Mechanisms for LEPR-mediated regulation of leptin expression in brown and white adipocytes in rat pups

Physiological Genomics

Volumn 2001, Issue 4, 2001, Pages 189-199

  Zhang, Yiying ^a,c   Hufnagel, Carmen ^b   Eiden, Sandra ^b   Guo, Kai Ying ^a   Diaz, Patricia A ^a   Leibel, Rudolph L ^a   Schmidt, Ingrid ^b  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Adipose tissue; Energy metabolism; Leptin receptor; Obesity; Sympathetic nervous system

Indexed keywords

CARRIER PROTEIN; CELL SURFACE RECEPTOR; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

ADIPOCYTE; ADIPOSE TISSUE; ADRENERGIC SYSTEM; ANIMAL; ARTICLE; BLOOD; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CYTOLOGY; ENERGY METABOLISM; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETICS; GENOTYPE; MALE; METABOLISM; MULTIVARIATE ANALYSIS; NEWBORN; PHYSIOLOGY; RAT; REGRESSION ANALYSIS; ZUCKER RAT;

ADIPOCYTES; ADIPOSE TISSUE; ADIPOSE TISSUE, BROWN; ANIMALS; ANIMALS, NEWBORN; CARRIER PROTEINS; ENERGY INTAKE; ENERGY METABOLISM; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION; GENOTYPE; LEPTIN; MALE; MULTIVARIATE ANALYSIS; RATS; RATS, ZUCKER; RECEPTORS, CELL SURFACE; REGRESSION ANALYSIS; RNA, MESSENGER; SYMPATHETIC NERVOUS SYSTEM;

EID: 0347709124     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.2001.4.3.189     Document Type: Article

References (56)

1. Ashwell M, Holt S, Jennings G, Stirling DM, Trayhurn P, and York DA. Measurement by radioimmunoassay of the mitochondrial uncoupling protein from brown adipose tissue of obese (ob/ob) mice and Zucker (fa/fa) rats at different ages. FEBS Lett 179: 233-237, 1985.
2. Bamshad M, Song CK, and Bartness TJ. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol Regulatory Integrative Comp Physiol 276: R1569-R1578, 1999.
3. Bartness TJ and Bamshad M. Innervation of mammalian white adipose tissue: implications for the regulation of total body fat. Am J Physiol Regulatory Integrative Comp Physiol 275: R1399-R411, 1998.
4. Broman M and Kallskog O. The effects of hypothermia on renal function and haemodynamics in the rat. Acta Physiol Scand 153: 179-184, 1995.
5. Campfield LA, Smith FJ, Guisez Y, Devos R, and Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
6. Chapman BJ, Withey WR, and Munday KA. Autoregulation of renal blood flow in dogs at normal body temperature and at 27 degrees C. Clin Sci Mol Med Suppl 48: 501-508, 1975.
7. Chua, SC Jr, White DW, Wu-Peng XS, Liu SM, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, and Leibel RL. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45: 1141-1143, 1996.
8. Chung WK, Belfi K, Chua M, Wiley J, Mackintosh R, Nicolson M, Boozer CN, and Leibel RL. Heterozygosity for Lep(ob) or Lepr(db) affects body composition and leptin homeostasis in adult mice. Am J Physiol Regulatory Integrative Comp Physiol 274: R985-R990, 1998.
9. Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, and Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 138: 797-804, 1997.
10. Coleman DL. Thermogenesis in diabetes-obesity syndromes in mutant mice. Diabetologia 22: 205-111, 1982.
11. Cumin F, Baum HP, and Levens N. Mechanism of leptin removal from the circulation by the kidney. J Endocrinol 155: 577-585, 1997.
12. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, and Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes 45: 1446-1450, 1996.
13. Deng C, Moinat M, Curtis L, Nadakal A, Preitner F, Boss O, Assimacopoulos-Jeannet F, Seydoux J, and Giacobino JP. Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Endocrinology 138: 548-552, 1997.
14. Dessolin S, Schalling M, Champigny O, Lonnqvist F, Ailhaud G, Dani C, and Ricquier D. Leptin gene is expressed in rat brown adipose tissue at birth. FASEB J 11: 382-387, 1997.
15. Devaskar SU, Ollesch C, Rajakumar RA, and Rajakumar PA. Developmental changes in ob gene expression and circulating leptin peptide concentrations. Biochem Biophys Res Commun 238: 44-47, 1997.
16. Doring H, Kortner G, Meyer K, and Schmidt I. Do changes of sympathetically stimulated thermogenesis underlie the developmental changes in the cold defense of rat pups? In: Integrative and Cellular Aspects of Autonomic Functions: Temperature and Osmoregulation, edited by Pleschka K and Gerstberger R. London: Libbey, 1994, p. 285-294.
17. Evans BA, Agar L, and Summers RJ. The role of the sympathetic nervous system in the regulation of leptin synthesis in C57BL/6 mice. FEBS Lett 444: 149-154, 1999.
18. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, and Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1: 1311-1314, 1995.
19. Fruhbeck G, Aguado M, and Martinez JA. In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 240: 590-594, 1997.
20. Kaul R, Heldmaier G, and Schmidt I. Defective thermoregulatory thermogenesis does not cause onset of obesity in Zucker rats. Am J Physiol Endocrinol Metab 259: E11-E18, 1990.
21. Kortner G, Petrova O, Vogt S, and Schmidt I. Sympathetically and nonsympathetically mediated onset of excess fat deposition in Zucker rats. Am J Physiol Endocrinol Metab 267: E947-E953, 1994.
22. Kortner G, Schildhauer K, Petrova O, and Schmidt I. Rapid changes in metabolic cold defense and GDP binding to brown adipose tissue mitochondria of rat pups. Am J Physiol Regulatory Integrative Comp Physiol 264: R1017-R1023, 1993.
23. Kosaki A, Yamada K, and Kuzuya H. Reduced expression of the leptin gene (ob) by catecholamine through a G(S) protein-coupled pathway in 3T3-L1 adipocytes. Diabetes 45: 1744-1749, 1996.
24. Kraeft S, Schwarzer K, Eiden S, Nuesslein-Hildesheim B, Preibisch G, and Schmidt I. Leptin responsiveness and gene dosage for leptin receptor mutation (fa) in newborn rats. Am J Physiol Endocrinol Metab 276: E836-E842, 1999.
25. Maffei M, Fei H, Lee GH, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, and Friedman JM. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 92: 6957-6960, 1995.
26. Markewicz B, Kuhmichel G, and Schmidt I. Onset of excess fat deposition in Zucker rats with and without decreased thermogenesis. Am J Physiol Endocrinol Metab 265: E478-E486, 1993.
27. May JM. Rat adipocyte utilization of different substrates: effects of cell size and the control of lipogenesis. Lipids 17: 626-633, 1982.
28. Meierfrankenfeld B, Abelenda M, Jauker H, Klingenspor M, Kershaw EE, Chua SC Jr, Leibel RL, and Schmidt I. Perinatal energy stores and excessive fat deposition in genetically obese (fa/fa) rats. Am J Physiol Endocrinol Metab 270: E700-E708, 1996.
29. Moinat M, Deng C, Muzzin P, Assimacopoulos-Jeannet F, Seydoux J, Dulloo AG, and Giacobino JP. Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Lett 373: 131-134, 1995.
30. Nuesslein B, Petrova O, Schildhauer K, and Schmidt I. Morning depression of cold defense in juvenile rats. In: Integrative and Cellular Aspects of Autonomic Functions: Temperature and Osmoregulation, edited by Pleschka K and Gerstberger R. London: Libbey, 1994, p. 285-294.
31. Nuesslein B and Schmidt I. Development of circadian cycle of core temperature in juvenile rats. Am J Physiol Regulatory Integrative Comp Physiol 259: R270-R276, 1990.
32. Planche E, Joliff M, de Gasquet P, and Leliepvre X. Evidence of a defect in energy expenditure in 7-day-old Zucker rat (fa/fa). Am J Physiol Endocrinol Metab 245: E107-E113, 1983.
33. Redlin U, Nuesslein B, and Schmidt I. Circadian changes of brown adipose tissue thermogenesis in juvenile rats. Am J Physiol Regulatory Integrative Comp Physiol 262: R504-R508, 1992.
34. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, and Leibel RL. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81: 3424-3427, 1996.
35. Schmidt I. The role of juvenile thermoregulatory thermogenesis in the development of normal energy balance or obesity. In: Thermotherapy for Neoplasia, Inflammation and Pain, edited by Kosaka M, Sugahara T, Schmidt KL, and Simon E. Tokyo: Springer Verlag, 2000.
36. Schmidt I, Kaul R, and Heldmaier G. Thermoregulation and diurnal rhythms in 1-week-old rat pups. Can J Physiol Pharmacol 65: 1355-1364, 1987.
37. Schwartz MW, Peskind E, Raskind M, Boyko EJ, and Porte D Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med 2: 589-593, 1996.
38. Schwartz MW, Seeley RJ, Campfield LA, Burn P, and Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106, 1996.
39. Schwarzer K, Doring H, and Schmidt I. Different physiological traits underlying increased body fat of fatty (fa/fa) and heterozygous (+/fa) rats. Am J Physiol Endocrinol Metab 272: E100-E106, 1997.
40. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, and Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94: 4637-4641, 1997.
41. Shimazu T. Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia 20: 343-356, 1981.
42. Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE, Boss O, Pernin A, Chin WW, Cusin I, Rohner-Jeanrenaud F, Burger AG, Zapf J, and Meier CA. Direct effects of leptin on brown and white adipose tissue. J Clin Invest 100: 2858-2864, 1997.
43. Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, La-Quier F, Manetta J, Bue-Valleskey J, and Stephens TW. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271: 5301-5304, 1996.
44. Stehling O, Doring H, Ertl J, Preibisch G, and Schmidt I. Leptin reduces juvenile fat stores by altering the circadian cycle of energy expenditure. Am J Physiol Regulatory Integrative Comp Physiol 271: R1770-1774, 1996.
45. Stehling O, Doring H, Nuesslein-Hildesheim B, Olbort M, and Schmidt I. Leptin does not reduce body fat content but augments cold defense abilities in thermoneutrally reared rat pups. Pflügers Arch 434: 694-697, 1997.
46. Tai TAC, Jennermann C, Brown KK, Oliver BB, MacGinnitie MA, Wilkison WO, Brown HR, Lehmann JM, Kliewer SA, Morris DC, and Graves RA. Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation. J Biol Chem 271: 29909-29914, 1996.
47. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muri C, Sanker S, Moriarty A, Moore K, Smutko JS, Mays GG, Woolf EA, Monroe CA, and Tepper RI. Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263-1271, 1995.
48. Trayhurn P, Duncan JS, Rayner DV, and Hardie LJ. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem Biophys Res Commun 228: 605-610, 1996.
49. Truett GE, Tempelman RJ, and Walker JA. Codominant effects of the fatty (fa) gene during early development of obesity. Am J Physiol Endocrinol Metab 268: E15-E20, 1995.
50. 125-leptin administration to ob/ob and db/db mice. Horm Metab Res 28: 653-658, 1996.
51. Wang J, Liu R, Hawkins M, Barzilai N, and Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393: 684-688, 1998.
52. Wang J, Liu R, Liu L, Chowdhury R, Barzilai N, Tan J, and Rossetti L. The effect of leptin on Lep expression is tissue-specific and nutritionally regulated. Nat Med 5: 895-899, 1999.
53. Young JB and Landsberg L. Diminished sympathetic nervous system activity in genetically obese (06/06) mouse. Am J Physiol Endocrinol Metab 245: E148-E154, 1983.
54. Zhang Y, Olbort M, Schwarzer K, Nuesslein-Hildesheim B, Nicolson M, Murphy E, Kowalski TJ, Schmidt I, and Leibel RL. The leptin receptor mediates apparent autocrine regulation of leptin gene expression. Biochem Biophys Res Commun 240: 492-495, 1997.
55. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, and Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.
56. Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB, and Unger RH. Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 94: 6386-6390, 1997.