Spinal neurokinin NK1 receptor down-regulation and antinociception: Effects of spinal NK1 receptor antisense oligonucleotides and nk1 receptor occupancy

Journal of Neurochemistry

Volumn 70, Issue 2, 1998, Pages 688-698

  Hua, Xiao Ying ^a   Chen, Ping ^a   Polgar, Erika ^b   Nagy, Istvan ^c   Marsala, Martin ^a   Phillips, Elsa ^c   Wollaston, Laura ^c   Urban, Laszlo ^c   Yaksh, Tony L ^a   Webb, Michael ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c Novatis Inst for Medical Sciences   (United Kingdom)

Author keywords

Antinociception; Antisense oligonucleotide; NK1 receptor; Spinal cord; Substance P

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; ANTISENSE OLIGONUCLEOTIDE; COMPLEMENTARY DNA; FORMALDEHYDE; MESSENGER RNA; NEUROKININ 1 RECEPTOR; NOLPITANTIUM; SUBSTANCE P; TACHYKININ RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; HYPERALGESIA; INTRATHECAL DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; RECEPTOR OCCUPANCY; SPINAL CORD; SPINAL GANGLION;

ANIMALIA;

EID: 0031889238     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70020688.x     Document Type: Article

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