Redox events in HTLV-1 tax-induced apoptotic T-cell death

Antioxidants and Redox Signaling

Volumn 4, Issue 3, 2002, Pages 471-477

  Chlichlia, Katerina ^a   Los, Marek ^b   Schulze Osthoff, Klaus ^b   Gazzolo, Louis ^c   Schirrmacher, Volker ^a   Khazaie, Khashayarsha ^a,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c INSERM   (France)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; TAX PROTEIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; DNA DAMAGE; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMOGENESIS; MEDIATOR RELEASE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS GENOME; CELL TRANSFORMATION; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW; T CELL LYMPHOMA; T LYMPHOCYTE;

ANTIOXIDANTS; APOPTOSIS; CELL TRANSFORMATION, NEOPLASTIC; GENE PRODUCTS, TAX; HUMAN; HUMAN T-LYMPHOTROPIC VIRUS 1; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; NF-KAPPA B; OXIDATION-REDUCTION; OXIDATIVE STRESS; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTES; HUMANS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 0036019937     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/15230860260196263     Document Type: Article

References (75)

1. Proliferative response of Tax 1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway
2. Gene expression and the thiol redox state
3. Activate NF-kappaB or die?
4. Control of apoptosis by Rel/NF-kappaB transcription factors
5. Repression of bax gene expression by the HTLV-1 Tax protein: Implications for suppression of apoptosis in virally infected cells
6. Oxidative stress as a mediator of apoptosis
7. Role of the Fas/Fas ligand pathway in apoptotic cell death induced by the human T cell lymphotropic virus type I Tax transactivator
8. Differential expression of Nur77 family members in human T-lymphotropic virus type 1-infected cells: Transactivation of the TR3/nur77 gene by Tax protein
9. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
10. Immediate effects of reversible HTLV-1 tax function: T-cell activation and apoptosis
11. ICE-proteases mediated HTLV-1 Tax-induced apoptotic T-cell death
12. Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax
13. Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax
14. Modulation of exogenous and endogenous levels of thioredoxin in human skin fibroblasts prevents DNA damaging effect of ultraviolet A radiation
15. Functions of glutathione and glutathione disulfide in immunology and immunopathology
16. Tat protein of human immunodeficiency virus type 1 represses expression of manganese superoxide dismutase in HeLa cells
17. Cytogenetic studies on the adult T-cell leukemia in Japan
18. Molecular and cellular events at the onset of the lymphoproliferative process induced by HTLV-1 (human T-cell leukaemia virus, type 1)
19. Antibodies to human T-lymphotropic virus type-1 in patients with tropical spastic paraparesis
20. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture
21. Tumours derived from HTLV-1 tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression
22. Redox regulation of apoptotic cell death in the immune system
23. Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type 1 (HTLV-1) is prevented by cytotoxic T lymphocytes
24. Oxireductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin
25. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB
26. Bcl-2 functions in an antioxidant pathway to prevent apoptosis
27. Tumorigenicity of human T-cell leukemia virus type 1-infected cell lines in severe combined immunodeficient mice and characterization of the cells proliferating in vivo
28. Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: Possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state
29. Recent advances towards understanding redox mechanisms in the activation of nuclear factor κB
30. HTLV-1 trans-activator protein, Tax, is a trans-repressor of the human β-polymerase
31. Chromosome abnormalities in adult T-cell leukemia/lymphoma: A karyotype review committee report
32. Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 Tax protein
33. HTLV-1 Tax protein sensitizes cells to apoptotic cell death induced by DNA damaging agents
34. Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway
35. Induction of apoptosis in murine clonal osteoblasts expressed by human T-cell leukemia virus type I tax by NF-kappa B and TNF-alpha
36. Inhibition of SV 40 large T antigen induced apoptosis by small Tantigen
37. Human T lymphocyte virus 1 from a leukemogenic cell line mediates in vivo and in vitro lymphocyte apoptosis
38. Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3
39. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
40. Human T cell leukemia virus-1 (HTLV-1) Tax-mediated apoptosis in activated T cells requires an enhanced intracellular pro-oxidant state
41. Induction of micronuclei by HTLV-1 Tax: A cellular assay for function
42. Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-1 Tax
43. Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bound involving cysteine 62
44. Glutathione
45. Trans-activator Tax of human T-cell leukemia virus type 1 enhances mutation frequency of the cellular genome
46. Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells
47. Expression of human inducible nitric oxide synthase gene in T-cell lines infected with human T-cell leukemia virus type-I and primary adult T-cell leukemia cells
48. Study of gene regulation by NF-kappaB and AP-1 in response to reactive oxygen intermediates
49. Redox regulation of cellular activation
50. Distinct p300-responsive mechanisms promote caspase-dependent apoptosis by human T-cell lymphotropic virus type 1 Tax protein
51. Human thioredoxin/adult T cell leukemia-derived factor activates the enhancer binding protein of human immunodeficiency virus type 1 by thiol redox control mechanism
52. HTLV-1 associated myelopathy, a new clinical entity
53. Selection forces and constraints on retroviral sequence variation
54. Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: Role of tax gene
55. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
56. Cellular transformation by human T-cell leukemia virus type I
57. NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death
58. Tax protein of human T-lymphotropic virus type I triggers DNA damage
59. Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1
60. Antioxidants selectively suppress activation of NF-kappa B by human T-cell leukemia virus type I Tax protein
61. Persistent activation of NF-kappaB by the Tax transforming protein of HTLV-1: Hijacking cellular IkappaB kinases
62. HTLV-1 Tax protein interacts with cyclin-dependent kinase inhibitor p161NK4a and counteracts its inhibitory activity to CDK4
63. Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging
64. Human papillomavirus E6 and E7: Proteins which deregulate the cell cycle
65. Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax
66. Insight into the tumor suppressor function of CBP through the viral oncoprotein tax
67. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120
68. HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state
69. Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus
70. Genes involved in T-cell receptor-mediated apoptosis of thymocytes and T-cell hybridomas
71. The human T-cell leukemia virus type 1 Tax protein induces apoptosis which is blocked by the Bcl-2 protein
72. Diseases associated with HTLV-1 virus, IL-2 receptor dysregulation and redox regulation
73. Mechanism of transcriptional activation of viral and cellular genes by oncogenic protein of HTLV-1
74. Multiple viral strategies of HTLV-1 for dysregulation of cell growth control
75. Isolation and characterization of a retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease