α2-Macroglobulin reduces paracrine- and autocrine-stimulated matrix synthesis of cultured rat hepatic stellate cells

European Journal of Clinical Investigation

Volumn 29, Issue 6, 1999, Pages 519-528

  Schuftan G G ^b   Bachem, M G ^a  

^a UNIVERSITY OF ULM   (Germany)

^b NONE

Author keywords

2 macroglobulin; Fibrogenesis; Hepatic stellate cells; Transforming growth factor

Indexed keywords

ALPHA 2 MACROGLOBULIN; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA1; ANTISENSE OLIGODEOXYNUCLEOTIDE; FIBRONECTIN; SCLEROPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

AGAR GEL ELECTROPHORESIS; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; KUPFFER CELL; LIVER CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; RAT; STELLATE CELL; THROMBOCYTE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; CELL SEPARATION; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; LIVER; METABOLISM; PHYSIOLOGY;

ALPHA-MACROGLOBULINS; ANIMALS; BLOOD PLATELETS; CELL DIVISION; CELL SEPARATION; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; EXTRACELLULAR MATRIX PROTEINS; FIBRONECTINS; GENE EXPRESSION REGULATION; KUPFFER CELLS; LIVER; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEOGLYCANS; RATS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033146135     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.1999.00496.x     Document Type: Article

References (53)

1. 1 Sottrup-Jensen L, Alpha-2-macroglobulins: structure, shape and mechanism of proteinase complex formation. Biol Chem, 1989; 264: 1539-1542.
2. 2 Okubo H, Miyanaga O, Nagano L. Purification and immunulogical determination of alpha-2-macroglobulin in serum from injured rats. Biochim Biophys Acta, 1981; 668: 257-67.
3. 3 Andus T, Ramadori G, Heinrich PC, Knittel T, Meyer-zum-Büschenfelde KH. Cultured Ito cells of rat liver express the alpha-2-macroglobulin gene. Eur J Biochem, 1987; 168: 641-6.
4. 4 Borth W. Alpha-2-macroglobulin, a multifunctional binding protein with targeting characteristics. FASEB J, 1992; 6; 3345-53.
5. 5 Crookston KP, Webb DJ, LaMarre J, Gonias SL, Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations. Biochem J, 1093; 293; 443-50.
6. 6 LaMarre J, Wollenbcrg GK, Gauldie J, Hayes MA. Alpha-2-macroglobulin and serum preferentially counteract the mito-inhibitory effect of transforming growth factor beta-2 in rat hepatocytes. Lab Invest, 1990; 62: 545-51.
7. 7 O'Connor-McCourt MD, Wakefield LM. Latent transforming growth factor beta in serum, A specific complex with alpha-2-macroglobulin. J Biol Chem, 1987; 262: 14090-9.
8. 8 Stouffer GA, LaMarre J, Gonias SL, Owens GK. Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response. J Biol Chem, 1993; 268/24: 18340-1.
9. 2-macroglobulin receptor/low density lipoprotein receptor related protein and the receptor-associated protein: an overview. Ann NY Acad Sci, 1994; 737: 1-13.
10. 2-macroglobulin receptor/LRP. a growth regulatory axis. Ann NY Acad Sci, 1994; 737: 273-90.
11. 2-matroglobulin, J Hepatol, 1997; 26: 1220-8.
12. 12 Czaja MJ, Weiner FR, Flanders KC, et al. In vitro and in vivo association of transforming growth factor-β1 with hepatic fibrosis. J Cell Biol, 1989; 108: 2477-82.
13. 13 Gressner AM, Bachem MG. Molecular mechanisms of liver fibrogenesis-A homage to the role of activated fat-storing cells. Digestion, 1995; 56: 335-46.
14. 14 Casini A, Pinzani M, Milani S, et al. Regulation of extracellular matrix synthesis by transforming growth factor-beta 1 in human fat-storing cells. Gastroenterology, 1993; 105: 245-53.
15. 15 Ignotz RA, Massagué J. Transforming growth factor beta stimulates the expression of fibronectin and collagen and their incorporation into extracellular matrix. J Biol Chem, 1986; 261: 4337-45.
16. 16 Meyer D, Bachem MG, Gressner AM. Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffercell-derived transforming growth factors type beta 1 and type alpha. Biochim Biophys Res Comm, 1990; 171: 1122-9.
17. 17 Bachem MG, Melchior R, Gressner AM. The role of thrombocytcs in liver fibrogenesis: Effects of platelet-lysate and thrombocyte-derived growth factors on the mitogenic activity and glycosaminoglycan synthesis of cultured rat liver fat storing cells. J Clin Chem Clin Biochem, 1989, 27: 555-65.
18. 18 Bachem MG, Riess U, Melchior R, Sell KM, Gressner AM. Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells. FEBS Lett, 1989; 257: 134 -7.
19. 19 Rieder H, Armbrust T, Meyer-zum-Büschenfelde KH, Ramadori G. Contribution of sinusoidal endothelial liver cells to liver fibrosis:Expression of transforming growth factor beta 1 receptors and modulation of plasmin-generating enzymes by transforming growth factor beta 1. Hepatology, 1993; 18: 937-44.
20. 20 Edwards DR, Murphy G, Reynolds JJ. Transforming growth factor beta modulates the expression of metalloproteinase inhibitor. EMBO J, 1987; 6: 1899-904.
21. 21 Friedman SL. The cellular basis of hepatic fibrosis. N Engl J Med, 1993; 328: 1828-35.
22. 22 Knittel T, Schuppan D, Meyer-zum-Büschenfelde KH, Ramadori G. Differential expression of collagen types I III and IV by fat-storing (Ito) cells in vitro. Gastroenterology, 1992; 102: 1724-35.
23. 23 Krull N, Zimermann T, Gressner AM. Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat. Hepatology, 1993; 18: 581-9.
24. 24 Gressner AM, Haarmann R. Hyaluronic acid synthesis and secretion by rat liver fat storing cells perisinusoidal lipocytes in culture, Biochem Biophys Res Commun, 1988; 151: 222-9.
25. 25 Ramadori G, Knittel T, Odenthal M, Schwogler S, Neubauer K, Meyer-zum-Büschenfelde KH. Synthesis of cellular fibronectin by rat liver fat storing (Ito) cells-regulation by cytokines. Gastroenterolgy, 1992; 103: 1313-21.
26. 26 Bachem MG, Riess U, Gressner AM. Liver fat storing cell proliferation is stimulated by EGF/TGF_and inhibited by TGF beta, Biochem Biophys Res Cumm, 1989; 162: 708-14.
27. 27 Bachem MG, Sell KM, Melchior R, Kropf J, Eller T, Gressner AM. Tumor necrosis factor alpha (TNF α) and transforming growth factor b l (TGFβ) stimulate fibronectin synthesis and the transdifferentiation of fat storing cells in the rat liver into myofibroblasts. Virchows Arch B Cell Pathol, 1993; 63: 123-30.
28. 28 Bachem MG, Meyer DM, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells - A potential mechanism of self-perpetuation in liver fibrosis. J Clin Invest, 1992; 89: 19-27.
29. 29 Assoian RK, Komoriya A, Meyers CA, Miller DM, Sporn MB. Transforming growth factor-beta in human platelets: identification of a major storage site, purification and characterization. J Biol Chem, 1983; 258: 7155-60.
30. 30 Quian SW, Kondaiah P, Roberts AB, Sporn MB. cDNA cloning by PCR of rat transforming growth factor β-1. Nucleic Acids Res, 1999; 18: 3059.
31. 31 Stein CA, Subasinghe C, Shinozuka K, Cohen JS 1988 Physicochemical properties of phosphorothioate oligodeoxynucieotides. Nucleic Acids Res 16: 3209-21.
32. 32 Danielpour D, Dart LL, Flanders KC, Roberts AB, Sporn MB. Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-/β1 and TGF-β2) secreted by cells in nature. J Cell Physiol, 1989; 138: 79-86.
33. 33 Labarca C, Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal Biochem, 1980; 102: 344-52.
34. 34 Kropf J, Gressner AM, Kothe M. Development of a sensitive time-resolved immunofluorometric assay for cellular fibronectin (abstract). Lab Med, 1994; 18: 407.
35. 35 Sachs L. Statistische Methoden: Planung und Auswertung, 7th edn. Berlin, Heidelberg, New York: Springer-Verlag; 1993. p. 90-92.
36. 36 Zerbe O, Gressner AM. Proliferation of fat storing cells is stimulated by secretions of Kupffer cells from normal and injured liver. Exp Mol Pathol, 1988; 49: 87-101.
37. 37 Assoian RK, Grotendorst GR, Miller DM, Sporn MB. Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature, 1984; 309: 804-6.
38. 38 Pinzani M, Abboud HE, Aron DC. Secretion of insulin-like growth factor-1 and binding proteins by rat liver fat storing cells: Regulatory role of platelet-derived growth factor. Endocrinology, 1990; 127: 2343-9.
39. 39 McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatits. Hepatology, 1989; 9: 349-51.
40. 40 Attisano L, Wrana JL, Lopez-Casillas F, Massagué J. TGFβ receptors and actions. Biochim Biophys Acta, 1994; 1222: 71 -80.
41. 41 Miyazono K, Ichijo H, Heldin CH. Transforming growth factors-β: latent forms, binding proteins and receptors. Crowth Factors, 1993; 8: 11-22.
42. 42 Dennis PA, Ritkin DB. Cellular activation of latent transforming growth factor β requires binding to the cation -independent mannoseσ-phosphat/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA, 1991; 88: 580-94.
43. 43 Flaumenhaft R, Abe M, Sato Y, et al. Role of the latent TGFβ binding protein in the activation of latent TGFβ by co-cultures of endothelial and smooth muscle cells. J Cell Biol, 1993, 120: 995-1002,
44. 44 Okuno M, Morikawi H, Imai S, et al. Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-β in liver stellate cells. Hepatology, 1997; 26: 913-21.
45. 45 Bachem MG, Sell KM, Schüftan G, et al. Cooperation of fat-storing cells, Kupffer cells and platelets with endothelial cells in TGFβ-activation, In: Wisse E, Knook DL, Wake K, editors, Cells of the hepatic sinusoid, Vol. 5. Leiden: The Kupffer Cell Foundation; 1995. p, 416-17.
46. 46 de Bleser PJ, Jannes P, van Buul-Offers SC, et al, Insulinlike growth factor-II/mannose 6-phosphate receptor is expressed on CC14-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-β in cocultures with sinusoidal endothelial cells. Hepatology, 1995; 21: 1429-37.
47. 47 Wollenberg GK, LaMarre J, Rosendal S, Gonias SL, Hayes MA. Binding of tumor necrosis factor alpha to activated forms of human plasma alpha-2-macroglobulin. Am J Pathol, 1991, 138: 265-72.
48. 2-macroglobulin-trypsin complex in the rat is mainly accounted for by uptake into hepatocytes. Biochim Biophys Acta, 1985; 846: 85-92.
49. 2MR, and the receptor-associated protein (RAP). J Histochem Cytochem, 1994; 42/4: 531-42.
50. 1. Its putative role in liver fibrogenesis. In: Knook DL, Wisse E., editors. Cells of the hepatic sinusoid, Vol. 4. Leiden: The Kupffer Cell Foundation; 1993. p. 218-21.
51. 51 Herz J, Goldstein JL, Strickland DK, Ho YK, Brown MS. 39 kDa protein modulates binding of ligands to low densitiy lipoprotein receptor related protein/alpha-2-macroglobulin receptor. J Biol Chem, 1991; 266: 21232-8.
52. 2-macroglobulin and apolipoprotein E gene expression in cultured rat liver fat-storing (Ito) cells. Hepatology, 1991; 14: 875-82.
53. 53 Barret AJ. Alpha-2-macroglobulin. Methods Enzymol, 1981; 80: 737-54.