The role of interleukin 13 in classical Hodgkin lymphoma

Leukemia and Lymphoma

Volumn 43, Issue 6, 2002, Pages 1203-1210

  Skinnider, Brian F ^a   Kapp, Ursula ^a   Mak, Tak W ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Autocrine growth factor; Hodgkin lymphoma; Interleukin 13; STAT6

Indexed keywords

CYTOKINE; GROWTH FACTOR; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; RECEPTOR SUBTYPE; STAT6 PROTEIN; CHEMOKINE; IL13RA1 PROTEIN, HUMAN; IL13RA1 PROTEIN, MOUSE; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN RECEPTOR; STAT6 PROTEIN, HUMAN; STAT6 PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN; TUMOR PROTEIN;

APOPTOSIS; CANCER TISSUE; CELL CULTURE; CELL PROLIFERATION; CLINICAL FEATURE; CONTROLLED STUDY; DOSE RESPONSE; HODGKIN DISEASE; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IN VIVO STUDY; INFLAMMATORY INFILTRATE; LYMPHOMA CELL LINE; MEDIATOR; NONHODGKIN LYMPHOMA; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REED STERNBERG CELL; REVIEW; SIGNAL TRANSDUCTION; TUMOR BIOPSY; ANIMAL; AUTOCRINE EFFECT; B LYMPHOCYTE; DRUG EFFECT; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE; PHYSIOLOGY; SECRETION; TRANSGENIC MOUSE;

ANIMAL; APOPTOSIS; AUTOCRINE COMMUNICATION; B-LYMPHOCYTES; CHEMOKINES; HODGKIN DISEASE; HUMAN; INFLAMMATION; INTERLEUKIN-13; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-4; REED-STERNBERG CELLS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; ANIMALS; HUMANS; INTERLEUKIN-13 RECEPTOR ALPHA1 SUBUNIT; RECEPTORS, INTERLEUKIN-13; STAT6 TRANSCRIPTION FACTOR;

EID: 0035992266     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/10428190290026259     Document Type: Review

References (44)

1. "Recent results on the biology of Hodgkin and Reed-Sternberg cells. I. Biopsy material"
2. "Recent results on the biology of Hodgkin and Reed-Sternberg cells. II. Continuous cell lines"
3. "Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells"
4. "Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma"
5. "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells"
6. "Differential regulation of IL-13 and IL-4 production by human CD8 + and CD4 + Th0, Th1 and Th2 T cell clones and EBV-transformed B cells"
7. "Activated mast cells produce interleukin 13"
8. "Human blood basophils produce interleukin-13 in response to IgE-receptor-dependent and -independent activation"
9. "Interleukin-2 secretion by human B lymphocytes occurs as a late event and requires additional stimulation after CD40 cross-linking"
10. "Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells"
11. "Interleukin 13, a T-cell derived cytokine that regulates human monocyte and B-cell function"
12. "Interleukin 13 is a B cell stimulating factor"
13. "Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: Upregulation of Bcl-xL and Mcl-1"
14. "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses"
15. "Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes"
16. "The distribution of IL-13 receptor alphal expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4"
17. "Divergent effects of interleukin-4 and interferon-gamma on macrophage-derived chemokine production: An amplification circuit of polarized T helper 2 responses"
18. "STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13"
19. "STAT6 mediates eotaxin-1 expression in IL-4 or TNF-alpha-induced fibroblasts"
20. "Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes"
21. "Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3"
22. "Synergistic effects of interleukin-4 or interleukin-13 and tumor necrosis factor-α on eosinophil activation in vitro"
23. "Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, sub-epithelial fibrosis, physiologic abnormalities, and eotaxin production"
24. "An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response"
25. "The IL-4 receptor: Signaling mechanisms and biologic functions"
26. "cDNA cloning and characterization of the human interleukin 13 receptor α chain"
27. "Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor α chain"
28. "The interleukin-4/interleukin-13 receptor of human synovial fibroblasts: Over-expression of the nonsignaling interleukin-13 receptor alpha2"
29. "The interleukin-13 receptor alpha2 chain: An essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway"
30. "JAKs and STATs: Biological implications"
31. "The biology of Stat4 and Stat6"
32. "Essential role of Stat6 in IL-4 signaling"
33. "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene"
34. "Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice"
35. "Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma"
36. "Interleukin-13 and interleukin-13 receptor in Hodgkin's disease: Possible autocrine mechanism and involvement in fibrosis"
37. "Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin's disease"
38. "Quantitative immunohistochemical analysis of cytokine profiles in Epstein-Barr virus-positive and -negative cases of Hodgkin's disease"
39. "Differential chemokine expression in tissues involved by Hodgkin's disease: Direct correlation of eotaxin expression and tissue eosinophilia"
40. "High expression of the CC chemokine TARC in Reed-Sternberg cells. A possible explanation for the characteristic T-cell infiltrate in Hodgkin's lymphoma"
41. "Hodgkin/Reed-Sternberg cells induce fibroblasts to secrete eotaxin, a potent chemoattractant for T cells and eosinophils"
42. "Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells"
43. "Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation"
44. "A distinct role for interleukin-13 in Th2-cell-mediated immune responses"