Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes

Toxicological Sciences

Volumn 55, Issue 2, 2000, Pages 392-398

  Henriksson, Jörgen ^a   Tjälve, Hans ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Astrocytes; GFAP; Intranasal administration; Manganese; Olfactory pathway; S 100b

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MANGANESE; PROTEIN S 100;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL COUNT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; HIPPOCAMPUS; HYPOTHALAMUS; INTRANASAL DRUG ADMINISTRATION; MALE; NERVE CELL NECROSIS; NONHUMAN; OLFACTORY CORTEX; OLFACTORY SYSTEM; RAT; THALAMUS; TOXICITY TESTING;

ANIMALIA;

EID: 0034041099     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/55.2.392     Document Type: Article

References (51)

1. Albrecht, J. (1996). Astrocytes and ammonia. In The Role of Glia in Neurotoxicity (M. Aschner and H. K. Kimelberg, Eds.), pp. 137-153. CRC Press, Boca Raton.
2. Allison, A. C. (1953). The morphology of the olfactory system in the vertebrates. Biol. Rev. 28, 195-244.
3. Aschner, M. (1998). Astrocytic functions and physiological reactions to injury: the potential to induce and/or exacerbate neuronal dysfunction - a forum position paper. Neurotoxicology 19, 7-17.
4. Aschner, M., Gannon, M., and Kimelberg, H. K. (1992). Manganese uptake and efflux in cultured rat astrocytes. J. Neurochem. 58, 730-735.
5. Barbeau, A. (1984). Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C. Cotzias). Neurotoxicology 5, 13-35.
6. Bergman, U., and Brittebo, E. B. (1999). Methimazole toxicity in rodents: Covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb. Toxicol. Appl. Pharmacol. 155, 190-200.
7. Boyes, B. E., Kim, S. U., Lee, V., and Sung, S. C. (1986). Immunohistochemical co-localization of S-100b and the glial fibrillary acidic protein in rat brain. Neuroscience 17, 857-865.
8. Brodal, A. (1981). The olfactory pathways. The amygdala., The hippocampus., The limbic system. In Neurological Anatomy in Relation to Clinical Medicine, 3rd ed., pp. 640-697. Oxford University Press, New York.
9. Cragg, B. G. (1961). Olfactory and other afferent connections of the hippocampus in the rabbit, rat, and cat. Exp. Neurol. 3, 588-600.
10. Deamer, N. J., O'Callaghan, J. P., and Genter, M. B. (1994). Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57B1 mouse. Neurotoxicology 15, 287-294.
11. Donaldson, J. (1987). The physiopathologic significance of manganese in brain: its relation to schizophrenia and neurodegenerative disorders. Neurotoxicology 8, 451-462.
12. Eng, L. F. (1988). Regulation of glial intermediate filaments in astrogliosis. In Biochemical Pathology of Astrocytes (M. D. Norenberg, L. Hertz, and A. Schousboe, Eds.), pp. 79-90. A. R. Liss, New York.
13. Fano, G., Biocca, S., Fulle, S., Mariggio, M., Belia, S., and Calissano, P. (1995). The S-100: a protein family in search of a function. Prog. Neurobiol. 4, 71-82.
14. Gavin, C. E., Gunter, K. K., and Gunter, T. E. (1999). Manganese and calcium transport in mitochondria: implications for manganese toxicity. Neurotoxicology 20, 445-453.
15. Genter, M. B., Llorens, J., O'Callaghan, J. P., Peele, D. B., Morgan, K. T., and Crofton, K. M. (1992). Olfactory toxicity of β,β′-iminodipropionitrile in the rat. J. Pharmacol. Exp. Ther. 263, 1432-1439.
16. Green, A. J., Harvey, R. J., Thompson, E. J., and Rossor, M. N. (1997). Increased S100β in the cerebrospinal fluid of patients with frontotemporal dementia. Neurosci. Lett. 235, 5-8.
17. Griffin, W. S. T, Stanley, L. C., Yeralan, O., Rovnaghi, C. R., and Marshak, D. R. (1993). Cytokines in human neurodegenerative disease. Meth. NeuroSci. 17, 268-287.
18. Haan, E. A., Boss, B. D., and Cowan, W. M. (1982). Production and characterization of monoclonal antibodies against the "brain-specific" proteins 14-3-2 and S-100. Proc. Natl. Acad. Sci. U S A 79, 7585-7589.
19. Haberly, L. B. (1990). Olfactory cortex. In The Synaptic Organization of the Brain (G. M. Shepherd, Ed.), pp. 319-345. Oxford University Press, New York.
20. Henriksson, J., Tallkvist, J., and Tjälve, H. (1999). Transport of manganese via olfactory pathway in rats: dosage dependency of the uptake and subcellular distribution of the metal in the olfactory epithelium and the brain. Toxicol. Appl. Pharmacol. 156, 119-128.
21. Imai, Y., Ibata, I., Ito, D., Ohsawa, K. and Kohsaka, S. (1996). A novel gene, iba1, in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage. Biochem. Biophys. Res. Commun. 224, 855-862.
22. Ito. D., Imai, Y., Ohsawa, K., Nakajima, K., Fukuuchi, Y., and Kohsaka, S. (1998). Microglia-specific localization of a novel calcium-binding protein, Iba1. Brain Res. Mol. Brain Res. 57, 1-9.
23. Itoyama, Y., Sekizawa, T., Openshaw, H., Kogure, K., and Goto, I. (1991). Early loss of astrocytes in herpes simplex virus-induced central nervous system demyelination. Ann. Neurol. 29, 285-292.
24. Khurgel, M., Koo, A. C., and Ivy, G. O. (1996). Selective ablation of astrocytes by intracerebral injections of α-aminoadipate. Glia 16, 351-358.
25. Kreutzberg, G. W. (1996). Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312-318.
26. Kristensson, K., Eriksson, H., Lundh, B., Plantin, L. O., Wachtmeister, L., el Azazi, M., Morath, C., and Heilbronn, E. (1986). Effects of manganese chloride on the rat developing nervous system. Acta Pharmacol. Toxicol. 59, 345-348.
27. Lafarga, M., Andres, M. A., Calle, E., and Berciano, M. T. (1998). Reactive gliosis of immature Bergmann glia and microglial cell activation in response to cell death of granule cell precursors induced by methylazoxymethanol treatment in developing rat cerebellum. Anat. Embryol. 198, 111-122.
28. Mergler, D., and Baldwin, M. (1997). Early manifestations of manganese neurotoxicity in humans: an update. Environ. Res. 73, 92-100.
29. Merrill. J., and Murphy, S. (1996). Nitric oxide. In The Role of Glia in Neurotoxicity (M. Aschner and H. K. Kimelberg, Eds.), pp. 263-281. CRC Press, Boca Raton.
30. O'Callaghan, J. P. (1991). Quantification of glial fibrillary acidic protein: Comparison of slot-immunobinding assays with a novel sandwich ELISA. Neurotoxicol. Teratol. 13, 275-281.
31. O'Callaghan, J. P., Jensen, K. F., and Miller, D. B. (1995). Quantitative aspects of drug and toxicant-induced astroglios. Neurochem. Int. 26, 115-124.
32. Ohsawa, K., Imai, Y., Nakajima, K., and Kohsaka, S. (1997). Generation and characterization of a microglial cell line, MG5, derived from a p53-deficient mouse. Glia 21, 285-298.
33. Olanow, C. W., Good, P. F., Shinotoh, H., Hewitt, K. A., Vingerhoets, F., Snow, B. J., Beal, M. F., Calne, D. B., and Perl, D. P. (1996). Manganese intoxication in rhesus monkey: a clinical, imaging, pathologic, and biochemical study. Neurology 46, 492-498.
34. Pappas, B. A., Zhang, D., Davidson, C. M., Crowder, T., Park, G. A., and Fortin. T. (1997). Perinatal manganese exposure: behavioral, neurochemical, and histopathological effects in the rat. Neurotoxicol. Teralol. 19, 17-25.
35. Penkowa, M., Giralt, M., Moos, T., Thomsen, P., Hernández, J., and Hidalgo, J. (1999). Impaired inflammatory response to glial-cell death in genetically metallothionein-I- and -II-deficient mice. Exp. Neurol. 156, 149-164.
36. Penkowa, M., Hidalgo, J., and Moos, T. (1997). Increased astrocytic expression of metallothioneins I + II in brainstem of adult rats treated with 6-aminonicotinamide. Brain Res. 774, 256-259.
37. Price, J. L. (1985). Beyond the primary olfactory cortex: olfactory-related areas in the neocortex, thalamus, and hypothalamus. Chem. Senses 10, 239-258.
38. Raivich, G., Bohatschek, M., Kloss, C. U., Werner, A., Jones, L. L., and Kreutzberg, G. W. (1999). Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms, and cues to physiological function. Brain Res. Rev. 30, 77-105.
39. Schmidt-Kastner, R., and Ingvar, M. (1994). Loss of immunoreactivity for glial fibrillary acidic protein (GFAP) in astrocytes as a marker for profound tissue damage in substantia nigra and basal cortical areas after status epilepticus induced by pilocarpine in rat. Glia, 12, 165-172.
40. Schmued, L. C., Albertson, C., and Slikker W., Jr. (1997). Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751, 37-46.
41. Schwerdtfeger, W. K., Buhl, E. H., and Germroth, P. (1990). Disynaptic olfactory input to the hippocampus mediated by stellate cells in the entorhinal cortex. J. Comp. Neurol. 292, 163-177.
42. Shinotoh, H., Snow, B. J., Chu, N. S., Huang, C. C. Lu, C. S., Lee, C., Takahashi, H., and Calne, D. B. (1997). Presynaptic and postsynaptic striatal dopaminergic function in patients with manganese intoxication: a positron emission tomography study. Neurology 48, 1053-1056.
43. Sloot, W. N., and Gramsbergen, J. B. (1994). Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Res. 657, 124-132.
44. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985). Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
45. Spranger, M., Schwab, S., Desiderato, S., Bonmann, E., Krieger, D., and Fandrey, J. (1998). Manganese augments nitric oxide synthesis in murine astrocytes: a new pathogenic mechanism in manganism?. Exp. Neurol. 149, 277-283.
46. Tjälve, H., Henriksson, J., Tallkvist, J., Larsson, B. S., and Lindquist, N. G. (1996). Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol Toxicol. 79, 347-356.
47. Tjälve, H., Mejàre, C., and Borg-Neczak, K. (1995). Uptake and transport of manganese in primary and secondary olfactory neurones in pike. Pharmacol. Toxicol. 77, 23-31.
48. Verity, M. A. (1999). Manganese neurotoxicity: a mechanistic hypothesis. Neurotoxicology 20, 489-497.
49. Wedler, F. C., and Denman, R. B. (1984). Glutamine synthetase: The major Mn(II) enzyme in mammalian brain. Curr. Top. Cell. Regul. 24, 153-169.
50. Wedler, F. C., Ley, B. W., and Grippo, A. A. (1989). Manganese(II) dynamics and distribution in glial cells cultured from chick cerebral cortex. Neurochem. Res. 14, 1129-1135.
51. Yamada, M., Ohno, S., Okayasu, I., Okeda, R., Hatakeyama, S., Watanabe, H., Ushio, K., and Tsukagoshi, H. (1986). Chronic manganese poisoning: a neuropathological study with determination of manganese in the brain. Acta Neuropathol. 70, 273-278.