LIM-domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated STAT1

Biochemical Journal

Volumn 359, Issue 3, 2001, Pages 485-496

  Weiskirchen, R ^a   Moser, M ^a   Weiskirchen, S ^a   Erdel, M ^a   Dahmen, S ^a   Buettner, R ^a   Gressner, A M ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Bile duct ligation; JAK STAT pathway; LIMdomain proteins; Liver fibrosis; Platelet derived growth factor

Indexed keywords

BIOLOGICAL ORGANS; CELLS; PRECIPITATION (CHEMICAL); SCANNING ELECTRON MICROSCOPY; YEAST;

REGULATORY GENES;

PROTEINS;

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CYSTEINE; PLATELET DERIVED GROWTH FACTOR; PROTEIN INHIBITOR; STAT1 PROTEIN;

ANIMAL CELL; ARTICLE; BILE DUCT LIGATION; CELL DIFFERENTIATION; DNA LIBRARY; ENDOTHELIUM CELL; FIBROBLAST; KUPFFER CELL; LIVER CELL; MYOFIBROBLAST; NONHUMAN; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; STELLATE CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; CHROMOSOME MAPPING; EMBRYO; HEPATOCYTES; HUMANS; IN SITU HYBRIDIZATION; LIVER; LIVER CIRRHOSIS; MALE; MICE; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN INHIBITORS OF ACTIVATED STAT; PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES; ZINC FINGERS;

EID: 0035504489     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3590485     Document Type: Article

References (50)

1. The cysteine-rich protein family of highly related LIM domain proteins
2. Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif
3. Suppression in transformed avian fibroblasts of a gene (crp) encoding a cysteine-rich protein containing LIM domains
4. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation
5. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ
6. Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD
7. Comparison of three members of the cysteine-rich protein family reveals functional conservation and divergent patterns of gene expression
8. Embryonic expression suggest an important role for CRP2/SmLIM in the developing cardiovascular system
9. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure
10. CRP1, a LIM domain protein implicated in muscle differentiation, interacts with α-actinin
11. LIM domains of cysteine-rich protein 1 (CRP1) are essential for the zyxin-binding function
12. The muscle regulatory and structural protein MLP is a cytoskeletal binding partner of β1-spectrin
13. Conditional cell transformation by doxycycline-controlled expression of the MC29 v-myc allele
14. Molecular cloning and characterization of SmLIM, a developmentally regulated LIM protein preferentially expressed in aortic smooth muscle cells
15. Mechanism of action and in vivo role of platelet-derived growth factor
16. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
17. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
18. Signal transduction in hepatic stellate cells
19. Structure of cysteineand glycine-rich protein CRP2: Backbone dynamics reveal motional freedom and independent spatial orientation of the LIM domains
20. Inhibition of Stat1-mediated gene activation by PIAS1
21. Preparation of rat liver cells
22. Purified rat liver fat-storing cells in culture divide and contain collagen
23. The synthesis of proteoglycans in fat-storing cells of rat liver
24. Isolation and characterization of Kupffer and endothelial cells from the rat liver
25. Synergism between hepatocytes and Kupffer cells in the activation of fat storing cells (perisinusoidal lipocytes)
26. Proliferation of fat-storing cells in stimulated by secretions of Kupffer cells from normal and injured liver
27. Prolonged bile duct obstruction: A new experimental model for cirrhosis in the rat
28. Cloning, structural analysis, and chromosomal localization of the human CSRP2 gene encoding the LIM domain protein CRP2
29. Cdil, a human G1 and S-phase protein phosphatase that associates with Cdk2
30. Transformation of intact yeast cells treated with alkali cations
31. High efficiency transformation of intact cells using single stranded nucleic acids as a carrier
32. DMSO-enhance whole cell yeast transformation
33. Improved method for high efficiency transformation of intact yeast cells
34. Interaction trap/two-hybrid system to identify interacting proteins
35. Correlation of two-hybrid affinity data with in vitro measurements
36. Preparation of DNA, RNA, and protein extracts from yeast
37. The cysteine- and glycine-rich LIM domain protein CRP2 specifically interacts with a novel human protein (CRP2BP)
38. 1-integrin
39. Inhibition of platelet-derived growth factor BB-induced expression of glyceraldehyde-3-phosphate dehydrogenase by sodium butyrate in rat vascular smooth muscle cells
40. 4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43
41. Zyxin and cCRP: Two interactive LIM domain proteins associated with the cytoskeleton
42. Understanding gene and allele function with two-hybrid methods
43. Cloning and characterization of Gu/RH-11 binding protein
44. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells
45. Mitogenic signals for platelet-derived growth factor isoforms in liver fat-storing cells
46. Human cysteine-rich protein: A member of the LIM/double-finger family displaying coordinate serum induction with c-myc
47. Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis
48. 2- And COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction
49. Regulation of STAT-dependent pathways by growth factors and cytokines
50. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins