Crohn's Disease-Associated Genetic Marker is Seen in Medically Unresponsive Ulcerative Colitis Patients and May Be Associated with Pouch-Specific Complications

Diseases of the Colon and Rectum

Volumn 42, Issue 5, 1999, Pages 605-606

  Achkar, Jean Paul ^a   Lashner, Bret A ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; COLON CROHN DISEASE; COLON RESECTION; DISEASE ASSOCIATION; FEMALE; GENETIC LINKAGE; HAPLOTYPE; HUMAN; ILEUM POUCH; MALE; MARKER GENE; POSTOPERATIVE COMPLICATION; RECURRENCE RISK; RISK ASSESSMENT; TREATMENT OUTCOME; ULCERATIVE COLITIS;

ADULT; ALLELES; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; GENETIC MARKERS; HAPLOTYPES; HUMANS; MALE; MICROSATELLITE REPEATS; PHENOTYPE; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATIONS; PROCTOCOLECTOMY, RESTORATIVE; PROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032912297     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/bf02234134     Document Type: Article

References (9)

1. Satsangi J, Parkes M, Louis E, et al. Two stage genomewide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12. Nat Genet 1996;14:199-202.
2. Hugot JP, Laurent-Puig P, Gower-Rousseau C, et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996;379:821-3.
3. Duerr RH, Barmada MM, Zhang L, et al. Linkage and association between inflammatory bowel disease and a locus on chromosome 12. Am J Hum Genet 1998;63:95-100.
4. Cho JH, Nicolae DL, Gold LH, et al. Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci U S A 1998;95:7502-7.
5. Plevy SE, Targan SR, Yang H, Fernandez D, Rotter JI, Toyoda H. Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6. Gastroenterology 1996;110:1053-60.
6. Plevy SE, Vasiliauskas EA, Taylor K, et al. The Crohn's disease associated tumor necrosis factor (TNF) microsatellite a2b1c2d4e1 haplotype and anti-saccharomyces cervisiae antibody (ASCA) define medically resistant forms of ulcerative colitis [abstract]. Gastroenterology 1997;112:A1062.
7. Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT. Location of tumor necrosis factor α by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993;34:1705-9.
8. Stack WA, Mann SD, Roy AJ, et al. Randomized controlled trial of CDP571 antibody to tumor necrosis factor-α in Crohn's disease. Lancet 1997;349:521-4.
9. Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. N Engl J Med 1997;337:1029-35.