Subcellular pharmacokinetics and its potential for library focusing

Journal of Molecular Graphics and Modelling

Volumn 20, Issue 6, 2002, Pages 479-490

  Balaz, Stefan ^a   Lukacova, Viera ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Amphiphilicity; Disposition function; Distribution; Lipophilicity; Reactivity

Indexed keywords

ABSORPTION; ACIDITY; BIOLOGICAL MEMBRANES; CELLS; HYDROLYSIS; METABOLISM; OPTIMIZATION; PROTEINS; TOXICITY;

BIOSYSTEMS;

PHARMACOKINETICS;

PHENOL DERIVATIVE;

ACCURACY; ACIDITY; BIOASSAY; CALIBRATION; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMBINATORIAL LIBRARY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HYDROLYSIS; DRUG METABOLISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TOXICITY; DRUG TRANSPORT; EMPIRICISM; HUMAN; LIPOPHILICITY; METHODOLOGY; MOLECULAR MODEL; PHARMACOKINETICS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TETRAHYMENA PYRIFORMIS; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS; ARTICLE; CELL FUNCTION; COMBINATORIAL CHEMISTRY; COMPUTER SIMULATION; DRUG DESIGN; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

TETRAHYMENA; TETRAHYMENA PYRIFORMIS;

BIOLOGICAL TRANSPORT; CELL PHYSIOLOGY; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER SIMULATION; DRUG DESIGN; DRUG TOXICITY; PHARMACOKINETICS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036010699     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1093-3263(01)00149-8     Document Type: Conference Paper

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