Cations affect the rate of gating charge recovery in wild-type and W434F Shaker channels through a variety of mechanisms

Journal of General Physiology

Volumn 119, Issue 5, 2002, Pages 467-485

  Varga, Zoltan ^a   Rayner, Martin D ^b   Starkus, John G ^a,c  

^a UNIVERSITY OF HAWAII   (United States)

^b UNIVERSITY OF HAWAII   (United States)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Barium; C inactivation; Gating current; P inactivation; Potassium channels

Indexed keywords

BARIUM; POTASSIUM CHANNEL; DIVALENT CATION; MONOVALENT CATION; PHENYLALANINE; SHAKER POTASSIUM CHANNEL; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; CHANNEL GATING; FEMALE; ION PERMEABILITY; MOLECULAR INTERACTION; NONHUMAN; PROTEIN EXPRESSION; REGULATORY MECHANISM; REPOLARIZATION; AMINO ACID SUBSTITUTION; ANIMAL; DRUG EFFECT; ELECTRIC CONDUCTIVITY; GENETICS; METABOLISM; OOCYTE; PHYSIOLOGY; POINT MUTATION; XENOPUS LAEVIS;

AMINO ACID SUBSTITUTION; ANIMAL; BARIUM; CATIONS, DIVALENT; CATIONS, MONOVALENT; ELECTRIC CONDUCTIVITY; FEMALE; ION CHANNEL GATING; OOCYTES; PHENYLALANINE; POINT MUTATION; POTASSIUM CHANNELS; SUPPORT, U.S. GOV'T, P.H.S.; TRYPTOPHAN; XENOPUS LAEVIS; ANIMALS; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS;

EID: 0035999834     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028520     Document Type: Article

References (41)

1. +]: A tale of two inactivation mechanisms
2. + channel
3. + channels: II. The components of gating currents and a model of channel activation
4. + channel deactivation
5. + channel correlate with occupancy of the pore
6. + conduction and selectivity
7. Modulation of slow inactivation in human cardiac Kv1.5 channels by extra- and intracellular permeant cations
8. + channel
9. Recording of gating currents from Xenopus oocytes and gating noise analysis
10. + channels: Effects of alterations in the carboxy-terminal region
11. External barium block of Shaker potassium channels: Evidence for two binding sites
12. External barium influences the gating charge movement of Shaker potassium channels
13. The role of the divergent amino and carboxyl domains on the inactivation properties of potassium channels derived from the Shaker gene of Drosophila
14. The barium site in a potassium channel by x-ray crystallography
15. + at the potassium channel selectivity filter
16. Permeation selectivity by competition in a delayed rectifier potassium channel
17. Recovery from C-type inactivation is modulated by extracellular potassium
18. +
19. + channel
20. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels
21. External monovalent cations that impede the closing of K channels
22. + channels
23. Mechanism underlying slow kinetics of the off gating current in Shaker potassium channel
24. Patch clamp measurements of Xenopus laevis oocytes: Currents through endogenous channels and implanted acetylcholine receptor and sodium channels
25. + channel
26. Potassium blocks barium permeation through a calcium-activated potassium channel
27. + channels
28. + channels
29. Incubation with horse serum increases viability and decreases background neurotransmitter uptake in Xenopus oocytes
30. + fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes
31. Ion conduction through C-type inactivated Shaker channels
32. + currents in the "Nonconducting" Shaker potassium channel mutant W434F
33. Slow inactivation changes the relationship between channel closing and gating charge return in Shaker potassium channels
34. Electrophysiological recording from Xenopus oocytes
35. +
36. Affinity and location of an internal K(+) ion binding site in Shaker K channels
37. Ionic current deactivation and gating charge return in slow inactivated Shaker mutants
38. Gating charge immobilization caused by the transition between inactivated states in the Kv1.5 channel
39. A high-Na(+) conduction state during recovery from inactivation in the K(+) channel Kv1.5
40. + channel deactivation
41. How does the W434F mutation block current in Shaker potassium channels?