Tetrahydrocannabinol-induced apoptosis of cultured cortical neurones is associated with cytochrome c release and caspase-3 activation

Neuropharmacology

Volumn 40, Issue 5, 2001, Pages 702-709

  Campbell, Veronica A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Apoptosis; Caspase 3; Cortical neurones; Cytochrome c; Pertussis toxin; Tetrahydrocannabinol

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CASPASE 3; CYSTEINE PROTEINASE; CYTOCHROME C; GUANINE NUCLEOTIDE BINDING PROTEIN; PERTUSSIS TOXIN; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL DEATH; CELL DEGENERATION; CELL MEMBRANE; CELL STRUCTURE; CONTROLLED STUDY; CYTOSOL; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME ACTIVATION; MITOCHONDRION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 1; CASPASE 3; CASPASES; CEREBRAL CORTEX; CYTOCHROME C GROUP; ENZYME ACTIVATION; GTP-BINDING PROTEINS; IN SITU NICK-END LABELING; KINETICS; MALE; MITOCHONDRIA; NERVE DEGENERATION; NEURONS; PERTUSSIS TOXIN; RATS; RATS, WISTAR; TETRAHYDROCANNABINOL; VIRULENCE FACTORS, BORDETELLA;

EID: 0035049233     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00210-0     Document Type: Article

References (36)

1. Localization of mRNA expression and activation of signal transduction mechanisms for cannabinoid receptor in rat brain during fetal development
2. Effects of chronic marijuana use on human cognition
3. Cannabinoid receptor CB1 activates the Na/H exchanger NHE-1 isoform via Gi-mediated mitogen-activated protein kinase signalling transduction pathways
4. 9-tetrahydrocannabinol
5. Cannabinoids protect cells from oxidative cell death: A receptor-independent mechanism
6. Marijuana effect and delta-9-tetrahydrocannibinol plasma level
7. Role of cyclic AMP in the actions of cannabinoid receptors
8. Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
9. A neuronal C5a receptor and its associated apoptotic signal transduction pathway
10. Marijuana use by pregnant women: Neurobehavioral effects on neonates
11. 36- and 48-month neurobehavioral follow-up of children pre-exposed to marijuana, cigarettes and alcohol
12. Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation
13. Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR141716A
14. p38 MAP kinase mediates bax translocation in nitric-oxide-induced apoptosis in neurones
15. Neuroprotective antioxidants from marijuana
16. Redox regulation of the caspases during apoptosis
17. Reverse pharmacology applied to the cannabinoid receptor
18. Pharmacology of cannabinoid receptors
19. Influence of flupirtine on a G-protein coupled inwardly rectifying potassium current in hippocampal neurones
20. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
21. Delta 9-tetrahydrocannabinol increases prefrontal cortical catecholaminergic utilization and impairs spatial working memory in the rat: Blockade of dopaminergic effects with HA966
22. Repeated exposure to delta-9-tetrahydrocannibinol reduces prefrontal cortical dopamine metabolism in the rat
23. Regulators of cell death
24. Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55, 212-2
25. The effect of delta-9-tetrahydrocannabinol on forebrain ischemia in rat
26. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
27. Marijuana intoxication and brain activation in marijuana smokers
28. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
29. Apoptosis and necrosis in toxicology; A continuum or distinct modes of cell death?
30. Opiod and cannabinoid receptors
31. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
32. The CB1 cannabinoid receptor is coupled to activation of C-jun N-terminal kinase
33. 9-tetrahydrocannabinol induces apoptosis in C6 glioma cells
34. Ras-dependent apoptosis correlates with persistent activation of stress-activated protein kinases and induction of isoforms of Bcl
35. Lipopolysaccharide inhibits long-term potentiation in the rat dendate gyrus by activating caspase-1
36. 9-tetrahydrocannabinol induces apoptosis in macrophages and lymphocytes: Involvement of Bcl-2 and caspase-1