Cell cycle dysregulation in oral cancer

Critical Reviews in Oral Biology and Medicine

Volumn 13, Issue 1, 2002, Pages 51-61

  Todd, R ^a   Hinds, P W ^b   Munger, K ^b   Rustgi, A K ^c   Opitz, O G ^c   Suliman, Y ^c   Wong, D T ^d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Apoptosis; Cell cycle; Oral cancer; Proliferation; Senescence

Indexed keywords

CISPLATIN; CYCLIN D1; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; FLUOROURACIL; ONYX 015; PROTEIN P16; PROTEIN P21; PROTEIN P27; PROTEIN P53; REGULATOR PROTEIN; RETINOBLASTOMA PROTEIN;

APOPTOSIS; CARCINOGENESIS; CELL AGING; CELL CYCLE; CLINICAL TRIAL; DNA DAMAGE; HUMAN; KERATINOCYTE; MOUTH CANCER; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0036074339     PISSN: 10454411     EISSN: None     Source Type: Journal    
DOI: 10.1177/154411130201300106     Document Type: Review

References (132)

1. MDM2/p53 co-expression in oral premalignant and malignant lesions: Potential prognostic implications
2. Inactivation patterns of the p16 (INK4a) gene in oral squamous cell carcinoma cell lines
3. Cyclin D1 is a nuclear protein required for cell cycle progression in G1
4. A mutant adenovirus which selectively replicates in tumor cells with nonfunctional p53
5. Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene
6. INK4A expression predict reduced survival in carcinoma of the anterior tongue
7. Gene therapy for head and neck cancer
8. Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck
9. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck
10. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
11. Cyclin D1 expression is predictive of occult metastases in head and neck cancer patients with clinically negative cervical lymph nodes
12. p21 (WAF1/Cip1) retards the growth of human squamous cell carcinomas in vivo
13. p53 and cyclin D1 staining patterns of malignant and premalignant oral lesions in age-dependent populations
14. Expression of p16 and CDK4 in oral premalignant lesions and oral squamous cell carcinomas: A semi-quantitative immunohistochemical study
15. Mutations in the long control region of human papillomavirus DNA in oral cancer cells, and their functional consequences
16. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
17. Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers
18. Differential DNA methylation of the p16 INK4A/CDKN2A promoter in human oral cancer cells and normal human oral keratinocytes
19. Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer
20. p16 mutation frequency and clinical correlation in head and neck cancer
21. Influence of p53 and bcl-2 on proliferative activity and treatment outcome in head and neck cancer patients
22. Differential regulation of E2F transactivation by cyclin/cdk2 complexes
23. Specific regulation of E2F family members by cyclin-dependent kinases
24. Adenovirus E1A targets key regulators of cell proliferation
25. WAF1, a potential mediator of p53 tumor suppression
26. Expression of p16, Rb, and cyclin D1 gene products in oral and laryngeal squamous carcinoma: Biological and clinical implications
27. Induction of apoptosis in fibroblasts by c-myc
28. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
29. Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck
30. Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck
31. Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma
32. A phase I study of ONYX-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
33. The complexity of p53 modulation: Emerging patterns from divergent signals
34. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers
35. Cell cycle regulatory proteins - An overview with relevance to oral cancer
36. Tumor necrosis factor induces genes involved in inflammation, cellular and tissue repair, and metabolism in murine fibroblasts
37. Cdk6 can shorten G1 phase dependent on the N-terminal INK4 interaction domain
38. p53 dependent cell death/apoptosis is required for a productive adenovirus infection
39. The p21 CDK-interacting protein cip1 is a potent inhibitor of G1 cyclin-dependent kinases
40. Mdm2 promotes the rapid degradation of p53
41. Telomerase activity in head and neck tumors after wild-type p53, p21, p16, and E2F-1 genes by means of recombinant adenovirus
42. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
43. Function of a human cyclin gene as an oncogene
44. Proliferative and apoptotic responses in cancers with special reference to oral cancers
45. Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
46. A controlled trial of intratumoral ONYX-015, a selectively replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
47. HPV-16, tobacco-specific N nitrosamine, and N-methyl-N′-nitro-N-nitrosoguanidine in oral carcinogenesis
48. A phase II trial of ONYX-015, a selectively replicating adenovirus, in combination with cisplatin and fluorouracil in patients with recurrent head and neck cancer
49. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S-phase checkpoint
50. Expression of p53 and p21CIP1/WAF1 proteins in oral epithelial dysplasias and squamous cell carcinomas
51. Reduced expression of p27 (Kip1) correlates with an early stage of cancer invasion in oral squamous cell carcinoma
52. p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells
53. Differential expression of key cell cycle genes (p16/cyclin D1/pRb) in head and neck squamous carcinomas
54. p53, guardian of the genome
55. Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase
56. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
57. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence: Relationship of dysfunction to immortality and neoplasia
58. Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice
59. Image analysis of p53 and cyclin D1 expression in premalignant lesions of the oral mucosa
60. Control of the cell cycle and apoptosis
61. A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice
62. Detection of human papillomavirus DNA in biopsies of human oral tissue
63. DOC-1, a growth suppressor, associates with DNA polymerase α/primase
64. Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma
65. High prevalence of p16 genetic alterations in head and neck tumours
66. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
67. A novel cyclin encoded by a bcl1-linked candidate oncogene
68. A transgenic mouse model with cyclin D1 overexpression results in cell cycle, epidermal growth factor receptor and p53 abnormalities
69. The targeting of the cyclin D1 oncogene by an Epstein-Barr virus promoter in transgenic mice causes dysplasia in the tongue, esophagus and forestomach
70. Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4
71. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
72. Expression of p21/waf1 in oral squamous cell carcinomas - Correlation with p553 and mdm2 and cellular proliferation index
73. Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx
74. Cyclin D1 amplification is independent of p16 inactivation in head and neck squamous cell carcinoma
75. pRb and p16 protein alterations in human oral tumorigenesis
76. Frequent inactivation of p16INK4a in oral premalignant lesions
77. Immortalization of normal human oral keratinocytes with type 16 human papillomavirus
78. New insights into p53 stabilisation in oral squamous cell carcinoma
79. Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis
80. Absence of retinoblastoma gene product in human primary oral cavity carcinomas
81. Doing the right thing: Feedback control and p53
82. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
83. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
84. INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
85. p53, p21, Rb, and MDM2 proteins in tongue carcinoma from patients <35 versus >75 years
86. Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia
87. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
88. p16INK4a adenovirus-mediated gene therapy for human head and neck squamous cell cancer
89. Cyclin D1 overexpression in mouse epidermis increases cyclin-dependent kinase activity and cell proliferation in vivo but does not affect skin tumor development
90. ras activity and cyclin D1 expression: An essential mechanism of mouse skin tumor development
91. Immunohistochemical analysis of cell cycle-associated proteins p16, pRb, p53, p27 and Ki-67 in oral cancer and pre-cancer with special reference to verrucous carcinomas
92. The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma
93. Gene promoter hypermethylation in tumors and serum of head and neck cancer patients
94. Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines
95. Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas
96. Cell cycle proteins and the development of oral squamous cell carcinoma
97. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
98. Mammalian G1 cyclins
99. D-type cylins
100. G1 phase progression: Cycling on cue
101. The Pezcoller lecture: Cancer cell cycles revisited
102. Genome-wide analysis of oral cancer - Early results from the Cancer Genome Anatomy Project
103. Oncogenic transformation of HPV-immortalized human oral keratinocytes is associated with the genetic instability of cells
104. DOC-1 is a novel CDK2-associated protein
105. DOC-1 expression is a negative prognostic indicator in head and neck/oral cancer
106. Cyclin D1 provides a link between development and oncogenesis in the retina and breast
107. Early diagnosis of oral cancer
108. Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice
109. The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissues
110. Expression of p53 and p1 proteins in oral squamous cell carcinoma: Correlation with lymph node metastasis and response to chemoradiotherapy
111. p53 gene status as a predictor of tumor response to induction chemotherapy of patients with locoregionally advanced squamous cell carcinomas of the head and neck
112. Elevated activity of cyclin-dependent kinase 6 in human squamous cell carcinoma lines
113. Re-expression of endogenous p16ink4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state
114. Deleted in oral cancer-1 (doc-1), a novel oral tumor suppressor gene
115. Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene doc-1
116. Molecular assays for the diagnosis of minimal residual head and neck cancer: Methods, reliability, pitfalls, and solutions
117. Expression of p21 (Waf1/Cip1) in head and neck cancer in relation to proliferation, differentiation, p53 status and cyclin expression
118. Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx
119. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
120. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
121. p53 and P-glycoprotein expression are significant prognostic markers in advanced head and neck cancer treated with chemo-radiotherapy
122. The retinoblastoma protein and cell cycle control
123. An information-intensive approach to the molecular pharmacology of cancer
124. DNA studies underestimate the major role of CDKN2A inactivation in oral and oropharyngeal squamous cell carcinomas
125. Human papillomaviruses and oral neoplasia
126. Human papillomavirus DNA in biopsies of oral tissues
127. Abnormalities and the implication of retinoblastoma locus and its protein product in head and neck cancers
128. WAF1/CIP1 is unrelated to p53 tumor suppressor gene status in oral squamous cell carcinoma
129. p53 gene mutations in oropharyngeal carcinomas: A comparison of solitary and multiple primary tumours and lymph-node metastases
130. ARF_INK4a locus deletion impairs both the Rb and p3 tumor suppressor pathways
131. Papillomavirus infections - A major cause of human cancers