Tumour necrosis factor (TNF) gene polymorphism in Crohn's disease (CD): Influence on disease behaviour?

Clinical and Experimental Immunology

Volumn 119, Issue 1, 2000, Pages 64-68

  Louis, E ^a   Peeters, M ^a,b   Franchimont, D ^a   Seidel, L ^a   Fontaine, F ^a,c   Demolin, G ^a   Croes, F ^a   Dupont, P ^a   Davin, L ^a   Omri, S ^a   Rutgeerts, P ^a,b   Belaiche, J ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Leuven   (Belgium)

^c Clinique Saint Joseph   (Belgium)

Author keywords

Crohn's disease; Genetics; Tumour necrosis factor alpha

Indexed keywords

TUMOR NECROSIS FACTOR;

ALLELISM; ARTICLE; COLON BIOPSY; CONTROLLED STUDY; CROHN DISEASE; FEMALE; GENETIC HETEROGENEITY; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; COLON; CROHN DISEASE; FEMALE; GENOTYPE; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); STEROIDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033959486     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2000.01106.x     Document Type: Article

References (33)

1. 1 Satsangi J, Jewell DP, Rosenberg WMC, Bell JI. Genetics of inflammatory bowel disease. Gut 1994; 35:696-700.
2. 2 Tysk C, Lindberg E, Järnerot G, Floderus-Myrhed B. Ulcerative colitis and Crohn's disease in an unselected population of monozygotic and dizygotic twins. A study of heritability and the influence of smoking. Gut 1988; 28:990-6.
3. 3 Hugot JP, Laurent-Puig P, Gower-Rousseau C et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996; 379:821-3.
4. 4 Satsangi J, Parkes M, Louis E et al. Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nature Genetics 1996; 14:199-202.
5. 5 Peeters M, Nevens H, Baert F, Hiele M, De Meyer AM, Vlietinck R, Rutgeerts P. Familial aggregation in Crohn's disease: increased aged-adjusted risk and concordance in clinical characteristics. Gastroenterology 1996; 111:597-603.
6. 6 Colombel JF, Grandbastien B, Gower-Rousseau C et al. Clinical charateristics of Crohn's disease in 72 families. Gastroenterology 1996; 111:604-7.
7. 7 Bouma G, Poen AC, Garcia-Gonzalez MA, Schreuder GMT, Felt-Bersma RJF, Meuwissen SGM, Pena AS. HLA-DRBI *03, but not the TNFA-308 promoter gene polymorphism, confers protection against fistulising Crohn's disease. Immunogenetics 1998; 47:451-5.
8. 8 Plevy SE, Taylor K, De Woody KL, Schaible TF, Shealy D, Targan SR. Tumor necrosis factor (TNF) microsatellite haplotypes and perinuclear anti-neutrophil cytoplasmic antibody (pANCA) identify Crohn's disease (CD) patients with poor clinical response to anti-TNF monoclonal antibody (cA2). Gastroenterology 1997; 112:A1062.
9. 9 Heresbach D, Alizadeh M, Bretagne JF et al. TAP gene transporter polymorphism in inflammatory bowel diseases. Scand J Gastroenterol 1997; 32:1022-7.
10. 10 Dionne S, Hiscott J, D'Agata I, Duhaime A, Seidman EG. Quantitative PCR analysis of TNF-α and IL-1β mRNA levels in pediatric IBD mucosal biopsies. Dig Dis Sci 1997; 42:1557-66.
11. 11 Reinecker HC, Steffen M, Witthoeft T, Pflueger I, Schreiber S, MacDermott RP. Enhanced secretion of tumor necrosis factor-alpha, IL-6 and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993; 94:174-81.
12. 12 Stack WA, Mann SD, Roy AJ et al. Randomised controlled trial of CDP571 antibody to tumour necrosis factor-α in Crohn's disease. Lancet 1997; 349:521-4.
13. 13 Targan SR, Hanauer SB, Van Deventer SJH et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N Engl J Med 1997; 337:1029-35.
14. 14 Mansfield JC, Holden H, Tarlow JK, Di Giovine FS, McDowell TL, Wilson AG, Holdsworth CD, Duff GW. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994; 106:637-42.
15. 15 Bouma G, Xia B, Crusius JBA, Bioque G, Koutroubakis I, Von Blomberg VME, Meuwissen SGM, Pena AS. Distribution of four polymorphisms in the tumor necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD). Clin Exp Immunol 1996; 103:391-6.
16. 16 Louis E, Satsangi J, Roussomoustakaki M, Parkes M, Fanning G, Welsh K, Jewell DP. Cytokine gene polymorphisms in inflammatory bowel disease. Gut 1996; 39:705-10.
17. 17 Plevy SE, Targan SR, Yang H, Fernandez D, Rotter JI, Toyoda H. Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6. Gastroenterology 1996; 110: 1053-60.
18. 18 Heresbach D, Ababou A, Bourienne A et al. Tumor necrosis factor gene and microsatellite polymorphism in chronic inflammatory bowel diseases. Gastroenterol Clin Biol 1997; 21:555-61.
19. 19 Wilson AG, Symons JA, McDowel TL, McDevitt HO, Duff GW. Effect of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc Natl Acad Sci USA 1997; 94:3195-9.
20. 20 Bouma G, Crusius JBA, Oudkerk Pool M et al. Secretion of tumor necrosis factor α and lymphotoxin α in relation to polymorphisms in the TNF genes and HLA-DR alleles. Relevance for inflammatory bowel disease. Scand J Immunol 1996; 43:456-63.
21. 21 Louis E, Franchimont D, Piron A et al. Tumor necrosis factor gene polymorphism influences tumor necrosis factor α production in LPS-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998; 113:401-6.
22. 22 Bunce M, Taylor CJ, Welsh KI. Rapid HLA-DQB typing by eight PCR amplifications with sequence-specific primers (PCR-SSP). Human Immunol 1993; 37:201-6.
23. 23 Reimund JM, Wittersheim C, Dumont S, Muller CD, Kenney JS, Baumann R, Poindron P, Duclos B. Increased production of tumor necrosis factor-α, interleukin-1β and interleukin-6 by morphologically normal intestinal biopsies from patients with Crohn's disease. Gut 1996; 39:684-9.
24. 24 Wardle TD, Hall L, Turnberg LA. Use of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease. Gut 1992; 33:1644-51.
25. 25 Riley SA, Mani V, Goodman MJ, Dutt S, Herd ME. Microscopic activity in ulcerative colitis: what does it mean? Gut 1991; 32:174-8.
26. 26 Sher ER, Leung DYM, Surs W, Kam JC, Zieg G, Kamada AK, Harbeck R, Szefler SJ. Steroid resistant asthma: cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994; 93:33-9.
27. 27 Van der Burg B, Liden J, Okret S, Delaunay F, Wissink S, Van der Saag PT, Gustafsson JA. Nuclear factor-κB repression in anti-inflammation and immunosuppression by glucocorticoids. Trends Endocrinol Metab 1997; 8:152-7.
28. 28 McGuire W, Hill AVS, Allsopp CEM, Greenwood BM, Kiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 1994; 371:508-11.
29. 29 Conway DJ, Holand MJ, Bailey RL, Campbell AE, Mahdi OMS, Jennings R, Mibena E, Mabey DCW. Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-α) gene promoter and with elevated TNF-α levels in tear fluid. Infect Immun 1997; 65:1003-6.
30. 30 Brinkman BM, Zuijdeest D, Kaijzel EL, Breedveld FC, Verweij CL. Relevance of the tumor necrosis factor alpha (TNF alpha) - 308 promoter polymorphism in TNF alpha gene regulation. J Inflamm 1995; 46:32-41.
31. 31 Westendorp RGJ, Langermans JAM, Huizinga TWJ, Elouali AH, Verwij CL, Boomsma DI, Vandenbroucke JP. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997; 349:170-3.
32. 32 Wilson AG, De Vries N, Pociot F, Di Giovine FS, Van der Putte LBA, Duff GW. An allelic polymorphism within the human tumor necrosis factor α promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med 1993; 177:557-60.
33. 33 Roy S, McGuire W, Mascie-Taylor CGN, Saha B, Hazra SK, Hill AVS, Kiatkowski D. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy. J Infect Dis 1997; 176:530-2.