Upregulation of collagens detected by gene array in a model of flow-induced pulmonary vascular remodeling

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 282, Issue 2 51-2, 2002, Pages

  Medhora, Meetha ^a   Bousamra II, Michael ^c   Zhu, Daling ^a   Somberg, Lewis ^b   Jacobs, Elizabeth R ^a  

^a Cardiovascular Research Center   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c University of Louisville School of Medicine   (United States)

Author keywords

Cardiovascular; High flow; Porcine; Pulmonary arteries; Pulmonary hypertension; Shear; Vasculopathy

Indexed keywords

CELL ADHESION MOLECULE; COMPLEMENTARY DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTERY RESISTANCE; ARTICLE; AUTORADIOGRAPHY; CELL ADHESION; COLLAGEN METABOLISM; CONTROLLED STUDY; DNA MICROARRAY; DNA SEQUENCE; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION; SIGNAL DETECTION; SPECIES DIFFERENTIATION; SWINE; WESTERN BLOTTING;

EID: 0036084720     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00292.2001     Document Type: Article

References (56)

1. Primary pulmonary hypertension: A vascular biology and translational research "work in progress."
2. Responsiveness of vascular endothelium to shear stress: Potential role of ion channels and cellular cytoskeleton
3. The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development
4. Role of hemodynamics in pulmonary vascular remodeling: Implications for primary pulmonary hypertension
5. Systemic lobar shunting induces advanced pulmonary vasculopathy
6. Animal models of emphysema: The next generations
7. Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles
8. Identification and categorization of inducible mast cell genes in a subtraction library
9. The cartilage collagens: A review of their structure, organization, and role in the pathogenesis of experimental arthritis in animas and in human rheumatic disease
10. Apolipoprotein E and atherosclerosis
11. Effects of a chronic aortopulmonary shunt on pulmonary hemodynamics in piglets
12. Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: Importance of protein kinase C
13. Site-directed mutagenesis of human endothelial cell ecto-ADPase/soluble CD39: Requirement of glutamate 174 and serine 218 for enzyme activity and inhibition of platelet recruitment
14. Cytochrome P450 2C is an EDHF synthase in coronary arteries
15. Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production
16. Pulmonary vasomotor dysfunction is produced with chronically high pulmonary blood flow
17. Pulmonary hypertension
18. Improved Movat pentachrome stain
19. Induction of angiogenesis by cationic lipid-mediated VEGF 165 gene transfer in the rabbit ischemic hindlimb model
20. P-selectin participates in cardiopulmonary bypass-induced inflammatory response in association with nitric oxide and peroxynitrite production
21. The pathology of hypertensive pulmonary vascular disease. A description of six grades of structural changes in the pulmonary arteries with special reference to congenital cardiac septal defects
22. Expression of lipoprotein receptors in atherosclerotic lesions
23. E-selectin-dependent signaling via the mitogen-activated protein kinase pathway in vascular endothelial cells
24. Surgical implications of pulmonary hypertension in congenital heart disease
25. Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol
26. Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization
27. Endothelial cell dysfunction correlates differentially with survival in primary and secondary pulmonary hypertension
28. E/P-selectin-deficient mice: An optimal mutation for abrogating antigen but not tumor necrosis factor-alpha-induced immune responses
29. High-throughput analysis of gene expression in porcine pulmonary arteries after aorto-pulmonary anastomotic shunt to the left lower lobe
30. 1α,25-dihydroxyvitamin D3 up-regulates expression of the osteoclast integrin alpha v beta 3
31. Mutations in the caveloin-3 gene cause autosomal dominant limb-girdle muscular dystrophy
32. Congenital diaphragmatic hernia: Where are we and where do we go from here?
33. Effects of fibrinogen, fibrin and their degradation products on the behaviour of vascular smooth muscle cells
34. Effects of chronic pulmonary overcirculation on pulmonary vasomotor tone
35. The regulation of caveolin expression and localization by serum and heparin in vascular smooth muscle cells
36. Pulmonary hypertension: Pathophysiology as a basis for clinical decision making
37. EVE beyond, retro and prospective insights
38. Suppression of angiotensin-converting enzyme expression and activity by shear stress
39. Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression
40. Integrins
41. Embryonic lethal mutation in mice induced by retrovirus insertion into the α1(I) collagen gene
42. Oxysterols: Modulators of cholesterol metabolism and other processes
43. Chronic pulmonary hypertensionthe monocrotaline model and involvement of the hemostatic system
44. Sterol carrier protein-2
45. Application of cDNA microarrays in determining molecular phenotype in cardiac growth, development, and response to injury
46. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
47. Altered endothelium-dependent relaxations in lambs with high pulmonary blood flow and pulmonary hypertension
48. Hypoxia induces cell-specific changes in gene expression in vascular wall cells: Implications for pulmonary hypertension
49. Acute intrauterine pulmonary hypertension impairs endothelium-dependent vasodilation in the ovine fetus
50. The role of vascular injury and hemodynamics in rat pulmonary artery remodeling
51. Histopathology of pulmonary hypertension
52. Increased pulmonary blood flow produces endothelial cell dysfunction in neonatal swine
53. Cytochromes P450: A success story
54. Microarray analysis of Drosophila development during metamorphosis
55. Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties