Site-directed mutagenesis of human endothelial cell ecto-ADPase/soluble CD39: Requirement of glutamate 174 and serine 218 for enzyme activity and inhibition of platelet recruitment

Biochemistry

Volumn 39, Issue 23, 2000, Pages 6936-6943

  Drosopoulos, Joan H F ^a,b   Broekman, M Johan ^a,b   Islam, Naziba ^a,b   Maliszewski, Charles R ^c   Gayle III, Richard B ^c   Marcus, Aaron J ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APYRASE; GLUTAMIC ACID; SERINE;

AMINO ACID ANALYSIS; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; THROMBOCYTE AGGREGATION;

ADENOSINE TRIPHOSPHATASES; AMINO ACID SEQUENCE; ANTIGENS, CD; APYRASE; BLOOD PLATELETS; CATIONS, DIVALENT; CONSERVED SEQUENCE; ENDOPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEPHELOMETRY AND TURBIDIMETRY; PLATELET AGGREGATION; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SOLUBILITY;

EID: 0034643922     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992581e     Document Type: Article

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