Reversal of tolerance induced by transplantation of skin expressing the immunodominant T cell epitope of rat type II collagen entitles development of collagen-induced arthritis but not graft rejection

European Journal of Immunology

Volumn 32, Issue 6, 2002, Pages 1773-1783

  Bäcklund, Johan ^a   Treschow, Alexandra ^a   Firan, Mihail ^b   Malmström, Vivianne ^a   Issazadeh Navikas, Shohreh ^a   Ward, E Sally ^b   Holmdahl, Rikard ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autoimmunity; Disease model, animal; Transgenic mouse; Transplantation tolerance

Indexed keywords

COLLAGEN TYPE 2; EPITOPE; IMMUNOLOGICAL ADJUVANT;

ADJUVANT DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTHRITIS; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE COURSE; DISEASE PREDISPOSITION; GRAFT REJECTION; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; REVERSAL REACTION; SKIN TRANSPLANTATION; T LYMPHOCYTE; TRANSGENIC MOUSE;

AGE FACTORS; ANIMALS; ARTHRITIS; COLLAGEN TYPE II; EPITOPES, T-LYMPHOCYTE; GLYCOSYLATION; GRAFT REJECTION; IMMUNE TOLERANCE; IMMUNODOMINANT EPITOPES; LYMPHOCYTES; MALE; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; SKIN TRANSPLANTATION;

EID: 0036086532     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200206)32:6<1773::AID-IMMU1773>3.0.CO;2-Z     Document Type: Article

References (45)

1. Immunisation against heterologous type II collagen induces arthritis in mice
2. B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)
3. Collagen-induced arthritis development requires alpha beta T cells but not gamma delta T cells: Studies with T cell-deficient (TCR mutant) mice
4. Association of the B cell alloantigen DRw4 with rheumatoid arthritis
5. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
6. Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates
7. Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis
8. Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: Self tolerance at the level of determinant selection
9. T cell recognition of carbohydrates on type II collagen
10. Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis
11. Type II collagen in cartilage evokes peptide-specific tolerance and skews the immune response
12. Homologous type II collagen induces chronic and progressive arthritis in mice
13. Experimental autoimmune arthritis in mice. I. Homologous type II collagen is responsible for self-perpetuating chronic polyarthritis
14. Systemic versus cartilage-specific expression of a type II collagen-specific T cell epitope determines the level of tolerance and susceptibility to arthritis
15. T cells that are naturally tolerant to cartilage-derived type II collagen are involved in the development of collagen-induced arthritis
16. Characterization of recombinant type II collagen: Arthritogenicity and tolerogenicity in DBA/1 mice
17. A recurrent Vα17/Vβ10 TCR-expressing T cell clone is involved in the pathogenicity of collagen-induced arthritis in DBA/1 mice
18. The role of clonal anergy in the avoidance of autoimmunity: Inactivation of autocrine growth without loss of effector function
19. Anergic T cells as active regulators of the immune response
20. T cell anergy and peripheral T cell tolerance
21. Successful T cell priming in B cell-deficient mice
22. + T cells or B cells
23. Antigen persistence and time of T cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection
24. T cell regulation of collagen-induced arthritis in mice. I. Isolation of Type II collagen-reactive T cell hybridomas with specific cytotoxic function
25. T cell regulation of collagen-induced arthritis in mice. II. Immuno-modulation of arthritis by cytotoxic T cell hybridomas specific for type II collagen
26. T cell-targeted immunotherapy in murine collagen-induced arthritis
27. Influence of CD4 or CD8 deficiency on collagen-induced arthritis
28. The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice
29. Failure to induce organ-specific autoimmunity by breaking of tolerance: Importance of the microenvironment
30. Maintenance of in vivo tolerance by persistence of antigen
31. Clonal anergy blocks in vivo growth of mature T cells and can be reversed in the absence of antigen
32. The fate of anergic T cells in vivo
33. + T cells persist in vivo following induction of peripheral tolerance
34. Persistence of physiological self antigen is required for the regulation of self tolerance
35. Control of neonatal tolerance to tissue antigens by peripheral T cell trafficking
36. Immunity or tolerance: Opposite outcomes of microchimerism from skin grafts
37. Macrophages, but not dendritic cells, present collagen to T cells
38. Nature of the collagen synthesized by a transplanted chondrosarcoma
39. Analysis of type II collagen-reactive T cells in the mouse. I. Different regulation of autoreactive vs. non-autoreactive anti-type II collagen T cells in the DBA/1 mouse
40. T cells recognize a glycopeptide derived from type II collagen in a model for rheumatoid arthritis
41. Genetic analysis of mouse models for rheumatoid arthritis
42. High antibody response to autologous type II collagen is restricted to H-2q
43. Revisiting tolerance induced by autoantigen in incomplete Freund's adjuvant
44. Detection of autoreactive T cells in H-2(u) mice using peptide-MHC multimers
45. Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis