Neurobiology and genetics of borderline personality disorder

Psychiatric Annals

Volumn 32, Issue 6, 2002, Pages 329-336

  New, Antonia S ^a   Siever, Larry J ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; PROLACTIN; SEROTONIN 1B RECEPTOR; SEROTONIN TRANSPORTER; TRYPTOPHAN HYDROXYLASE;

AFFECT; AGGRESSIVENESS; ALLELE; ANTISOCIAL BEHAVIOR; ARSON; ASSAULT; AUTOMUTILATION; BORDERLINE STATE; BRAIN METABOLISM; CLINICAL FEATURE; DESTRUCTION; DISEASE PREDISPOSITION; DNA SEQUENCE; DOMESTIC VIOLENCE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GLUCOSE METABOLISM; HERITABILITY; HUMAN; IMAGING SYSTEM; IMPULSIVENESS; MENTAL INSTABILITY; MOLECULAR GENETICS; MOLECULAR PROBE; NEOCORTEX; NEUROBIOLOGY; NEUROENDOCRINOLOGY; NONHUMAN; PHENOMENOLOGY; PHENOTYPE; POSITRON EMISSION TOMOGRAPHY; PSYCHIATRIC DIAGNOSIS; REVIEW; SEROTONINERGIC SYSTEM; SUICIDE ATTEMPT;

EID: 0036088763     PISSN: 00485713     EISSN: None     Source Type: Journal    
DOI: 10.3928/0048-5713-20020601-07     Document Type: Review

References (83)

1. Kavoussi RJ, Coccaro EF, Klar HM, Bernstein D, Siever LJ. Structured interviews for borderline personality disorder. Am J Psychiatry. 1990;147:1522-1525.
2. Siever LJ, Davis KL. A psychobiologic perspective on the personality disorders. Am J Psychiatry. 1991;148:1647-1658.
3. Koenigsberg HW, Harvey PD, Mitropoulou V, et al. Are the interpersonal and identity disturbances in the borderline personality disorder criteria linked to the traits of affective instability and impulsivity? J Personal Disord. 2001;15:358-370.
4. Sanislow CA, Grilo CM, McGlashan TH. Factor analysis of the DSM-III-R borderline personality disorder criteria in psychiatric inpatients. Am J Psychiatry. 2000;157:1629-1633.
5. Virkkunen M, Eggert M, Rawlings R, Linnoila M. A prospective follow-up study of alcoholic violent offenders and fire setters. Arch Gen Psychiatry. 1996;53:523-529.
6. Dutton DG, Starzomski A, Ryan L. Antecedents of abusive personality and abusive behavior in wife assaulters. Journal of Family Violence. 1996;11:113-132.
7. Goodman M, New AS. Impulsive aggression in borderline personality disorder. Current Psychiatry Reports. 2000;2:56-61.
8. Linnoila M, DeJong J, Virkkunen M. Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry. 1989;46:613-616.
9. Virkkunen M, Rawlings R, Tokola R, et al. CSF biochemistries, glucose metabolism, and diurnal activity rhythms in alcoholic violent offenders, fire setters, and healthy volunteers. Arch Gen Psychiatry. 1994;51:20-27.
10. Lidberg L, Belfrage H, Bertilsson L, Evenden MM, Asberg M. Suicide attempts and impulse control disorder are related to low cerebrospinal fluid 5-HIAA in mentally disordered violent offenders. Acta Psychiatr Scand. 2000;101:395-402.
11. Asberg M. Neurotransmitters and suicidal behavior: the evidence from cerebrospinal fluid studies. Ann NY Acad Sci. 1997;836:158-181.
12. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF. Aggression in human correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1979;1:131-139.
13. Coccaro EF, Siever LJ, Klar HM, et al. Serotonin studies in patients with affective and personality disorders. Arch Gen Psychiatry. 1989;46:587-599.
14. O'Keane V, Maloney E, O'Neil H, O'Connor A, Smith C, Dinan TG. Blunted prolactin response to d-fenfluramine in sociopathy: evidence for subsensitivity of central serotonergic function. Br J Psychiatry. 1992;160:643-646.
15. Coccaro EF, Kavoussi RJ, Hauger RL. Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. Int Clin Psychopharmacol. 1995;10:177-179.
16. Siever LJ, Murphy DL, Slater S, de la Vega E, Lipper S. Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression. Life Sci. 1984;34:1029-1039.
17. Mitchell P, Smythe G. Hormonal responses to fenfluramine in depressed and control subjects. J Affect Disord. 1990;19:43-51.
18. Lopez-Ibor JJ Jr, Saiz-Ruiz J, Iglesias LM. The fenfluramine challenge test in the affective spectrum: a possible marker of endogeneity and severity. Pharmacopsychiatry. 1988;21:9-14.
19. Asnis GM, Eisenberg J, vanPraag HM, et al. The neuroendocrine response to fenfluramine in depressive and normal controls. Biol Psychiatry. 1988;24:117-120.
20. Fava M, Vuolo RD, Wright EC, Nierenberg AA, Alpert JE, Rosenbaum JF. Fenfluramine challenge in unipolar depression with and without anger attacks. Psychiatry Res. 2000;94:9-18.
21. New AS, Trestman RL, Mitropoulou V, et al. Serotonergic function and self-injurious behavior in personality disorder patients. Psychiatry Res. 1997;69:17-26.
22. Coccaro EF, Kavoussi RJ. Fluoxetine and impulsive aggressive behavior in personality-disordered subjects. Arch Gen Psychiatry. 1997;54:1081-1088.
23. Silverman JM, Pinkham L, Horvath TB, et al. Affective and impulsive personality disorder traits in the relatives of patients with borderline personality disorder. Am J Psychiatry. 1991;148:1378-1385.
24. Torgersen S. Genetics of patients with borderline personality disorder. Psychiatr Clin North Am. 2000;23:1-9.
25. Torgersen S. Genetic and nosological aspects of schizotypal and borderline personality disorders. A twin study. Arch Gen Psychiatry. 1984;41:546-554.
26. Bouchard TJ Jr. Genes, environment, and personality. Science. 1994;264(5166):1700-1701.
27. Coccaro EF, Bergman CS, McLean GE. Heritability of irritable impulsiveness: a study of twins reared together and apart. Psychiatry Res. 1993;48:229-242.
28. Bohman M, Cloninger CR, von Knorring A, Sigvardsson S. An adoption study of somatoform disorders, III: crossfostering analysis and genetic relationship to alcoholism and criminality. Arch Gen Psychiatry. 1984;41:872-878.
29. Nielsen DA, Dean M, Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am J Hum Genet. 1992;51:1366-1371.
30. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5-hydroxyindolacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry. 1994;51:34-38.
31. Nielsen DA, Virkkunen M, Lappalainen J, et al. A tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry. 1998;55:593-602.
32. Abbar M, Courtet P, Bellivier F, et al. Suicide attempts and the tryptophan hydroxylase gene. Mol Psychiatry. 2001;6:268-273.
33. Mann JJ, Malone KM, Nielson DA, Goldman D, Erdos J, Gerlenter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am J Psychiatry. 1997;154:1451-1453.
34. Kunugi H, Ishida S, Kato T, et al. No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders of attempted suicide among Japanese patients. Am J Psychiatry. 1999;156:774-776.
35. Geijer T, Frisch A, Persson ML, et al. Search for association between suicide attempt and serotonergic polymorphisms. Psychiatr Genet. 2000;10:19-26.
36. New AS, Gelernter J, Yovell Y, et al. Increases in irritable aggression associated with "LL" genotype at the tryptophan hydroxylase locus. Am J Med Genet. 1998;81:13-17.
37. Manuck SB, Flory JD, Ferrell RE, Dent KM, Mann JJ, Muldoon MF. Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. Biol Psychiatry. 1999;45:603-614.
38. Lesch K, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527-1531.
39. Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH. No association between the serotonin transporter gene regulation region polymorphism and the tridimensional personality questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry. 1997;2:224-226.
40. Gelernter J, Kranzler H, Coccaro EF, Siever LJ, New AS. Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. Am J Psychiatry. 1998;155:1332-1338.
41. Mann JJ, Huang YY, Underwood MD, et al. A serotonin transporter gene promoter polymorphism (HTTLPR) and prefrontal cortical binding in major depression and suicide. Arch Gen Psychiatry. 2000;57:729-738.
42. Russ MJ, Lachman HM, Kasdan T, Saito T, Bajmakovic-Kacila S. Analysis of catechol-O-methyltransferase and 5-hydroxytryptamine transporter polymorphisms in patients at risk for suicide. Psychiatry Res. 2000;93:73-78.
43. Bondy B, Erfurth A, De Jonge S, Kruger M, Meyer H. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Mol Psychiatry. 2000;5:193-195.
44. Bellivier F, Szoke A, Henry C, et al. Possible association between serotonin transporter gene polymorphism and violent suicidal behavior in mood disorders. Biol Psychiatry. 2000;48:319-322.
45. 1B receptor. Science. 1994;265(5180):1875-1878.
46. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost B. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase. Science. 1993;262(5133):578-580.
47. 1D-like pharmacological specificity. Biochem Biophys Res Commun. 1992;184:752-759.
48. Jin H, Oksenberg D, Ashkenazi A, et al. Characterization of the human 5-hydroxytryptamine 1B receptor. J Biol Chem. 1992;267:5735-5738.
49. 1B receptor gene in two populations. Arch Gen Psychiatry. 1998;55:989-994.
50. New AS, Gelernter J, Goodman M, et al. Suicide, impulsive aggression, and HTR1B genotype. Biol Psychiatry. In press.
51. Huang Y, Grailhe R, Arango V, Hen R, Mann JJ. Relationship of pathology to the human serotonin 1B genotype and receptor binding kinetics in postmortem brain tissue. Neuropsychopharmacology. 1999;21:238-246.
52. 2 receptors in suicide victims. Biol Psychiatry. 1994;35:457-463.
53. 1D binding in globus pallidus but not cortex. Mol Psychiatry. 1997;2:314-321.
54. Damasio H, Grabowski T, Frank R, et al. The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science. 1994;264:1102-1105.
55. Weiger WA, Bear DM. An approach to the neurology of aggression. J Psychiatr Res. 1988;22:85-98.
56. Anderson SW, Bechara A, Damasio H, et al. Impairment of social and moral behavior related to early damage in human prefrontal cortex. National Neuroscience. 1999;2:1032-1037.
57. Raine A, Lencz T, Bihrle S, et al. Reduced prefrontal gray volume and autonomic deficits in antisocial personality disorder. Arch Gen Psychiatry. 2000;57:119-127.
58. Spoont MR. Modulatory role of serotonin in the neural information processing: implications for human psychopathology. Psychol Bull. 1992;112:330-350.
59. Raine A, Buchsbaum M, LaCasse L. Brain abnormalities in murderers indicated by positron emission tomography. Biol Psychiatry. 1997;42:495-508.
60. Raine A, Stoddard J, Bihrle S, et al. Prefrontal glucose deficits in murderers lacking psychosocial deprivation. Neuropsychiatry Neuropsychol Behav Neurol. 1998;11:1-7.
61. Goyer PF, Andreason PJ, Semple WE, et al. Positron-emission-tomography and personality disorders. Neuropsychopharmacology. 1994;10:21-28.
62. Mann J, Malone K, Diehl D, et al. Positron emission tomographic imaging of serotonin activation effects on prefrontal cortex in healthy volunteers. J Cereb Blood Flow Metab. 1996;16:418-426.
63. Mann J, Malone KM, Diehl DJ, et al. Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients. Am J Psychiatry. 1996;153:174-182.
64. Meyer JH, Kapur S, Wilson AA, DaSilva J, Houle S, Brown GM. Neuromodulation of frontal and temporal cortex by intravenous d-fenfluramine PET study in humans. Neurosci Lett. 1996;207:25-28.
65. Siever LJ, Buchsbaum M, New AS, et al. d,l-fenfluramine response in impulsive personality disorder assessed with 18F-deoxyglucose positron emission tomography. Neuropsychopharmacology. 1999;20:413-423.
66. Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM. A fenfluramine-activated FDG-PET study of borderline personality disorder. Biol Psychiatry. 2000;47:540-547.
67. Davidson M, Mohs R, Siever LJ. Affective and impulsive personality traits in the relatives of patients with borderline personality disorder. Am J Psychiatry. 1991;148;10:1378-1385.
68. Akiskal HS, Bourgeois ML, Angst J, Post R, Moller H, Hirschfeld R. Re-evaluating the prevalence of and diagnostic composition within the broad clinical spectrum of bipolar disorders. J Affect Disord. 2000;59(suppl 1):S5-S30.
69. Henry C, Mitropoulou V, New AS, Koenigsberg HW, Silverman J, Siever LJ. Affective instability and impulsivity in borderline personality and bipolar II disorders: similarities and differences. J Psychiatr Res. 2001;35:307-312.
70. Janowsky DS, el-Yousef MK, Davis JM. Acetylcholine and depression. Psychosom Med. 1974;36:248-257.
71. Risch SC, Janowsky DS, Gillin JC. Muscarinic supersensitivity of anterior pituitary ACTH and B-endorphin release in major depressive illness. Peptides. 1983;4:789-792.
72. Kellner CH, Post RM, Putnam F, et al. Intravenous procaine as a probe of limbic system activity in psychiatric patients and normal controls. Biol Psychiatry. 1987;22:1107-1126.
73. Steinberg BJ, Trestman R, Mitropoulou V, et al. Depressive response to physostigmine challenge in borderline personality disorder patients. Neuropsychopharmacology. 1997;17:264-273.
74. Gurvits IG, Koenigsberg HW, Siever LJ. Neurotransmitter dysfunction in patients with borderline personality disorder. Psychiatr Clin North Am. 2000;23:27-40.
75. Lane RD, Reiman EM, Ahern GL, Schwartz GE, Davidson RJ. Neuroanatomical correlates of happiness, sadness, and disgust. Am J Psychiatry. 1997;154:926-933.
76. Coccaro EF, Lawrence T, Trestman R, Gabriel S, Klar HM, Siever LJ. Growth hormone responses to intravenous clonidine challenge correlate with behavioral irritability in psychiatric patients and healthy volunteers. Psychiatry Res. 1991;39:129-139.
77. Ketter TA, Andreason PJ, George MS, et al. Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry. 1996;53:59-69.
78. Baxter LR Jr, Schwartz JM, Phelps ME, et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243-250.
79. George MS, Ketter TA, Parekh PI, et al. Blunted left cingulate activation in mood disorder subjects during a response interference task (the Stroop). J Neuropsychiatry Clin Neurosci. 1997;9:55-63.
80. Mayberg HS, Brannan SK, Mahurin RK, et al. Cingulate function in depression: a potential predictor of treatment response. Neuroreport. 1997;8:1057-1061.
81. Blumberg HP, Stern E, Ricketts S, et al. Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. Am J Psychiatry. 1999;156:1986-1988.
82. Blumberg HP, Stern E, Martinez D, et al. Increased anterior cingulate and caudate activity in bipolar mania. Biol Psychiatry. 2000;48:1045-1052.
83. Lane RD, Reiman EM, Axelrod B, Yun LS, Holmes A, Schwartz GE. Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. Journal of Cognitive Neuroscience. 1998;10:525-535.