DNA damage in nasal respiratory epithelium from children exposed to urban pollution

Environmental and Molecular Mutagenesis

Volumn 30, Issue 1, 1997, Pages 11-20

  Calderón Garcidueñas, Lilian ^a,d   Osnaya, Norma ^a   Rodríguez Alcaraz, Antonio ^b   Villarreal Calderón, Anna ^c  

^a INSTITUTO NACIONAL DE PEDIATRÍA   (Mexico)

^b Soc Mex ORL y CCC   (Mexico)

^c DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^d NONE   (Mexico)

Author keywords

Children's DNA damage; Comet assay; DNA strand breaks; Nasal epithelium; Ozone; Urban pollution

Indexed keywords

AIR POLLUTANT; AIR POLLUTION; ARTICLE; CHILD; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; FEMALE; GEL ELECTROPHORESIS; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTAGENICITY; NOSE MUCOSA;

AIR POLLUTION; CELL SURVIVAL; CHILD; DNA DAMAGE; ELECTROPHORESIS, AGAR GEL; EPISTAXIS; EPITHELIUM; FEMALE; HUMANS; MALE; MEXICO; NASAL MUCOSA; OZONE; URBAN HEALTH;

EID: 1842298213     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1997)30:1<11::AID-EM3>3.0.CO;2-F     Document Type: Article

References (55)

1. Baker M, He S (1991): Elaboration of cellular DNA breaks by hydroperoxides. Free Radicals Biol Med 11:563-572.
2. Bascom R, Bromberg PA, Costa DA, Devlin R, Dockery DW, Frampton MW, Lambert W, Sarnet JM, Speizer FE, Utell M (1996): Health effects of outdoor pollution, Part I. Am J Respir Crit Care Med 153:3-50.
3. Bermudez E (1991): Assessment of genotoxic effects in rat nasal epithelium. In Barrow CS (ed): "Toxicology of the Nasal Passages." New York: Hemisphere, pp 275-290.
4. Blake DR, Rowland FS (1995): Urban leakage of liquefied petroleum gas and its impact on Mexico City air quality. Science 269:953-956.
5. Bogdanffy MS, Morgan PH, Starr TB, Morgan KT (1987): Binding of formaldehyde to human and rat nasal mucosa and bovine serum albumin. Toxicol Lett 38:145-154.
6. Calderón-Garcidueñas L, Osorno-Velazquez A, Bravo-Alvarez H, Delgado-Chavez R, Barrios-Márquez R (1992): Histopathological changes of the nasal mucosa in southwest metropolitan Mexico City inhabitants. Am J Pathol 140:225-232.
7. Calderón-Garcidueñas L, Rodríguez-Alcaraz A, García R, Sánchez G, Barragán G, Camacho R, Ramírez L (1994): Human nasal mucosal changes after exposure to urban pollution. Environ Health Perspect 102:1074-1080.
8. Calderón-Garcidueñas L, Osnaya-Brizuela N, Ramírez-Martínez L, Villarreal-Calderón A (1996): DNA strand breaks in human nasal respiratory epithelium are induced upon exposure to urban pollution. Environ Health Perspect 104:160-168.
9. Casanova M, Morgan KT, Steinhagen WH, Everitt JI, Popp JA, Heck H d'A (1991): Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of Rhesus monkeys: Pharmacokinetics, rat-to monkey interspecies scaling and extrapolation to man. Fund Appl Toxicol 17:409-428.
10. Cassee FR, Feron VJ (1994): Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination. Toxicol Lett 7 2:257-268.
11. Chang L, Miller FG, Ultman J, Huang Y, Stockstill BL, Grose EC, Menache MG, Miller FG, Costa DL, Crapo JD (1991): Alveolar epithelial injury by subchronic exposure to low concentrations of ozone correlate with cumulative exposure. Toxicol Appl Pharmacol 109:219-234.
12. Cheng KC, Cahill DS, Kasai H, Nishimura S, Loeb LA (1992): 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G → T and A → C substitutions. J Biol Chem 267:166-172.
13. Cochrane CG (1991): Mechanisms of oxidant injury of cells. Mol Aspect Med 12:137-147.
14. Cross AE, Halliwell B, Allen A (1984): Antioxidant protection: A function of tracheobronchial and gastrointestinal mucus. Lancet 1:1328-1330.
15. Darzynkiewicz Z, Li X, Gong J (1994): Assays of Cell Viability: discrimination of cells dying by apoptosis. In Darzynkiewicz Z (ed): "Flow Cytometry." San Diego, CA: Academic Press, pp 15-38.
16. Farber E, Rubin H (1991): Cellular adaptation in the origin and development of cancer. Cancer Res 51:702-722.
17. Feig DI, Reid TM, Loeb LA (1994): Reactive oxygen species in tumorigenesis. Cancer Res 54:1890-1894.
18. Gaicía-Gutiérrez A, Herrera-Hernandez M, Bravo-Alvarez H (1991): Campus ozone concentrations related to new blends in gasoline sold in Mexico City: A statistical analysis. J Air Waste Manag Assoc 145:A115-4.
19. Hahn I, Scherer PW, Mozell MM (1993): Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. J Appl Physiol 75:2273-2287.
20. Hamelin C (1985): Production of single and double-strand breaks in plasmid DNA by ozone. Int J Radiat Oncol 11:253-257.
21. Hanley NM, Kozumbo WK, Costa DL, Tice RR, Madden MC (1993): Induction of DNA single strand breaks in lung cells by ozone exposure in vivo and in vitro. Am Rev Respir Dis 147:A670.
22. Harkema JR, Hotchkiss JA (1995): Ozone-induced proliferative and metaplastic lesions in nasal transitional and respiratory epithelium. In Miller FJ (ed): "Comparative Pathology: Nasal Toxicity and Dosimetry of Inhaled Xenobiotics." Washington, DC: Taylor and Francis, pp 187-204.
23. Harkema JR, Plopper CG, Hyde DM, St. George J, Wilson DW, Dungworth DL (1987): Response of the macaque nasal epithelium to ambient levels of ozone: a morphologic and morphometric study of the transitional and respiratory epithelium. Am J Pathol 128:29-44.
24. Harkema JR, Hotchkiss JA, Henderson FR (1989): Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial mucosubstances: Quantitative histochemistry. Toxicol Pathol 17:525-535.
25. Harkema JR, Plopper CG, Hyde DM, St. George JA, Wilson DW, Dungworth DL (1993): Response of macaque bronchiolar epithelium to ambient concentrations of ozone. Am J Pathol 143:857-866.
26. Hatch GE, Harkema JR, Graham RC (1995): Ozone dosimetry studies in the nose and eye using oxygen-18. In Miller FJ (ed): "Nasal Toxicity and Dosimetry of Inhaled Xenobiotics." Washington, DC: Taylor and Francis, pp 125-134.
27. Henderson RF, Hotchkiss JA, Chang IY, Scott BR, Harkema JR (1993): Effect of cumulative exposure in nasal response to ozone. Toxicol Appl Pharmacol 119:59-65.
28. Hu L, Crowe DL, Rheinwald JG, Chambon P, Gudas LJ (1991): Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines. Cancer Res 51:3972-3981.
29. Hu X, Ro JY, Lee JS, Shin DM, Hong WK, Lotan R (1994): Differential expression of nuclear retinoid receptors in normal, premalignant and malignant head and neck tissues. Cancer Res 54:3580-3587.
30. Jiang XZ, Morgan KT, Beauchamp RO (1986): Histopathology of acute and subacute nasal toxicity. In Barrow CS (ed): "Toxicology of the Nasal Passages." New York: Hemisphere, pp 51-66.
31. Kimbell JS, Morgan KT (1991): Airflow effects on regional disposition of particles and gases on the upper respiratory apparatus. Radiat Dosim Protec 38:213-219.
32. Kimbell JS, Gross EA, Joyner DR, Godo MN, Morgan KT (1993): Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol Appl Pharmacol 121:253-263.
33. Kozumbo WJ, Hanley NM, Agarwal S, Thomas MJ, Madden MC (1996): Products of ozonized arachidonic acid potentiate the formation of DNA single strand breaks in cultured human lung cells. Environ Mol Mutagen 27:185-195.
34. Lancillotti F, Darwiche N, Celli G, De Luca LM (1992): Retinoid status and the control of keratin expression and adhesion during histogenesis of squamous metaplasia of tracheal epithelium. Cancer Res 52:6144-6152.
35. Lee JG, Madden MC, Hatch GE, Bottei G, Reed W, Adler KB, Devlin RB (1995): Ozone exposure in vivo induces increases in DNA single strand breaks in human and guinea pig lung cells. Am J Respir Crit Care Med 151:A498.
36. Lippman M (1993): Health effects of trophospheric ozone: Review of recent research findings and their implications to ambient air quality standards. J Exp Anal Environ Epidemiol 3:103-129.
37. Madden MC, Friedman M, Hanley N, Siegler E, Quay J, Becker S, Devlin RB, Koren HS (1993): Chemical nature and immunotoxicological properties of arachidonic acid degradation products formed by exposure to ozone. Environ Health Perspect 101:154-164.
38. McDonald RJ, Ducore JM (1993): Hydrogen peroxide induces DNA single strand breaks in respiratory epithelial cells. Inflammation 17:715-722.
39. Monticello TM, Morgan KT (1995): Nasal lesion distribution and toxicity in the squamous epithelial region. In Miller FJ (ed): "Nasal Toxicity and Dosimetry of Inhaled Xenobiotics." Washington, DC: Taylor and Francis, pp 177-186.
40. Morgan KT, Monticello TM (1990): Airflow, gas deposition, and lesion distribution in the nasal passages. Environ Health Perspect 85:209-218.
41. Morgan KT, Jiang XZ, Starr TB, Kerns WD (1986): More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas. Toxicol Appl Pharmacol 82:264-271.
42. Morris JB, Clay RJ, Cavanagh DH (1986): Species differences in upper respiratory tract deposition of acetone and ethanol vapors. Fundam Appl Toxicol 7:671-680.
43. Nelson WG Kastan MB (1994): DNA strand breaks: The DNA template alterations that trigger p-53 dependent DNA damage response pathways. Mol Cell Biol 14:1815-1823.
44. Pino MV, Levin JR, Stovall MY, Hyde DM (1992): Pulmonary inflammation and epithelial injury in response to acute ozone exposure in the rat. Toxicol Appl Pharmacol 112:64-72
45. Pryor WA (1994): Mechanisms of radical formation from reaction to ozone with target molecules in the lung. Free Radicals Biol Med 17:451-465.
46. Reuzel PG, Wilmer JGM, Woutersen RA, Zwart A, Rombout PJA, Feron VJ (1990): Interactive effects of ozone and formaldehyde on the nasal respiratory lining epithelium in rats. J Toxicol Environ Health 29:279-292.
47. Singh NP, McCoy MT, Tice RR, Schneider EL (1988): A simple technique for the quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
48. Stockstill BL, Chang LY, Menache MG, Mellick PW, Mercer RR, Crapo JD (1995): Bronchiolarized metaplasia and interstitial fibrosis in rat lungs chronically exposed to high ambient levels of ozone. Toxicol Appl Pharmacol 134:251-263.
49. Tepper JS, Costa DL, Lehmann JR, Weber MF, Hatch GE (1989): Unattenuated structural and biochemical alterations in the rat lung during functional adaptation to ozone. Am Rev Respir Dis 140:493-501.
50. Tice RR (1995): The single cell gel/comet assay: A microgel electrophoretic technique for the detection of DNA damage and repair in individual cells. In Phillip DH, Venitt S (eds): "Environmental Mutagenesis." Oxford, UK: Bios Scientific Publishers, pp 315-337.
51. Victorin K (1992): Review of the genotoxicity of ozone. Mutat Res 277:221-238.
52. Ward AJ, Olive PL, Burr AH, Rosin MP (1993): A sensitivity to oxidative stress is linked to chromosome 11 but is not due to a difference in single strand DNA breakage or repair. Mutat Res 294:299-308.
53. Wolf DC, Morgan KT, Gross EA, Barrow C, Moss OR, James RA, Popp JA (1995): Two-year inhalation exposure of female and male B6C3F1 mice and F-344 rats to chlorine gas induces lesions confined to the nose. Fundam Appl Toxicol 24:111-131.
54. Yarborough A, Zhang YJ, Hsu TM, Santella RM (1996): Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin 1-treated rat liver and human oral mucosal cells. Cancer Res 56:683-688.
55. Zhuang Z, Vortmeyer AO, Mark EJ, Odze R, Emmert-Buck MR, Merino MJ, Moon H, Liotta LA, Duray PH (1996): Barrett's esophagus: Metaplastic cells with loss of heterozygocity at the APC gene locus are clonal precursors to invasive adenocarcinoma. Cancer Res 56:1961-1964.