Inhibition of LPS-induced activation of alveolar macrophages by high concentrations of LPS-binding protein

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 553-560

  Hamann, Lutz ^a,b   Stamme, Cordula ^d,e   Ulmer, Artur J ^a   Schumann, Ralf R ^b  

^a Leibniz Centers for Medicine and Biosciences   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

^d UNIVERSITY OF LÜBECK   (Germany)

^e NONE

Author keywords

Alveolar macrophages; Inflammation; Innate immunity; LPS uptake; LPS induced signaling; Lung epithelial

Indexed keywords

LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ACUTE-PHASE PROTEINS; ANIMALS; ANTIGENS, CD14; CARRIER PROTEINS; CELL LINE; ENDOCYTOSIS; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, ALVEOLAR; MALE; MEMBRANE GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0036069196     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00710-6     Document Type: Article

References (40)

1. Biochemistry of endotoxins
2. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
3. Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification
4. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
5. Structure and function of lipopolysaccharide binding protein
6. Catalytic properties of lipopolysaccharide (LPS) binding protein. Transfer of LPS to soluble CD14
7. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
8. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation
9. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
10. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact
11. Lipopolysaccharide-binding protein is required to combat a murine Gram-negative bacterial infection
12. Cytokines in severe infections: From pathophysiology to clinical applications
13. Binding internalization, and deacylation of bacterial lipopolysaccharide by human neutrophils
14. CD14-dependent internalization of bacterial lipopolysaccharide (LPS) is strongly influenced by LPS aggregation but not by cellular responses to LPS
15. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS
16. The acute phase response
17. Lipopolysaccharide toxicity-regulating proteins in bacteremia
18. LPS-binding protein protects mice from septic shock caused by LPS or Gram-negative bacteria
19. High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes
20. Binding of lipopolysaccharide (LPS) to CHO cells does not correlate with LPS-induced NF-kappaB activation
21. Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells: Implications for local defense to bacterial endotoxins
22. Relationship between soluble CD14, lipopolysaccharide binding protein, and the alveolar inflammatory response in patients with acute respiratory distress syndrome
23. Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs
24. Use of synthetic antigens to determine the epitope specificities of monoclonal antibodies against the 3-deoxy-D-manno-octulosonate region of bacterial lipopolysaccharide
25. The internalization time course of a given lipopolysaccharide chemotype does not correspond to its activation kinetics in monocytes
26. Analysis of single and double-stained alveolar macrophages by flow cytometry
27. Immunological functions of the pulmonary epithelium
28. Pulmonary LPS-binding protein (LBP) upregulation following LPS-mediated injury
29. Surfactant protein A enhances the binding and deacylation of E. coli LPS by alveolar macrophages
30. Critical role of lipopolysaccharide-binding protein and CD14 in immune responses against Gram-negative bacteria
31. Monoclonal antibodies to murine lipopolysaccharide (LPS)-binding protein (LBP) protect mice from lethal endotoxemia by blocking either the binding of LPS to LBP or the presentation of LPS/LBP complexes to CD14
32. Mode of action of anti-lipopolysaccharide-binding protein antibodies for prevention of endotoxemic shock in mice
33. The significance of high-density lipoproteins (HDL) in the clearance of intravenously administered bacterial lipopolysaccharides (LPS) in mice
34. Synthesis and surface expression of CD14 by human endothelial cells
35. Murine CD14 gene expression in vivo: Extramyeloid synthesis and regulation by lipopolysaccharide
36. Internalization of monomeric lipopolysaccharide occurs after transfer out of cell surface CD14
37. Endotoxin-specific NF-kappaB activation in pulmonary epithelial cells harboring adenovirus E1A
38. Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8
39. The potential of various lipopolysaccharides to release IL-8 and G-CSF
40. Molecular mechanisms of lipopolysaccharide induced ICAM-1 expression in A549 cells