccidental craniocerebral trauma: Enhanced detection by beta-amyloid precursor protein immunohistochemical staining
45. The visualization of a new class of traumatically injured axons through the use of a modified method of microwave antigen retrieval
46. Staining of amyloid precursor protein to study axonal damage in mild head injury
47. Axonal damage revealed by accumulation of beta-APP in HIV-positive individuals without AIDS
48. Accumulation of beta-amyloid precursor protein in HIV encephalitis: Relationship with neuropsychological abnormalities
49. Cerebral white matter damage in HIV infection demonstrated using beta-amyloid precursor protein immunoreactivity
50. Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid
51. Redox and activation status of monocytes from human immunodeficiency virus-infected patients: Relationship with viral load
52. Expression of brain-derived neurotrophic factor protein in activated microglia of human immunodeficiency virus type 1 encephalitis