Clearance characteristics of chitosan based formulations in the sheep nasal cavity

International Journal of Pharmaceutics

Volumn 217, Issue 1-2, 2001, Pages 183-191

  Soane, R J ^a   Hinchcliffe, M ^b   Davis, S S ^a,b   Illum, L ^a,b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Drug Delivery and Clinical Research Centre Ltd   (United Kingdom)

Author keywords

Bioadhesion; Chitosan; Gamma scintigraphy; Nasal drug delivery; Sheep model

Indexed keywords

CHITOSAN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HALF LIFE; MEAN RESIDENCE TIME; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; SHEEP;

ADHESIVES; ANIMALS; BIOCOMPATIBLE MATERIALS; CHITIN; CHITOSAN; DRUG DELIVERY SYSTEMS; MICROSPHERES; NASAL CAVITY; RADIOPHARMACEUTICALS; SHEEP; SODIUM PERTECHNETATE TC 99M;

EID: 0035901694     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00602-0     Document Type: Article

References (35)

1. Distribution and removal of human serum albumin - Technetium 99m instilled intranasally
2. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
3. Chitosan as a nasal delivery system: Evaluation of the effect of chitosan on mucociliary clearance rate in the frog palate model
4. Chitosan as a nasal delivery system: The effect of chitosan on in vitro and in vivo mucociliary transport rates
5. Transmucosal absorption promoters: Efficacy, mechanisms and safety concerns
6. Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system
7. Effect of chitosan on epithelial permeability and structure
8. Nasal administration of insulin using bioadhesive microspheres and lysophosphatidylcholine as a delivery system
9. Sedimentation analysis of potential interactions between mucus and putative bioadhesive polymer
10. Effect of l-α-lysophosphatidylcholine on the nasal absorption of human growth hormone in three animal species
11. Animal models for intranasal drug delivery studies
12. Model of disposition of drugs administered into the human nasal cavity
13. Intranasal drug delivery by spray and drops
14. Intranasal administration of peptides: Nasal deposition, biological response and absorption of desmopressin
15. In vitro evaluation of the mucoadhesive properties of chitosan microspheres
16. Bioadhesion of hydrated chitosans: An in vitro and in vivo study
17. Nasal absorption enhancement of 17β-oestradiol by dimethyl-β-cyclodextrin in rabbits and rats
18. Nasal delivery of peptides, factors affecting nasal absorption
19. Nasal delivery. The use of animal models to predict performance in man
20. Transport of drugs from the nasal cavity to the central nervous system
21. Chitosan as a novel nasal delivery system for peptide drugs
22. Novel chitosan based delivery systems for nasal administration of a LHRH-analogue
23. Nasal absorption enhancement of 17b-oestradiol with bioadhesive microparticles in sheep
24. Intranasal bioavailability of insulin powder formulations: Effect of permeation enhancer-to-protein ratio
25. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
26. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo
27. Nasal absorption of dihydroergotamine from liquid and powder formulations in rabbits
28. Mucosal adhesive dosage forms
29. Nasal mucociliary function in normal man
30. Mucociliary transport in vitro and in vivo
31. Enhanced peptide absorption by the mucoadhesive polymers polycarbophil and chitosan
32. Chitosans as absorption enhancers for poorly absorbable drugs 2: Mechanism of absorption enhancement
33. On mucociliary transport
34. Evaluation of the clearance characteristics of bioadhesive systems in humans
35. Comparison of nasal deposition and clearance of aerosol generated by nebulizer and an aqueous spray pump