The NMDA antagonist memantine impairs classical eyeblink conditioning in humans

Neuroscience Letters

Volumn 224, Issue 1, 1997, Pages 57-60

  Schugens, Markus M ^a   Egerter, Ralf ^a   Daum, Irene ^a   Schepermann, Karsten ^a   Klockgether, Thomas ^a   Löschmann, Peter A ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

cerebellum; classical eyeblink conditioning; memantine; memory systems; N methyl D aspartate

Indexed keywords

MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; CEREBELLUM; CLINICAL TRIAL; CONDITIONING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EYELID REFLEX; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; MEMORY; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; AFFECT; BLINKING; CONDITIONING, CLASSICAL; DOUBLE-BLIND METHOD; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; LEARNING; MALE; MEMANTINE; MEMORY; N-METHYLASPARTATE;

EID: 0031054229     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)13452-8     Document Type: Article

References (21)

1. Bear, M.F., Kleinschmidt, A., Gu, Q.A. and Singer, W., Disruption of experience-dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist, J. Neurosci., 10 (1990) 909-925.
2. Benton, A.L., The Revised Visual Retention Test, Psychological Corporation, New York, 1955.
3. Bliss, T.V. and Collinridge, G.L., A synaptic model of memory: long-term potentiation in the hippocampus, Nature, 361 (1993) 31-39.
4. Bond, A. and Lader, M., The use of analogue scales in rating subjective feelings, Br. J. Med. Psychol., 47 (1974) 211-218.
5. Bresink, I., Danysz, W., Parsons, C.G. and Mutschler, E., Different binding affinities of NMDA receptor channel blockers in various brain regions - indication of NMDA receptor heterogenity, Neuropharmacology, 34 (1995) 533-540.
6. Brickenkamp, R., Test d2. Aufmerksamkeits-Belastungstest, Hogrefe, Göttingen, 1981.
7. Daum, I., Ackermann, H., Schugens, M.M., Reimold, C., Dichgans, J. and Birbaumer, N., The cerebellum and cognitive functions in humans, Behav. Neurosci., 107 (1993) 411-419.
8. Daum, I. and Schugens, M.M., On the cerebellum and classical conditioning, Curr. Dir. Psychol. Sci., 5 (1996) 58-61.
9. Daum, I., Schugens, M.M., Ackermann, H., Lutzenberger, W., Dichgans, J. and Birbaumer, N., Classical conditioning after cerebellar lesions in humans, Behav. Neurosci., 107 (1993) 748-756.
10. Daum, I., Schugens, M.M., Spieker, S., Poser, U., Schönle, P.W. and Birbaumer, N., Memory and skill acquisition in Parkinson's disease and frontal lobe dysfunction, Cortex, 31 (1995) 413-432.
11. Ditzler, K., Efficacy and tolerability of memantine in patients with dementia syndrome, Drug Res., 41 (1991) 773-780.
12. Kornhuber, J., Bormann, J., Hubers, M., Rusche, K. and Riederer, P., Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study, Eur. J. Pharmacol., 206 (1991) 297-300.
13. Krystal, J.H., Karper, L.P., Seibyl, J.P., Freeman, G.K., Delaney, R., Bremner, J.D., Heninger, G.R., Bowers, M.B. and Charney, D.S., Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses, Arch. Gen. Psychiatry, 51 (1994) 199-213.
14. Porter, R.H. and Greenamyre, J.T., Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential, J. Neurochem., 64 (1995) 614-623.
15. Rey, A., L'examen psychologique dans les cas d'encephalopathie traumatique, Arch. Psychol., 28 (1942) 112.
16. Robinson, G.B., MK801 retards acquisition of a classically conditioned response without affecting conditioning-related alterations in perforant path-granule cell synaptic transmission, Psychobiology, 21 (1993) 253-264.
17. Shapiro, M.L. and O'Connor, C., N-Methyl-D-aspartate receptor antagonist MK-801 and spatial memory representation: working memory is impaired in an unfamiliar environment but not in a familiar environment, Behav. Neurosci., 106 (1992) 604-612.
18. Shors, T.J., Servatius, R.J., Thompson, R.F., Rogers, G. and Lynch, G., Enhanced glutamatergic neurotransmission facilitates classical conditioning in the freely moving rat, Neurosci. Lett., 186 (1995) 153-156.
19. Squire, L.R., Memory and the hippocampus. A synthesis from findings with rats, monkeys and humans, Psychol. Rev., 99 (1992) 195-232.
20. Thompson, R.F. and Krupa, D.J., Organization of memory traces in the mammalian brain, Annu. Rev. Neurosci., 17 (1994) 519-549.
21. Wesemann, W., Sontag, K.-H. and Maj, J., Zur Pharmakodynamik und Pharmakokinetic des Memantin, Arzneim.-Forsch./Drug Res., 33 (1983) 1122-1134.