Enhanced activation-induced cell death as a mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity in peripheral T cells

Toxicology

Volumn 165, Issue 1, 2001, Pages 51-63

  Camacho, Iris A ^a   Hassuneh, Mona R ^a   Nagarkatti, Mitzi ^a   Nagarkatti, Prakash S ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AICD; Apoptosis; Fas; Immunotoxicity; T cell activation; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CORN OIL; FAS ANTIBODY; LIGAND; MONOCLONAL ANTIBODY CD3; TISSUE CULTURE MEDIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; FEMALE; IMMUNOTOXICITY; LIGAND BINDING; LYMPH NODE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ANTIGENS, CD95; APOPTOSIS; CELL DEATH; CELL DIVISION; ENVIRONMENTAL POLLUTANTS; FEMALE; IMMUNITY, CELLULAR; IN SITU NICK-END LABELING; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES; TETRACHLORODIBENZODIOXIN; UP-REGULATION;

ZEA MAYS;

EID: 0035855307     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00391-2     Document Type: Article

References (41)

1. Effect of in vivo administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on DNA-binding activities of nuclear transcription factors in liver of guinea pigs
2. Immunotoxic effects of prolonged dietary exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin
3. Regulation of CD95 ligand expression: A key element in immune regulation?
4. Heart as a target organ in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity: Decreased beta-adrenergic responsiveness and evidence of increased intracellular calcium
5. Dioxin induces transforming growth factor-alpha in human keratinocytes
6. Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus
7. Immune cell functions in industrial workers after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Dissociation of antigen-specific T-cell responses in cultures of diluted whole blood and of isolated peripheral blood mononuclear cells
8. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell- mediated immunity in Sprague-Dawley rats
9. Animal models of human response to dioxins
10. Immune functions of tumor necrosis factor. I. Tumor necrosis factor induces apoptosis of mouse thymocytes and can also stimulate or inhibit IL-6-induced proliferation depending on the concentration of mitogenic costimulation
11. Immunosuppression without liver induction by subchronic exposure to 2,7-dichlorodibenzo-p-dioxin in adult female B6C3F1 mice
12. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: Possible mechanisms
13. A review of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced changes in immunocompetence: 1991 Update
14. Fas (CD95)/FasL interactions required programmed cell death after T-cell activation
15. Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes
16. Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo
17. Characterization of phenotypic alterations induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin on thymocytes in vivo and its effect on apoptosis
18. Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity: Increased resistance of thymocytes from Fas-deficient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicity
19. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1
20. Immunological effects of chlorinated dibenzo-p-dioxins
21. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin
22. Identification of a monoclonal antibody specific for a murine T3 polypeptide
23. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) inhibits the activation of antigen-specific T-cells in mice
24. 2+- mediated endonuclease activation
25. Fas ligand-induced apoptosis
26. Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction
27. Chlorinated dibenzo-p-dioxins and dibenzofurans and the human immune system. 2. In vitro proliferation of lymphocytes from workers with quantified moderately-increased body burdens
28. Anti-CD3-induced T-cell activation in vivo - I. Flow cytometric analysis of dose-responsive, time-dependent, and cyclosporin A-sensitive parameters of CD4 + and CD8 + cells from the draining lymph nodes of C57Bl/6 mice
29. Anti-CD3-induced T-cell activation-II. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
30. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity
31. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on anti-CD3-induced changes in T-cell subsets and cytokine production
32. Differential induction of apoptosis in activated and resting T-cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its repercussion on T-cell responsiveness
33. Role of Fas apoptosis and MHC genes in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity of T-cells
34. Phagocyte recognition of cells undergoing apoptosis
35. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
36. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on splenic lymphocyte transformation in mice after single and repeated exposures
37. Relationship between Ah receptor-mediated polychlorinated biphenyl (PCB)-induced humoral immunosuppression and thymic atrophy
38. Targets for dioxin: Genes for plasminogen activator inhibitor-2 and interleukin-1 beta
39. Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells
40. Mechanistic aspects of dioxin action
41. Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs