Insight into the tumor suppressor function of CBP through the viral oncoprotein Tax

Gene Expression

Volumn 9, Issue 1-2, 2000, Pages 29-36

  Van Orden, K ^a   Nyborg, J K ^a  

^a Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

CREB binding protein (CBP); Tax oncoprotein; Tumor suppression

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA BINDING PROTEIN; HISTONE; ONCOPROTEIN; TRANSCRIPTION FACTOR;

ACETYLATION; BLOOD DISEASE; CANCER INHIBITION; GENE EXPRESSION; HUMAN T CELL LEUKEMIA VIRUS; NONHUMAN; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; REVIEW; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

HTLV; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 0033678398     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: 10.3727/000000001783992678     Document Type: Review

References (90)

1. Abnormalities of chromosome band 8p11 in leukemia: Two clinical syndromes can be distinguished on the basis of MOZ involvement
2. Aberrant expression and function of p53 in T-cells immortalized by HTLV-I Tax 1
3. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis
4. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
5. Use of selectively trypsinized nucleosome core particles to analyze the role of the histone 'tails' in the stabilization of the nucleosome
6. The CBP co-activator is a histone acetyltransferase
7. Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro
8. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation
9. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
10. Regulation of activity of the transcription factor GATA-1 by acetylation
11. p53 Functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells
12. A case of inv(8)(p11q24) associated with acute myeloid leukemia involves the MOZ and CBP genes in a masked t(8;16)
13. Phosphorylated CREB binds specifically to the nuclear protein CBP
14. The human T-cell leukemia virus type 1 oncoprotein tax inhibits the transcriptional activity of c-Myb through competition for the CREB binding protein
15. CBP as a transcriptional coactivator of c-Myb
16. Characterization of monoclonal antibodies raised against p300: Both p300 and CBP are present in intracellular TBP complexes
17. Association of p300 and CBP with simian virus 40 large T antigen
18. Rapid quantification of HTLV-I provirus load: Detection of monoclonal proliferation of HTLV-I-infected cells among blood donors
19. Role of the histone 'tails' in the folding of oligonucleosomes depleted of histone H1
20. Functional inactivation of wild-type p53 protein correlates with loss of IL-2 dependence in HTLV-I transformed human T lymphocytes
21. Anchoring of CREB binding protein to the human T-cell leukemia virus type 1 promoter: A molecular mechanism of tax transactivation
22. Studies on histone fraction F2A1 in macro- and micronuclei of Tetrahymena pyriformis
23. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture
24. Exocrinopathy resembling Sjogren's syndrome in HTLV-1 tax transgenic mice
25. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I
26. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
27. An exposed KID-like domain in human T-cell lymphotropic virus type 1 tax is responsible for the recruitment of coactivators CBP/p300
28. Histone contributions to the structure of DNA in the nucleosome
29. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
30. Acetylation of general transcription factors by histone acetyltransferases
31. PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner
32. Disruption of nucleotide excision repair by the human T-cell leukemia virus type 1 tax protein
33. The coactivator CBP stimulates human T-cell lymphotrophic virus type I tax transactivation in vitro
34. Variation in the clinical courses of adult T-cell leukemia
35. Specific regions of contact between human T-cell leukemia virus type I tax protein and DNA identified by photocross-linking
36. Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
37. Control of cAMP-regulated enhancers by the viral transactivator tax through CREB and the co-activator CBP
38. Nuclear protein CBP is a coactivator for the transcription factor CREB
39. Differential activation of viral and cellular promoters by human T-cell lymphotropic virus-1 tax and cAMP-responsive element modulator isoforms
40. A positive role for histone acetylation in transcription factor access to nucleosomal DNA
41. The tax protein-DNA interaction is essential for HTLV-I transactivation in vitro
42. Human T-cell leukemia virus type 1 tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter
43. Crystal structure of the nucleosome core particle at 2.8 A resolution
44. The human T-cell leukemia virus-1 transcriptional activator tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove
45. Effect of histone acteylation on structure and in vitro transcription of chromatin
46. Tumors in Rubinstein-Taybi syndrome
47. Human T-cell lymphotropic/leukemia virus type 1 tax abrogates p53- induced cell cycle arrest and apoptosis through its CREB/ATF functional domain
48. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I
49. Factors associated with the mammalian RNA polymerase II holoenzyme
50. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
51. The transcriptional coactivators p300 and CBP are histone acetyltransferases
52. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
53. Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter
54. Phosphorylation of CREB at Ser-133 induces complex formation with CREB- binding protein via a direct mechanism
55. Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis
56. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
57. Defective DNA repair in cells with human T-cell leukemia/bovine leukemia viruses: Role of tax gene
58. Inhibition of p53 transactivation function by the human T-cell lymphotropic virus type 1 tax protein
59. Detection and isolation of type C retrovirus particle from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
60. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
61. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator: Coactivator interactions
62. Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I
63. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases
64. All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
65. Expression of the transcriptional activator tax protein of human T-cell leukemia virus type I increases the radiosensitivity of a mouse fibroblast cell line to ionizing radiation
66. Expression of the transcriptional activator tax protein of human T-cell leukemia virus type I increases the radiosensitivity of a mouse fibroblast cell line to ionizing radiation
67. Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates
68. The p300/CBP family: Integrating signals with transcription factors and chromatin
69. Keloids and neoplasms in the Rubinstein-Taybi syndrome
70. Studies of the putative transforming protein of the type I human T-cell leukemia virus
71. MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with fanconi anemia
72. Tax protein of HTLV-1 inhibits CBP/p300-mediated transcription by interfering with recruitment of CBP/p300 onto DNA element of E-box or p53 binding site
73. Inhibitory interaction of c-Myb and GATA-1 via transcriptional co-activator CBP
74. The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
75. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro
76. Abnormal skeletal patterning in embryos lacking a single Cbp allele: A partial similarity with Rubinstein-Taybi syndrome
77. c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300
78. Binding of p53 to the KIX domain of CREB binding protein: A potential link to human T-cell leukemia virus, type I-associated leukemogenesis
79. Binding of the human T-cell leukemia virus tax protein to the coactivator CBP interferes with CBP-mediated transcriptional control
80. Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro
81. HTLV-1-associated diseases
82. The myb genes
83. Histone modification and transcriptional competence
84. Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I tax protein
85. Molecular interactions between the coactivator CBP and the human T-cell leukemia virus tax protein
86. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A
87. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300
88. Mechanism by which the IFN-beta enhanceosome activates transcription