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Volumn 11, Issue 12, 1997, Pages 937-945

Genetics of human obesity: Research directions

Author keywords

Body fat; Food intake; Genome scanning; Leptin; Mendelian disorder; QTL; Single gene defect; Transgenic model

Indexed keywords

AMINO ACID COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; CROSS BREEDING; DIETARY INTAKE; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; GENETICS; HUMAN; MOLECULAR RECOGNITION; MUSCLE METABOLISM; OBESITY; PRIORITY JOURNAL; REVIEW;

EID: 0030867806     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.11.12.9337146     Document Type: Review
Times cited : (39)

References (56)
  • 1
    • 0342706431 scopus 로고    scopus 로고
    • The causes of obesity: Advances in molecular biology but stagnation on the genetic front
    • In press
    • Bouchard, C. (1997) The causes of obesity: advances in molecular biology but stagnation on the genetic front. Diabetologia In press
    • (1997) Diabetologia
    • Bouchard, C.1
  • 6
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman, D. L. (1978) Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice (review). Diabetologia 14, 141-148
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 7
    • 0029048408 scopus 로고
    • Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
    • Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., and Burn, P. (1995) Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549
    • (1995) Science , vol.269 , pp. 546-549
    • Campfield, L.A.1    Smith, F.J.2    Guisez, Y.3    Devos, R.4    Burn, P.5
  • 8
    • 0030010388 scopus 로고    scopus 로고
    • Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
    • Chehab, F. E., Lim, M. E., and Lu, R. H. (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12, 318-320
    • (1996) Nature Genet. , vol.12 , pp. 318-320
    • Chehab, F.E.1    Lim, M.E.2    Lu, R.H.3
  • 12
    • 0029969957 scopus 로고    scopus 로고
    • Leptin and leptinomania
    • Bray, G. A. (1996) Leptin and leptinomania. Lancet 348, 140-141
    • (1996) Lancet , vol.348 , pp. 140-141
    • Bray, G.A.1
  • 13
    • 85047677586 scopus 로고    scopus 로고
    • Leptin and clinical medicine: A new piece in the puzzle of obesity
    • In press
    • Bray, G. A., and York, D. A. (1997) Leptin and clinical medicine: a new piece in the puzzle of obesity. J. Clin. Endocrinol. Metab. In press
    • (1997) J. Clin. Endocrinol. Metab.
    • Bray, G.A.1    York, D.A.2
  • 14
    • 0342271330 scopus 로고
    • Identification of new genes contributing to atherosclerosis: The mapping of genes contributing to complex disorders in animal models
    • (Lusis, A. J., Rotter, J. I., and Sparkes, R. S., eds) Karger, Basel
    • Warden, C. H., Daluiski, A., and Lusis, A. J. (1992) Identification of new genes contributing to atherosclerosis: the mapping of genes contributing to complex disorders in animal models. In Molecular Genetics of Coronary Artery Disease. Monographs in Human Genetics (Lusis, A. J., Rotter, J. I., and Sparkes, R. S., eds) pp. 419-441, Karger, Basel
    • (1992) Molecular Genetics of Coronary Artery Disease. Monographs in Human Genetics , pp. 419-441
    • Warden, C.H.1    Daluiski, A.2    Lusis, A.J.3
  • 15
    • 0024508964 scopus 로고
    • Mendelian factors underlying quantitative traits using RFLP linkage maps
    • Lander, E. S., and Botstein, D. (1989) Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199
    • (1989) Genetics , vol.121 , pp. 185-199
    • Lander, E.S.1    Botstein, D.2
  • 16
    • 0030279364 scopus 로고    scopus 로고
    • Genetics of obesity: Advances from rodent studies
    • Chagnon, Y. C., and Bouchard, C. (1996) Genetics of obesity: advances from rodent studies. Trends Genet. 12, 441-444
    • (1996) Trends Genet. , vol.12 , pp. 441-444
    • Chagnon, Y.C.1    Bouchard, C.2
  • 17
    • 0028937971 scopus 로고
    • Identification of four chromosomal loci determining obesity in a multifactorial mouse model
    • Warden, C. H., Fisler, J. S., and Shoemaker, S. M. (1995) Identification of four chromosomal loci determining obesity in a multifactorial mouse model. J. Clin. Invest. 95, 1545-1552
    • (1995) J. Clin. Invest. , vol.95 , pp. 1545-1552
    • Warden, C.H.1    Fisler, J.S.2    Shoemaker, S.M.3
  • 18
    • 0028075287 scopus 로고
    • Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model
    • West, D. B., Goudey-Lefevre, J., York, B., and Truett, G. E. (1994) Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J. Clin. Invest. 94, 1410-1416
    • (1994) J. Clin. Invest. , vol.94 , pp. 1410-1416
    • West, D.B.1    Goudey-Lefevre, J.2    York, B.3    Truett, G.E.4
  • 22
    • 0029688887 scopus 로고    scopus 로고
    • Current status of the human obesity gene map
    • Bouchard, C., and Pérusse, L. (1996) Current status of the human obesity gene map. Obes. Res. 4, 81-90
    • (1996) Obes. Res. , vol.4 , pp. 81-90
    • Bouchard, C.1    Pérusse, L.2
  • 23
    • 0029157769 scopus 로고
    • Human obesity does not segregate with the chromosomal regions of Prader-Willi, Bardet-Biedl, Cohen, Borjeson or Wilson-Turner syndromes
    • Reed, D. R., Ding, Y., Xu, W., Cather, C., and Price, R. A. (1995) Human obesity does not segregate with the chromosomal regions of Prader-Willi, Bardet-Biedl, Cohen, Borjeson or Wilson-Turner syndromes. Int. J. Obes. 19, 599-603
    • (1995) Int. J. Obes. , vol.19 , pp. 599-603
    • Reed, D.R.1    Ding, Y.2    Xu, W.3    Cather, C.4    Price, R.A.5
  • 24
    • 0029148426 scopus 로고
    • Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
    • Katz, E. B., Stenbit, A. E., Hatton, K., DePinho, R., and Charron, M. J. (1995) Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature (London) 377, 151-155
    • (1995) Nature (London) , vol.377 , pp. 151-155
    • Katz, E.B.1    Stenbit, A.E.2    Hatton, K.3    DePinho, R.4    Charron, M.J.5
  • 25
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky, J., Clarke, G., Enerback, S., Spiegelman, B., and Kozak, L. P. (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96, 2914-2923
    • (1995) J. Clin. Invest. , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 26
    • 0029142737 scopus 로고
    • Muscle-specific overexpression of lipoprotein-lapse causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice
    • Levak-Frank, S., Radner, H., Walsh, A., Stolberg, R., Knipping, G., Hoefler, G., Sattler, W., Weinstoc, P. H., Breslow, J. L., and Zechner, R. (1995) Muscle-specific overexpression of lipoprotein-lapse causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J. Clin. Invest. 96, 976-986
    • (1995) J. Clin. Invest. , vol.96 , pp. 976-986
    • Levak-Frank, S.1    Radner, H.2    Walsh, A.3    Stolberg, R.4    Knipping, G.5    Hoefler, G.6    Sattler, W.7    Weinstoc, P.H.8    Breslow, J.L.9    Zechner, R.10
  • 27
    • 4244149331 scopus 로고
    • Development of morbid obesity in transgenic mice following the genetic ablation of brown adipose tissue
    • abstr.
    • Lowell, B. B., Susulic, V. S., Hamann, A., Lawitts, J., Boyer, B., Kozak, L. P., and Flier, J. S. (1993) Development of morbid obesity in transgenic mice following the genetic ablation of brown adipose tissue. Clin. Res. 41, 260A (abstr.)
    • (1993) Clin. Res. , vol.41
    • Lowell, B.B.1    Susulic, V.S.2    Hamann, A.3    Lawitts, J.4    Boyer, B.5    Kozak, L.P.6    Flier, J.S.7
  • 28
    • 0027236077 scopus 로고
    • Energy balance and lipid metabolism in transgenic mice bearing an antisense GCR gene construct
    • Richard, D., Chapdelaine, S., Deshaies, Y., Pépin, M. C., and Barden, N. (1993) Energy balance and lipid metabolism in transgenic mice bearing an antisense GCR gene construct. Am. J. Physiol. 265, R146-R150
    • (1993) Am. J. Physiol. , vol.265
    • Richard, D.1    Chapdelaine, S.2    Deshaies, Y.3    Pépin, M.C.4    Barden, N.5
  • 29
    • 0027453501 scopus 로고
    • Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose-tissue
    • Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H. M., Leach, F., and Kahn, B. B. (1993) Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose-tissue (technical note). J. Biol. Chem. 268, 2243-2246
    • (1993) J. Biol. Chem. , vol.268 , pp. 2243-2246
    • Shepherd, P.R.1    Gnudi, L.2    Tozzo, E.3    Yang, H.M.4    Leach, F.5    Kahn, B.B.6
  • 30
    • 0026659272 scopus 로고
    • Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice
    • Stenzel-Poore, M. P., Cameron, V. A., Vaughan, J., Sawchenko, P. E., and Vale, W. (1992) Development of Cushing's syndrome in corticotropin-releasing factor transgenic mice. Endocrinology 130, 3378-3386
    • (1992) Endocrinology , vol.130 , pp. 3378-3386
    • Stenzel-Poore, M.P.1    Cameron, V.A.2    Vaughan, J.3    Sawchenko, P.E.4    Vale, W.5
  • 32
    • 0025937117 scopus 로고
    • Reciprocal relation between the sympathetic nervous system and food intake
    • Bray, G.A. (1991) Reciprocal relation between the sympathetic nervous system and food intake. Brain Res. Bull. 27, 517-520
    • (1991) Brain Res. Bull. , vol.27 , pp. 517-520
    • Bray, G.A.1
  • 34
    • 0029145667 scopus 로고
    • Linkage between obesity and a marker near the tumor necrosis factor-locus in Pima Indians
    • Norman, R. A., Bogardus, C., and Ravussin, E. (1995) Linkage between obesity and a marker near the tumor necrosis factor-locus in Pima Indians. J. Clin. Invest. 96, 158-162
    • (1995) J. Clin. Invest. , vol.96 , pp. 158-162
    • Norman, R.A.1    Bogardus, C.2    Ravussin, E.3
  • 37
    • 0000082145 scopus 로고
    • An exploratory investigation of genetic linkage with body composition and fatness phenotypes: The Quebec Family Study
    • Borecki, I. B., Rice, T., Pérusse, L., Bouchard, C., and Rao, D. C. (1994) An exploratory investigation of genetic linkage with body composition and fatness phenotypes: the Quebec Family Study. Obes. Res. 2, 213-219
    • (1994) Obes. Res. , vol.2 , pp. 213-219
    • Borecki, I.B.1    Rice, T.2    Pérusse, L.3    Bouchard, C.4    Rao, D.C.5
  • 38
    • 0029938057 scopus 로고    scopus 로고
    • Extreme obesity may be linked to markers flanking the human OB gene
    • Reed, D. R., Ding, Y., Xu, W., Cather, C., Green, E. D., and Price, R. A. (1996) Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45, 691-694
    • (1996) Diabetes , vol.45 , pp. 691-694
    • Reed, D.R.1    Ding, Y.2    Xu, W.3    Cather, C.4    Green, E.D.5    Price, R.A.6
  • 41
  • 44
    • 0029984828 scopus 로고    scopus 로고
    • Bromocriptine (Ergoset) reduces body weight and improves glucose tolerance in obese subjects
    • Cincotta, A. H., and Meier, A. H. (1996) Bromocriptine (Ergoset) reduces body weight and improves glucose tolerance in obese subjects. Diabetes Care 19, 667-670
    • (1996) Diabetes Care , vol.19 , pp. 667-670
    • Cincotta, A.H.1    Meier, A.H.2
  • 46
    • 0029400218 scopus 로고
    • Brain peptides and obesity: Pharmacologic treatment
    • Leibowitz, S. F. (1995) Brain peptides and obesity: Pharmacologic treatment. Obes. Res. 3, 573S-589S
    • (1995) Obes. Res. , vol.3
    • Leibowitz, S.F.1
  • 48
    • 0030005010 scopus 로고    scopus 로고
    • Autoregulation of body-composition during weight recovery in human - The Minnesota Experiment revisited
    • Dulloo, A.G., Jacquet, J., and Girardier, L. (1996) Autoregulation of body-composition during weight recovery in human - The Minnesota Experiment revisited. Int. J. Obes. 20, 393-405
    • (1996) Int. J. Obes. , vol.20 , pp. 393-405
    • Dulloo, A.G.1    Jacquet, J.2    Girardier, L.3
  • 51
    • 0025148434 scopus 로고
    • Pancreatic glucagon signals postprandial satiety
    • Geary, N. (1990) Pancreatic glucagon signals postprandial satiety. Neurosci. Biobehav. Rev. 14, 323-338
    • (1990) Neurosci. Biobehav. Rev. , vol.14 , pp. 323-338
    • Geary, N.1
  • 54
    • 0029398395 scopus 로고
    • Pharmacological and clinical studies of ephedrine and other thermogenic agonists
    • Astrup, A., Breum, L., and Toubro, S. (1995) Pharmacological and clinical studies of ephedrine and other thermogenic agonists. Obes. Res. 3, 537S-540S
    • (1995) Obes. Res. , vol.3
    • Astrup, A.1    Breum, L.2    Toubro, S.3
  • 55
    • 0029400217 scopus 로고
    • β-Agonists as antiobesity, antidiabetic and nutrient partitioning agents
    • Yen, T. T. (1995) β-Agonists as antiobesity, antidiabetic and nutrient partitioning agents. Obes. Res. 3, 531S-536S
    • (1995) Obes. Res. , vol.3
    • Yen, T.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.