메뉴 건너뛰기




Volumn 24, Issue 1, 1999, Pages 1-6

ras activity and cyclin D1 expression: An essential mechanism of mouse skin tumor development

Author keywords

Cell cycle; Cyclin D1; Ras; Skin tumors

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; RETINOBLASTOMA PROTEIN;

EID: 0032909693     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199901)24:1<1::AID-MC1>3.0.CO;2-E     Document Type: Review
Times cited : (56)

References (61)
  • 2
    • 0029680611 scopus 로고    scopus 로고
    • Signalling pathways: Lack of all cascades
    • Cahill MA. Signalling pathways: Lack of all cascades. Curr Biol 1996;6:16-19.
    • (1996) Curr Biol , vol.6 , pp. 16-19
    • Cahill, M.A.1
  • 3
    • 0027732538 scopus 로고
    • Proteins regulating ras and its relatives
    • Boguski M, McCormick F. Proteins regulating ras and its relatives. Nature 1993;366:648-650.
    • (1993) Nature , vol.366 , pp. 648-650
    • Boguski, M.1    McCormick, F.2
  • 4
    • 0031043776 scopus 로고    scopus 로고
    • Signal transduction from multiple Ras effectors
    • Katz ME, McCormick F. Signal transduction from multiple Ras effectors. Curr Opin Genet 1997;7:75-79.
    • (1997) Curr Opin Genet , vol.7 , pp. 75-79
    • Katz, M.E.1    McCormick, F.2
  • 5
    • 0028872649 scopus 로고
    • Specificity of receptor tyrosine kinase signalling: Transient versus sustained extracellular signal-regulated kinase activation
    • Marshall CJ. Specificity of receptor tyrosine kinase signalling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 1995;80:179-185.
    • (1995) Cell , vol.80 , pp. 179-185
    • Marshall, C.J.1
  • 6
    • 0026910856 scopus 로고    scopus 로고
    • Ras activation in experimental carcinogenesis
    • 199
    • Mangues R, Pellicer A. ras activation in experimental carcinogenesis. Semin Cancer Biol 199;3:229-239.
    • Semin Cancer Biol , vol.3 , pp. 229-239
    • Mangues, R.1    Pellicer, A.2
  • 7
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee AB. G1 events and regulation of cell proliferation. Science 1989;246:603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 8
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • Hunter T, Pines J. Cyclins and cancer II: Cyclin D and CDK inhibitors come of age. Cell 1994;79:573-582.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 9
    • 0028171292 scopus 로고
    • G1 phase progression: Cyclin on cue
    • Sherr CJ. G1 phase progression: Cyclin on cue. Cell 1994;79: 551-555.
    • (1994) Cell , vol.79 , pp. 551-555
    • Sherr, C.J.1
  • 10
    • 0027336491 scopus 로고
    • Mammalian G1 cyclins
    • Sherr CJ, Mammalian G1 cyclins. Cell 1993;73:1059-1065.
    • (1993) Cell , vol.73 , pp. 1059-1065
    • Sherr, C.J.1
  • 11
    • 0026649165 scopus 로고
    • Formation and activation of a cyclin E-cdk2 complex during G1 phase of the human cell cycle
    • Koff A, Giordano A, Desai D, et al. Formation and activation of a cyclin E-cdk2 complex during G1 phase of the human cell cycle. Science 1992;257:1689-1693.
    • (1992) Science , vol.257 , pp. 1689-1693
    • Koff, A.1    Giordano, A.2    Desai, D.3
  • 12
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cydin-dependent kinases
    • Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cydin-dependent kinases. Genes Dev 1995;9:1149-1163.
    • (1995) Genes Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 13
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 14
    • 0026378445 scopus 로고    scopus 로고
    • E2F transcription factor is a target for the RB protein and the cyclin A protein
    • 199
    • Nevins J, Chellappan S, Mudryj M, et al. E2F transcription factor is a target for the RB protein and the cyclin A protein. Cold Spring Harb Symp Quant Biol 199;56:157-162.
    • Cold Spring Harb Symp Quant Biol , vol.56 , pp. 157-162
    • Nevins, J.1    Chellappan, S.2    Mudryj, M.3
  • 15
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Nevins JR. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 1992;258:424-429.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 16
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ. Cancer cell cycles. Science 1996;274:1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 17
    • 0027429033 scopus 로고
    • Altered expression of the cyclin D1 and retinoblastome genes in human esophageal cancer
    • Jiang W, Zhang Y-J, Khan SM, et al. Altered expression of the cyclin D1 and retinoblastome genes in human esophageal cancer. Proc Natl Acad Sci USA 1992;90:9026-9030.
    • (1992) Proc Natl Acad Sci USA , vol.90 , pp. 9026-9030
    • Jiang, W.1    Zhang, Y.-J.2    Khan, S.M.3
  • 18
    • 0028129951 scopus 로고
    • The PRAD1/cyclin D1 oncogene product accumulate aberrantly in a subset of colorectal carcinomas
    • Bartkova J, Lukas J, Strauss M, Bartek J. The PRAD1/cyclin D1 oncogene product accumulate aberrantly in a subset of colorectal carcinomas. Int J Cancer 1994;58:568-573.
    • (1994) Int J Cancer , vol.58 , pp. 568-573
    • Bartkova, J.1    Lukas, J.2    Strauss, M.3    Bartek, J.4
  • 19
    • 0028124330 scopus 로고
    • Cyclin D1 overexpression vs. Retinoblasoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer
    • Schauer IE, Siriwardana S, Langan TA, Sclafani RA. Cyclin D1 overexpression vs. retinoblasoma inactivation: Implications for growth control evasion in non-small cell and small cell lung cancer. Proc Natl Acad Sci USA 1994;91:7828-7831.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7828-7831
    • Schauer, I.E.1    Siriwardana, S.2    Langan, T.A.3    Sclafani, R.A.4
  • 20
    • 0028988245 scopus 로고
    • Aberrations of p16Ink4 and retinoblastoma tumor-suppressor genes occur in distinct subsets of human cancer cell lines
    • Aagaard L, Lukas J, Bartkova J, et al. Aberrations of p16Ink4 and retinoblastoma tumor-suppressor genes occur in distinct subsets of human cancer cell lines, Int J Cancer 1995;61:115-120.
    • (1995) Int J Cancer , vol.61 , pp. 115-120
    • Aagaard, L.1    Lukas, J.2    Bartkova, J.3
  • 21
    • 0028172926 scopus 로고
    • Absence of p16Ink4 protein is restricted to a subset of lung cancer cell lines that retains wildtype RB
    • Otterson GA, Kratze RA, Coxon A, Kim YW, Kaye FJ. Absence of p16Ink4 protein is restricted to a subset of lung cancer cell lines that retains wildtype RB. Oncogene 1994;9:3375-3378.
    • (1994) Oncogene , vol.9 , pp. 3375-3378
    • Otterson, G.A.1    Kratze, R.A.2    Coxon, A.3    Kim, Y.W.4    Kaye, F.J.5
  • 22
    • 0028961521 scopus 로고
    • Reciprocal Rb inactivation and p16Ink4 expression in primary lung cancers and cell lines
    • Shapiro GI, Edwards CD, Kobzik L, et al. Reciprocal Rb inactivation and p16Ink4 expression in primary lung cancers and cell lines. Cancer Res 1995;55:505-509.
    • (1995) Cancer Res , vol.55 , pp. 505-509
    • Shapiro, G.I.1    Edwards, C.D.2    Kobzik, L.3
  • 23
    • 0028970951 scopus 로고
    • Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control
    • Lukas J, Aagaard L, Strauss M, Bartek J. Oncogenic aberrations of p16INK4/CDKN2 and cyclin D1 cooperate to deregulate G1 control. Cancer Res 1995;55:4818-4823.
    • (1995) Cancer Res , vol.55 , pp. 4818-4823
    • Lukas, J.1    Aagaard, L.2    Strauss, M.3    Bartek, J.4
  • 24
    • 0029976462 scopus 로고    scopus 로고
    • Increased expression of cyclin D1 and the RB tumor suppressor gene in c-K-ras transformed rat enterocytes
    • Arber N, Sutler T, Miyake M, et al. Increased expression of cyclin D1 and the RB tumor suppressor gene in c-K-ras transformed rat enterocytes. Oncogene 1996;12:1903-1908.
    • (1996) Oncogene , vol.12 , pp. 1903-1908
    • Arber, N.1    Sutler, T.2    Miyake, M.3
  • 25
    • 0028152992 scopus 로고
    • Induction of cyclin D1 overexpression by activated ras
    • Filmus J, Robles AI, Shi W, et al. Induction of cyclin D1 overexpression by activated ras. Oncogene 1994;9:3627-3633.
    • (1994) Oncogene , vol.9 , pp. 3627-3633
    • Filmus, J.1    Robles, A.I.2    Shi, W.3
  • 26
    • 0029017456 scopus 로고
    • Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH3T3 cells
    • Liu JJ, Chao JR, Jiang MC, et al. Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH3T3 cells. Mol Cell Biol 1995;15:3654-3663.
    • (1995) Mol Cell Biol , vol.15 , pp. 3654-3663
    • Liu, J.J.1    Chao, J.R.2    Jiang, M.C.3
  • 27
    • 0028970609 scopus 로고
    • Transforming p21 ras mutants and c-Ets-2 activated the cyclin D1 promoter through distinguishable regions
    • Albanese C, Johnson J, Watanabe G, et al. Transforming p21 ras mutants and c-Ets-2 activated the cyclin D1 promoter through distinguishable regions. J Biol Chem 1995;270:23589-23597.
    • (1995) J Biol Chem , vol.270 , pp. 23589-23597
    • Albanese, C.1    Johnson, J.2    Watanabe, G.3
  • 28
    • 0031039113 scopus 로고    scopus 로고
    • Transformation by ras modifies AP1 composition and activity
    • Mechta F, Lalleman D, Pfarr CM, Yaniv M. Transformation by ras modifies AP1 composition and activity. Oncogene 1997;14: 837-847.
    • (1997) Oncogene , vol.14 , pp. 837-847
    • Mechta, F.1    Lalleman, D.2    Pfarr, C.M.3    Yaniv, M.4
  • 29
    • 0031453368 scopus 로고    scopus 로고
    • Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27Kip1
    • Weber JD, Hu W, Jefcoat SC, Raben DM, Baldassare JJ. Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27Kip1. J Biol Chem 1997;272:32966-32971.
    • (1997) J Biol Chem , vol.272 , pp. 32966-32971
    • Weber, J.D.1    Hu, W.2    Jefcoat, S.C.3    Raben, D.M.4    Baldassare, J.J.5
  • 30
    • 0030989155 scopus 로고    scopus 로고
    • Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the cdk inhibitor p27Kip1
    • Aktas H, Cai H, Cooper G. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the cdk inhibitor p27Kip1. Mol Cell Biol 1997;17:3850-3857.
    • (1997) Mol Cell Biol , vol.17 , pp. 3850-3857
    • Aktas, H.1    Cai, H.2    Cooper, G.3
  • 31
    • 0030740210 scopus 로고    scopus 로고
    • Ras activity in G1 phase required for p27 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH3T3 fibroblasts
    • Takuwa N, Takuwa Y. Ras activity in G1 phase required for p27 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH3T3 fibroblasts. Mol Cell Biol 1997;17:5348-5358.
    • (1997) Mol Cell Biol , vol.17 , pp. 5348-5358
    • Takuwa, N.1    Takuwa, Y.2
  • 32
    • 0028931152 scopus 로고
    • Inhibition of ras-induced proliferation and cellular transformation by p16INK4
    • Serrano M, Gomes-Lahoz E, DePinho RA, Beach D, Bar-Sagi D. Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science 1995;267:249-252.
    • (1995) Science , vol.267 , pp. 249-252
    • Serrano, M.1    Gomes-Lahoz, E.2    DePinho, R.A.3    Beach, D.4    Bar-Sagi, D.5
  • 33
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 34
    • 0030941460 scopus 로고    scopus 로고
    • Ras signalling linked to cell-cycle machinery by the retinoblastome protein
    • Pepper DS, Upton TM, Ladha MH, et al. Ras signalling linked to cell-cycle machinery by the retinoblastome protein. Nature 1997;386:177-181.
    • (1997) Nature , vol.386 , pp. 177-181
    • Pepper, D.S.1    Upton, T.M.2    Ladha, M.H.3
  • 35
    • 0029658129 scopus 로고    scopus 로고
    • p21ras-mediated decrease of the retinoblastoma protein in fibroblasts occurs through growth factor-dependent mechanism
    • Kivinen L, Tiihonen, E, Haapajarvi T, Laiho M. p21ras-mediated decrease of the retinoblastoma protein in fibroblasts occurs through growth factor-dependent mechanism. Cell Growth Differ 1996;7:1705-1712.
    • (1996) Cell Growth Differ , vol.7 , pp. 1705-1712
    • Kivinen, L.1    Tiihonen, E.2    Haapajarvi, T.3    Laiho, M.4
  • 36
    • 0030996978 scopus 로고    scopus 로고
    • K-ras modulates the cell cycle via both positive and negative regulatory pathways
    • Fan J, Bertino JR. K-ras modulates the cell cycle via both positive and negative regulatory pathways. Oncogene 1997;14:2595-2606.
    • (1997) Oncogene , vol.14 , pp. 2595-2606
    • Fan, J.1    Bertino, J.R.2
  • 37
    • 0029951444 scopus 로고    scopus 로고
    • Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events
    • Kang J-S, Krauss RS. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events. Mol Cell Biol 1996;16:3370-3380.
    • (1996) Mol Cell Biol , vol.16 , pp. 3370-3380
    • Kang, J.-S.1    Krauss, R.S.2
  • 38
    • 0031943640 scopus 로고    scopus 로고
    • Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth
    • Yang J-J, Kang J-S, Krauss RS. Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth. Mol Cell Biol 1998;18:2586-2595.
    • (1998) Mol Cell Biol , vol.18 , pp. 2586-2595
    • Yang, J.-J.1    Kang, J.-S.2    Krauss, R.S.3
  • 39
    • 0024534718 scopus 로고
    • Cellular and molecular mechanisms involved in multistage skin carcinogenesis
    • Conti CJ, Slaga TJ, Klein-Szanto AJ, editors. New York: Raven Press
    • Slaga TJ. Cellular and molecular mechanisms involved in multistage skin carcinogenesis. In: Conti CJ, Slaga TJ, Klein-Szanto AJ, editors. Carcinogenesis. A comprehensive survey. New York: Raven Press. 1989; p1-18.
    • (1989) Carcinogenesis. A Comprehensive Survey , pp. 1-18
    • Slaga, T.J.1
  • 40
    • 0020586334 scopus 로고
    • Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene
    • Balmain A, Pragnell I. Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 1983;303:72-74.
    • (1983) Nature , vol.303 , pp. 72-74
    • Balmain, A.1    Pragnell, I.2
  • 41
    • 0011493380 scopus 로고
    • Mutagenesisof the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons
    • Bizub D, Wood A, Skalka A. Mutagenesisof the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc Natl Acad Sci USA 1986;83:6048-6052.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 6048-6052
    • Bizub, D.1    Wood, A.2    Skalka, A.3
  • 42
    • 0022977903 scopus 로고
    • An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue
    • Roop D, Lowy D, Tambourin P, et al. An activated Harvey ras oncogene produces benign tumours on mouse epidermal tissue. Nature 1986;323:822-824.
    • (1986) Nature , vol.323 , pp. 822-824
    • Roop, D.1    Lowy, D.2    Tambourin, P.3
  • 43
    • 0022527161 scopus 로고
    • Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis
    • Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 1986;322:78-80.
    • (1986) Nature , vol.322 , pp. 78-80
    • Quintanilla, M.1    Brown, K.2    Ramsden, M.3    Balmain, A.4
  • 44
    • 0006865591 scopus 로고
    • A comprehensive survey
    • Slaga TJ, Sivak A, Boutwell RR, editors New York: Raven Press
    • Burns FJ, Vanderlaan M, Snyder E, Albert RE. A comprehensive survey. In: Slaga TJ, Sivak A, Boutwell RR, editors. Carcinogenesis. New York: Raven Press; 1978. p. 91-96.
    • (1978) Carcinogenesis , pp. 91-96
    • Burns, F.J.1    Vanderlaan, M.2    Snyder, E.3    Albert, R.E.4
  • 45
    • 0027359975 scopus 로고
    • Cooperation between v-fos and v-Ha-ras induces autonomous papillomas in transgenic epidermis but not malignant conversion
    • Greenhalgh D, Quintanilla M, Orengo C, et al. Cooperation between v-fos and v-Ha-ras induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Res 1993;53:5071-5075.
    • (1993) Cancer Res , vol.53 , pp. 5071-5075
    • Greenhalgh, D.1    Quintanilla, M.2    Orengo, C.3
  • 46
    • 0027516110 scopus 로고
    • Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene
    • Greenhalgh D, Rothnagel J, Quintanilla M, et al. Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene. Mol Carcinog 1993;7:99-110.
    • (1993) Mol Carcinog , vol.7 , pp. 99-110
    • Greenhalgh, D.1    Rothnagel, J.2    Quintanilla, M.3
  • 47
    • 0025647881 scopus 로고
    • v.-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid
    • Leder A, Kuo A, Cardiff R, Sinn E, Leder P. v.-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid. Proc Natl Acad Sci USA 1990;87:9178-9182.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9178-9182
    • Leder, A.1    Kuo, A.2    Cardiff, R.3    Sinn, E.4    Leder, P.5
  • 48
    • 0027237453 scopus 로고
    • Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene
    • Spalding J, Momma J, Elwell M, Tennant R. Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene. Carcinogenesis 1993;14:1335-1341.
    • (1993) Carcinogenesis , vol.14 , pp. 1335-1341
    • Spalding, J.1    Momma, J.2    Elwell, M.3    Tennant, R.4
  • 50
    • 0028940248 scopus 로고
    • Early overexpression of cyclin D1 protein in mouse skin carcinogenesis
    • Robles AI, Conti CJ. Early overexpression of cyclin D1 protein in mouse skin carcinogenesis. Carcinogenesis 1995;16:781-786.
    • (1995) Carcinogenesis , vol.16 , pp. 781-786
    • Robles, A.I.1    Conti, C.J.2
  • 51
    • 0032578864 scopus 로고    scopus 로고
    • Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin
    • Rodriguez-Puebla ML, LaCava M, Gimenez-Conti IB, Johnson DG, Conti CJ. Deregulated expression of cell-cycle proteins during premalignant progression in SENCAR mouse skin. Oncogene 1998;17:2251-2258.
    • (1998) Oncogene , vol.17 , pp. 2251-2258
    • Rodriguez-Puebla, M.L.1    LaCava, M.2    Gimenez-Conti, I.B.3    Johnson, D.G.4    Conti, C.J.5
  • 52
    • 0031964722 scopus 로고    scopus 로고
    • Synchronized proliferation induced by 12-O-tetradecanoylphorbol-13-acetate treatment of mouse skin: An in vivo model for cell cycle regulation
    • Rodriguez-Puebla ML, Robles AI, Johnson DG, LaCava M, Conti CJ. Synchronized proliferation induced by 12-O-tetradecanoylphorbol-13-acetate treatment of mouse skin: An in vivo model for cell cycle regulation. Cell Growth Differ 1998;9:31-39.
    • (1998) Cell Growth Differ , vol.9 , pp. 31-39
    • Rodriguez-Puebla, M.L.1    Robles, A.I.2    Johnson, D.G.3    LaCava, M.4    Conti, C.J.5
  • 53
    • 0032529165 scopus 로고    scopus 로고
    • Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo
    • Robles AI, Rodriguez-Puebla ML, Glick AB, et al. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev 1998;12:2469-2474.
    • (1998) Genes Dev , vol.12 , pp. 2469-2474
    • Robles, A.I.1    Rodriguez-Puebla, M.L.2    Glick, A.B.3
  • 54
    • 0029111934 scopus 로고
    • Cyclin D1 provides a link between development and oncogenesis in the retina and breast
    • Sicinski P, Donaher JL, Parker SB, et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 1995;82:621-630.
    • (1995) Cell , vol.82 , pp. 621-630
    • Sicinski, P.1    Donaher, J.L.2    Parker, S.B.3
  • 55
    • 0030762433 scopus 로고    scopus 로고
    • A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of ras intestinal epithelial cells
    • Gangarosa LM, Sizemore N, Graves-Deal R, et al. A raf-independent epidermal growth factor receptor autocrine loop is necessary for Ras transformation of ras intestinal epithelial cells. J Biol Chem 1997;272:18926-18931.
    • (1997) J Biol Chem , vol.272 , pp. 18926-18931
    • Gangarosa, L.M.1    Sizemore, N.2    Graves-Deal, R.3
  • 56
    • 0029959434 scopus 로고    scopus 로고
    • Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells
    • Oldham SM, Clark GJ, Gangarosa LM, Coffey RJ, Der CJ. Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells. Proc Natl Acad Sci USA 1996;93:6924-6928.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6924-6928
    • Oldham, S.M.1    Clark, G.J.2    Gangarosa, L.M.3    Coffey, R.J.4    Der, C.J.5
  • 57
    • 0030755457 scopus 로고    scopus 로고
    • Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-Ha-ras oncogene but does not block in vitro keratinocyte responses to oncogenic ras
    • Dlugosz AA, Hansen L, Cheng C, et al. Targeted disruption of the epidermal growth factor receptor impairs growth of squamous papillomas expressing the v-Ha-ras oncogene but does not block in vitro keratinocyte responses to oncogenic ras. Cancer Res 1997;57:3180-3188.
    • (1997) Cancer Res , vol.57 , pp. 3180-3188
    • Dlugosz, A.A.1    Hansen, L.2    Cheng, C.3
  • 58
    • 0028889751 scopus 로고
    • Mice lacking cyclin D1 are small and show defects in eye and mammary gland development
    • Fantl V, Stamp G, Andrews A, Rosewell I, Dickson C. Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev 1995;9:2364-2372.
    • (1995) Genes Dev , vol.9 , pp. 2364-2372
    • Fantl, V.1    Stamp, G.2    Andrews, A.3    Rosewell, I.4    Dickson, C.5
  • 59
    • 0029821233 scopus 로고    scopus 로고
    • Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia
    • Robles AI, Larcher F, Whalin RB, et al. Expression of cyclin D1 in epithelial tissues of transgenic mice results in epidermal hyperproliferation and severe thymic hyperplasia. Proc Natl Acad Sci USA 1996;93:7634-7638.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7634-7638
    • Robles, A.I.1    Larcher, F.2    Whalin, R.B.3
  • 60
    • 0032510342 scopus 로고    scopus 로고
    • Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development
    • Pierce AM, Fischer S, Conti CJ, Johnson DG. Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development. Oncogene 1998;16:1267-1276.
    • (1998) Oncogene , vol.16 , pp. 1267-1276
    • Pierce, A.M.1    Fischer, S.2    Conti, C.J.3    Johnson, D.G.4
  • 61
    • 0032555270 scopus 로고    scopus 로고
    • Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53
    • Pierce AM, Gimenez-Conti IB, Schneider-Broussard R, et al. Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53. Proc Natl Acad Sci USA 1998;95:8858-8863.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8858-8863
    • Pierce, A.M.1    Gimenez-Conti, I.B.2    Schneider-Broussard, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.