Update on genetics of inflammatory bowel disease

Current Opinion in Gastroenterology

Volumn 18, Issue 4, 2002, Pages 410-415

  Hugot, Jean Pierre ^a   Cho, Judy H ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; GENE PRODUCT; HLA B ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; UNCLASSIFIED DRUG;

CHROMOSOMAL LOCALIZATION; CROHN DISEASE; ENTERITIS; ENVIRONMENTAL FACTOR; GENE MUTATION; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOMICS; HEREDITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; MONOCYTE; ONSET AGE; PENETRANCE; REVIEW; SYNDROME;

EID: 0036082259     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001574-200207000-00003     Document Type: Review

References (46)

1. Genetic markers may predict disease behaviour in patients with ulcerative colitis
2. HLA-DRB1 *03, but not the TNFα-308 promoter gene polymorphism, confers protection against fistulizing Crohn's disease
3. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL
4. The molecular classification of the clinical manifestations of Crohn's disease
5. Peripheral arthropathies in inflammatory bowel disease: Their articular distribution and natural history
6. Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease
7. Crohn's disease-associated genetic marker is seen in medically unresponsive ulcerative colitis patients and may be associated with pouch-specific complications
8. Tumour necrosis factor (TNF) gene polymorphism in Crohn's disease (CD): Influence on disease behaviour?
9. Genetic markers in clinically well defined patients with ulcerative colitis (UC)
10. Mapping of a suspitibility locus for Crohn's disease on chromosome 16
11. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12
12. A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
13. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
14. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: Evidence for epistasis between 1p and IBD1
15. High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
16. A genome-wide search identifies potential new susceptibility loci for Crohn's disease
17. Genetic analysis in Italian families with inflammatory bowel disease supports linkage to the IBD1 locus - A GISC study
18. Analysis of Australian Crohn's disease pedigrees refines the localization for susceptibility to inflammatory bowel disease on chromosome 16
19. The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease
20. Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis
21. American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12
22. Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16
23. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16
24. Genetic analyses of chromosome 12 loci in Crohn's disease
25. Genetic analysis in Finnish families with inflammatory bowel disease supports linkage to chromosome 3p21
26. Linkage of inflammatory bowel disease to human chromosome 6p
27. Replication and extension studies of inflammatory bowel disease susceptibility regions confirm linkage to chromosome 6p (IBD3)
28. Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12
29. Linkage and association between inflammatory bowel disease and a locus on chromosome 12
30. Exclusion of linkage of Crohn's disease to previously reported regions on chromosomes 12, 7, and 3 in the Belgian population indicates genetic heterogeneity
31. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16
32. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
33. Evidence for a NOD2-independent susceptibility locus for inflammatory bowel disease on chromosome 16p
34. Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease
35. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
36. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
37. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
38. Human Nod1 confers responsiveness to bacterial lipopolysaccharides
39. Innate immunity
40. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
41. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
42. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
43. NOD2/CARD15 does not influence response to infliximab in Crohn's disease
44. CARD15 mutations in Blau syndrome
45. Ulcerative colitis and Crohn's disease: Distinctive gene expression profiles and novel susceptibility candidate genes
46. Analysis of mucosal gene expression in inflammatory bowel disease parallel oligonucleotide arrays