Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 829-838

  Chaplan, Sandra R ^a   Malmberg, Annika B ^a   Yaksh, Tony L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 PHOSPHONOPROPIONIC ACID; 2 AMINO 5 PHOSPHONOVALERIC ACID; 6,7 DINITRO 2,3 QUINOXALINEDIONE; DEXTROMETHORPHAN; DEXTRORPHAN; DIZOCILPINE; FORMALDEHYDE; GLUTAMATE RECEPTOR; KETAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; ETIOLOGY; HYPERALGESIA; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRATHECAL DRUG ADMINISTRATION; MALE; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

2-AMINO-5-PHOSPHONOVALERATE; ANALGESICS; ANIMALS; DEXTROMETHORPHAN; DEXTRORPHAN; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; FORMALDEHYDE; HYPERALGESIA; INJECTIONS, SPINAL; KETAMINE; MALE; MEMANTINE; MORPHINE; PAIN; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; SPINAL NERVES; TOUCH;

EID: 0030933616     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. BACH, F. W., CHAPLAN, S. R. AND YAKSH, T. L.: Studies on the spinal pharmacology of a new model of allodynia. Ann. Neurol. 36: 288A, 1994.
2. BACH, F. W. AND YAKSH, T. L.: Release of beta-endorphin immunoreactivity from brain by activation of a hypothalamic N-methyl-D-aspartate receptor. Neuroscience 65: 775-783, 1995.
3. BIELLA, G., LACERENZA, M., MARCHETTINI, P. AND SOTGIU, M. L.: Diverse modulation by systemic lidocaine of iontophoretic NMDA and quisqualic acid induced excitations on rat dorsal horn neurons. Neurosci. Lett. 157: 207-210, 1993.
4. BOCKERS, T. M., ZIMMER, M., MULLER, A., BERGMANN, M., BROSE, N. AND KREUTZ, M. R.: Expression of the NMDA R1 receptor in selected human brain regions. Neuroreport 5: 965-969, 1994.
5. BROSE, N., GASIG, G. P., VETTER, D. E., SULLIVAN, J. M. AND HEINEMANN, S. F.: Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1. J. Biol. Chem. 268: 22663-22671, 1993.
6. BULLER, A. L., LARSON, H. C., SCHNEIDER, B. E., BEATON, J. A., MORRISETT, R. A. AND MDNAGHAN, D. T.: The molecular basis of NMDA receptor subtypes: native receptor diversity is predicted by subunit composition. J. Neurosci. 14: 5471-5484, 1994.
7. CHAPLAN, S. R., BACH, F. W., POGREL, J. W., CHUNG, J. M. AND YAKSH, T. L.: Quantitative assessment of allodynia in the rat paw. J. Neurosci. Methods 53: 55-63, 1994.
8. CHAPMAN, V., DICKENSON, A. H. AND TJOLSEN, A.: Bi-directional effects of intrathecal NMDA and substance P on rat dorsal horn neuronal responses. Neurosci. Lett. 178: 90-94, 1994.
9. CHUNG, K., KIM, H. J., NA, H. S., PARK, M. J. AND CHUNG, J. M.: Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain. Neurosci. Lett. 162: 85-88, 1993.
10. CODERRE, T. J., KATZ, J., VACCARINO, A. L. AND MELZACK, R.: Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 52: 259-285, 1993.
11. CODERRE, T. J. AND MELZACK, R.: The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J. Neurosci. 12: 3665-3670, 1992.
12. CODERRE, T. J. AND VAN EMPEL, I.: The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests. Pain 59: 345-352, 1994.
13. CODERRE, T. J. AND YASHPAL, K.: Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model. Eur. J. Neurosci. 6: 1328-1334, 1994.
14. DAVAR, G., HAMA, A., DEYKIN, A., VOS, B. AND MACIEWICZ, R.: MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Res. 553: 327-330, 1991.
15. DAVIES, J. AND WATKINS, J. C.: Role of excitatory amino acid receptors in mono-and polysynaptic excitation in the cat spinal cord. Exp. Brain Res. 49: 280-290, 1983.
16. DAVIES, S. N. AND LODGE, D.: Evidence for involvement of N-methylaspartate receptors in "wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res. 424: 402-406, 1987.
17. DEVOR, M. AND GOVRIN-LIPPMANN, R.: Axoplasmic transport block reduces ectopic impulse generation in injured peripheral nerves. Pain 16: 73-85, 1983.
18. DICKENSON, A. H. AND SULLIVAN, A. F.: Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation. Neuropharmacology 26: 1235-1238, 1987.
19. DIXON, W. J.: Efficient analysis of experimental observations. Ann. Rev. Pharmacol. Toxicol. 20: 441-462, 1980.
20. DOUGHERTY, P. M. AND WILLIS, W. D.: Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist. Brain Res. 542: 15-22, 1991.
21. HARA, A., SAKURADA, T., SAKURADA, S., MATSUMURA, H. AND KISARA, K.: Antinociceptive effects of neonatal capsaicin in rats with adjuvant arthritis. Naunyn Schmiedeberg Arch. Pharmacol. 326: 248-253, 1984.
22. JENSEN, T. S. AND YAKSH, T. L.: The antinociceptive activity of excitatory amino acids in the rat brainstem: an anatomical and pharmacological analysis. Brain Res. 569: 255-267, 1992a.
23. JENSEN, T. S. AND YAKSH, T. L.: Brainstem excitatory amino acid receptors in nociception: Microinjection mapping and pharmacological characterization of glutamate-sensitive sites in the brainstem associated with algogenic behavior. Neuroscience 46: 535-547, 1992b.
24. KIM, S. H. AND CHUNG, J. M.: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50: 355-363, 1992.
25. KRISTENSEN, J. D., SVENSSON, B. AND GORDH, T.: The NMDA-receptor antagonist CPP abolishes neurogenic ''wind-up pain' after intrathecal administration in humans. Pain 51: 249-253, 1992.
26. KUTSUWADA, T., KASHIWABUCHI, N., MORI, H., SAKIMURA, K., KUSHIYA, E., ARAKI, K., MEGURO, H., MASAKI, H., KUMANISHI, T. AND ARAKAWA, M.: Molecular diversity of the NMDA receptor channel. Nature 358: 36-41, 1992.
27. LAURIE, D. J. AND SEEBURG, P. H.: Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA. J. Neurosci. 14: 3180-3194, 1994.
28. LEE, Y. W., CHAPLAN, S. R. AND YAKSH, T. L.: Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci. Lett. 186: 1-4, 1995.
29. LIU, H., WANG, H., SHENG, M., JAN, L. Y., JAN, Y. N. AND BASBAUM, A. I.: Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc. Natl. Acad. Sci. U.S.A. 91: 8383-8387, 1994.
30. Luo, L. AND WIESENFELD-HALLIN, Z.: The effects of pretreatment with tachykinin antagonists and galanin on the development of spinal cord hyperexcit-ability following sciatic nerve section in the rat. Neuropeptides 28: 161-166, 1995.
31. MALMBERG, A. B. AND YAKSH, T. L.: Antinociceptive actions of spinal nonsteroidal antiinflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther. 263: 136-146, 1992a.
32. MALMBERG, A. B. AND YAKSH, T. L.: Hyperalgesia mediated by spinal glutamate or substance-P receptor blocked by spinal cyclooxygenase inhibition. Science 257: 1276-1279, 1992b.
33. MALMBERG, A. B. AND YAKSH, T. L.: Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: A microdialysis study in unanesthetized rats. J. Neurosci. 15: 2768-2776, 1995a.
34. MALMBERG, A. B. AND YAKSH, T. L.: The effect of morphine on formalin-evoked behaviour and spinal release of excitatory amino acids and prostaglandin E2 using microdialysis in conscious rats. Br. J. Pharmacol. 114: 1069-1075, 1995b.
35. MAO, J., PRICE, D. D., HAYES, R. L., LU, J., MAYER, D. J. AND FRENK, H.: Intrathecal treatment with dextrorphan or ketamine potently reduces painrelated behaviors in a rat model of peripheral mononeuropathy. Brain Res. 605: 164-168, 1993.
36. MAX, M. B., BYAS-SMITH, M. G., GRACELY, R. H. AND BENNETT, G. J.: Intravenous infusion of the NMDA antagonist, ketamine, in chronic posttraumatic pain with allodynia: A double-blind comparison to alfentanil and placebo. Clin. Neuropharmacol. 18: 360-368, 1995.
37. MCLACHLAN, E. M., JANIG, W., DEVOR, M. AND MICHAELIS, M.: Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature 363: 543-546, 1993.
38. MCQUAY, H. J., CARROLL, D., JADAD, A. R., GLYNN, C. J., JACK, T., MOORE, R. A. AND WIFFEH, P. J.: Dextromethorphan for the treatment of neuropathic pain: A double-blind randomised controlled crossover trial with integral n-of-1 design. Pain 59: 127-133, 1994.
39. MONYER, H., BURNASHEV, N., LAURIE, D. J., SAKMANN, B. AND SEEBURG, P. H.: Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12: 529-540, 1994.
40. MORON, M. A., STEVENS, C. W. AND YAKSH, T. L.: The antiseizure activity of dihydropyridine calcium channel antagonists in the conscious rat. J. Pharmacol. Exp. Ther. 252: 1150-1155, 1990.
41. NAGY, J. I. AND VAN DER KOOY, D.: Effects of neonatal capsaicin treatment on nociceptive thresholds in the rat. J. Neurosci, 3: 1145-1150, 1983.
42. NEUGEBAUER, V., LUCKE, T. AND SCHAIBLE, H. G.: N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint. J. Neurophysiol. 70: 1365-1377, 1993.
43. PORTER, R. H. AND GREENAMYRE, J. T.: Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. J. Neurochem. 64: 614-623, 1995.
44. REN, K., WILLIAMS, G. M., HYLDEN, J. L., RUDA, M. A. AND DUBNER, R.: The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats. Eur, J. Pharmacol. 219: 235-243, 1992.
45. SHIR, Y. AND SELTZER, Z.: A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neurosci. Lett. 115: 62-67, 1990.
46. SLUKA, K. A. AND WESTLUND, K. N.: An experimental arthritis in rats: dorsal horn aspartate and glutamate increases. Neurosci. Lett. 145: 141-144, 1992.
47. SUGIMOTO, T., BENNETT, G. J. AND KAJANDER, K. C.: Transsynaptic degeneration in the superficial dorsal horn after sciatic nerve injury: Effects of a chronic constriction injury, transection, and strychnine. Pain 42: 205-213, 1990.
48. TALLARIDA, R. J. AND MURRAY, R. B.: Manual of Pharmacologic Calculations with Computer Programs, 2nd, Springer-Verlag, New York, 1987.
49. TOLLE, T. R., BERTHELE, A., ZIEGLGANSBERGER, W., SEEBURG, P. H. AND WISDEN, W.: The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13: 5009-5028, 1993.
50. VALTSCHANOFF, J. G., WEINBERG, R. J. AND RUSTIONI, A.: Amino acid immunoreactivity in corticospinal terminals. Exp. Brain Res. 93: 95-103, 1993.
51. WAHREN, L. K. AND TOREBJÖRK, E.: Quantitative sensory tests in patients with neuralgia 11 to 25 years after injury. Pain 48: 237-244, 1992.
52. WATANABE, M., INOUE, Y., SAKIMURA, K. AND MISHINA, M.: Distinct distributions of five N-methyl-D-aspartate receptor channel subunit mRNAs in the forebrain. J. Comp. Neurol. 338: 377-390, 1993.
53. WATANABE, M., MISHINA, M. AND INOUE, Y.: Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem. J. Comp. Neurol. 343. 520-531, 1994a.
54. WATANABE, M., MISHINA, M. AND INOUE, Y.: Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland. Neurosci. Lett. 165: 183-186, 1994b.
55. WATANABE, M., MISHINA, M. AND INOUE, Y.: Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord. J. Comp. Neurol. 345: 314-319, 1994c.
56. WHEELER-ACETO, H., PORRECA, F. AND COWAN, A.: The rat paw formalin test: Comparison of noxious agents. Pain 40: 229-238, 1990.
57. WOOLF, C. J., SHORTLAND, P. AND COGGESHALL, R. E.: Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355: 75-78, 1992.
58. YAKSH, T. L. AND RUDY, T. A.: Chronic catheterization of the spinal subarachnoid space. Physiol. Behav. 17: 1031-1036, 1976.
59. YAMAMOTO, T. AND YAKSH, T. L.: Comparison of the antinociceptive effects of pre-and posttreatment with intrathecal morphine and MK801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 77: 757-763, 1992a.
60. YAMAMOTO, T. AND YAKSH, T. L.: Spinal pharmacology of thermal hyperesthesia induced by constriction injury of sciatic nerve. Excitatory amino acid antagonists. Pain 49: 121-128, 1992b.
61. YANG, L.-C., MARSALA, M. AND YAKSH, T. L.: Knee joint inflammation in the rat: A potential role of spinal PGE2 and NO release in hypersensitivity state. Anesthesiology 83(3A): A794, 1995.
62. ZHENG, F. AND GALLAGHER, J. P.: Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in dorsolateral septal nucleus (DLSN) neurons. J. Neurosci. 15: 504-510, 1995.