Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients

FASEB Journal

Volumn 14, Issue 11, 2000, Pages 1529-1538

  Kardinal, C ^a   Konkol, B ^a   Schulz, A ^a   Posern, G ^a   Lin, H ^a   Adermann, K ^a   Eulitz, M ^a   Estrov, Z ^a   Talpaz, M ^a   Arlinghaus, R B ^a   Feller, S M ^a  

^a MSZ   (Germany)

Author keywords

Adapter protein; Bcr Abl; CRKL; MAP kinase (MAPK)

Indexed keywords

BCR ABL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE;

ARTICLE; BINDING AFFINITY; BLAST CELL; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

EID: 0033869550     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.99-0850com     Document Type: Article

References (36)

1. Biology of chronic myelogenous leukemia
2. The chimeric BCR-ABL gene
3. The involvement of Bcr in leukemias with the Philadelphia chromosome
4. The biology of chronic myeloid leukemia
5. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
6. Physiological signals and oncogenesis mediated through Crk family adapter proteins
7. Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins
8. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk
9. Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G
10. Preparation of disulfide-bonded heterodimers by titration of thioactivated peptides with thiol-containing peptides
11. Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL)
12. Trojan peptides: The penetration system for intracellular delivery
13. Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs
14. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
15. Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non-endocytically
16. Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk
17. Signal transduction-based strategies for the treatment of chronic myelogenous leukemia
18. CRKL binding to BCR-ABL and BCR-ABL transformation
19. A model of Ph' positive chronic myeloid leukemia-blast crisis cell line growth in immunodeficient SCID mice
20. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase
21. Expansion of Philadelphia chromosome-negative CD3 (+) CD56 (+) cytotoxic cells from chronic myeloid leukemia patients: In vitro and in vivo efficacy in severe combined immunodeficiency disease mice
22. BCR/ABL-mediated leukemogenesis requires the activity of the small GTP-binding protein Rac
23. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
24. Bcr-Abl efficiently induces a myeloproliferafive disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: A novel model for chronic myelogenous leukemia
25. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
26. Growth factor independence and BCR/ABL transformation: Promise and pitfalls of murine model systems and assays
27. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors
28. Flexibility of interdomain contacts revealed by topological isomers of bivalent consolidated ligands to the dual Src homology domain SH (32) of Abelson
29. Selective inhibition of growth factor-stimulated mitogenesis by a cell-permeable Grb2-binding peptide
30. A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity
31. A peptide isolated from phage display libraries is a structural and functional mimic of an RGD-binding site on integrins
32. Organ targeting in vivo using phage display peptide libraries
33. Alpha v integrins as receptors for tumor targeting by circulating ligands
34. Chemotherapy targeted to tumor vasculature
35. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
36. The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck