Effects of different PPARγ-agonists on MCP-1 expression and monocyte recruitment in experimental glomerulonephritis

Kidney International

Volumn 62, Issue 2, 2002, Pages 455-464

  Panzer, Ulf ^a,b   Schneider, André ^a,b   Guan, Youfei ^a,b   Reinking, Rüdiger ^a,b   Zahner, Gunther ^a,b   Harendza, Sigrid ^a,b   Wolf, Gunter ^a,b   Thaiss, Friedrich ^a,b   Stahl, Rolf A K ^a,b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

15d PGJ2; Activator protein 1; Ciglitazone; Monocyte chemoattractant protein 1; Nuclear factor B; Peroxisome proliferator activated receptor ; Troglitazone

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; CELL RECEPTOR; CHEMOKINE RECEPTOR; CHROMAN DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MONOCYTE CHEMOATTRACTANT PROTEIN 1 RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; NUCLEAR PROTEIN; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TROGLITAZONE; CHEMOKINE RECEPTOR CCR2; CIGLITAZONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; THIAZOLIDINE DERIVATIVE; THYMOCYTE ANTIBODY;

ANIMAL; ARTICLE; CELL MOTION; CYTOLOGY; DRUG POTENTIATION; GENE EXPRESSION; GENETICS; GLOMERULONEPHRITIS; IMMUNOLOGY; MACROPHAGE; MALE; METABOLISM; MONOCYTE; RAT; WISTAR RAT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL INFILTRATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; IMMUNOHISTOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

ANIMALS; CELL MOVEMENT; CHEMOKINE CCL2; CHROMANS; GENE EXPRESSION; GLOMERULONEPHRITIS; HYPOGLYCEMIC AGENTS; MACROPHAGES; MALE; MONOCYTES; NF-KAPPA B; NUCLEAR PROTEINS; RATS; RATS, WISTAR; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0035992570     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00476.x     Document Type: Article

References (42)

1. The nuclear receptor superfamily: The second decade
2. Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions
3. PPARγ: Adipogenic regulator and thiazolidinedione receptor
4. The nuclear receptor PPARγ bigger than fat
5. PPARγ, the ultimate thrifty gene
6. Antidiabetic drugs present and future: Will improving insulin resistance benefit cardiovascular risk in type 2 diabetes mellitus?
7. Antihypertensive and vasculo- and renoprotective effects of pioglitazone in genetically obese diabetic rats
8. Peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, protects against nephropathy and pancreatic islet abnormalities in Zucker fatty rats
9. Peroxisome proliferator-activated receptor-γ agonist troglitazone protects against nondiabetic glomerulosclerosis in rats
10. PPARγ agonists inhibit production of monocyte inflammatory cytokines
11. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
12. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
13. Activation of peroxisome proliferator-activated receptor γ does not inhibit IL-6 of TNF-α responses of macrophages to lipopolysaccharide in vitro or in vivo
14. Differential regulation of chemokine gene expression by 15-deoxy-Δ 12,14 Prostaglandin J2
15. 15-Deoxy-d12,14-prostaglandin J2 inhibits multiple steps in the NFκB signaling pathway
16. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
17. Chemokines and leukocyte traffic
18. Initial characterization of a peripheral blood mononuclear cell chemoattractant derived from cultured arterial smooth muscle cells
19. Monocyte chemoattractant protein-1 mediates monocyte/macrophage influx in anti-thymocyte antibody-induced glomerulonephritis
20. RANTES and MCP-1 play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis
21. MCP-1 and osteopontin differentially regulate glomerular and tubulointerstitial monocyte recruitment in experimental glomerulonephritis
22. Increased expression of monocyte chemoattractant protein-1 in anti-thymocyte antibody-induced glomerulonephritis
23. The chemokine receptor antagonist AOP-RANTES reduces monocyte infiltration in experimental glomerulonephritis
24. Activation of transcription factor NF-kappa B in experimental glomerulonephritis in rats
25. Expression of peroxisome proliferator-activated receptor gamma (PPARγ) in rat aortic smooth muscle cells
26. Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy
27. Hepatic injury due to troglitazone
28. Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans
29. Expression of peroxisomal proliferator-activated receptors and retinoid X receptors in the kidney
30. Peroxisome proliferator-activated receptor-γ activity is associated with renal microvasculature
31. Advanced glycation end product-induced peroxisome proliferator-activated receptor γ gene expression in cultured mesangial cells
32. Inhibition of mesangial cell nitric oxide in MRL/lpr mice by prostaglandin J2 and proliferator activation receptor-γ agonists
33. A novel therapy for colitis utilizing PPARγ ligands to inhibit the epithelial inflammatory response
34. MCP-1 mediates collagen deposition in experimental glomerulonephritis by stimulation of transforming growth factor β
35. Expression of the chemokine monocyte chemoattractant protein-1 and its receptor chemokine receptor 2 in human crescentic glomerulonephritis
36. High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells
37. Angiotensin III increases MCP-1 and activates NF-kappa B and AP-1 in cultured mesangial and mononuclear cells
38. Effects of prednisolone on glomerular signal transduction cascades in experimental glomerulonephritis
39. 15-deoxy-12,14-prostaglandin J2 and thiazolidinediones activate MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells
40. Cyclopentenone prostaglandins inhibit cytokine-induced NF-κB activation and chemokine production by human mesangial cells
41. Control of vascular cell proliferation and migration by PPAR-gamma: A new approach to the macrovascular complications of diabetes
42. Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: Inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone