Regulation of the MDR1 gene by transcription repressors selected using peptide combinatorial libraries

Molecular Pharmacology

Volumn 58, Issue 1, 2000, Pages 1-10

  Bartsevich, Victor V ^a   Juliano, R L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN K 562; FLOW CYTOMETRY; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; MULTIDRUG RESISTANCE; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROMOTER REGION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

EID: 0033917833     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.1.1     Document Type: Article

References (42)

1. Alahari SK, Dean NM, Fisher MH, DeLong R, Manoharan M, Tivel KL and Juliano RL (1996) Inhibition of expression of the multidrug resistance-associated P-glycoprotein by phosphorothioate and 5′ cholesterol-conjugated phosphorothioate antisense oligonucleotides. Mol Pharmacol 50:808-819.
2. Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I and Gottesman MM (1999) Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361-398.
3. Beerli RR, Segal DJ, Dreier B and Barbas CF III (1998) Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci USA 95:14628-4633.
4. 1 gene promoter. J Biol Chem 266:20544-20549.
5. Bradley G and Ling V (1994) P-glycoprotein, multidrug resistance and tumor progression. Cancer Metastasis Rev 13:223-233.
6. 1-integrin gene expression is regulated by two promoter regions. J Biol Chem 268:5148-5155.
7. Cheng X, Boyer JL and Juliano RL (1997) Selection of peptides that functionally replace a zinc finger in the Sp1 transcription factor by using a yeast combinatorial library. Proc Natl Acad Sci USA 94:14120-14125.
8. Choo Y, Castellanos A, Garcia-Hernandez B, Sanchez-Garcia I and Klug A (1997) Promoter-specific activation of gene expression directed by bacteriophage-selected zinc fingers. J Mol Biol 273:525-532.
9. Choo Y and Klug A (1994) Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage [published erratum appears in Proc Natl Acad Sci USA (1995) 92:646]. Proc Natl Acad Sci USA 91:11163-11167.
10. Choo Y and Klug A (1994) Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage [published erratum appears in Proc Natl Acad Sci USA (1995) 92:646]. Proc Natl Acad Sci USA 91:11163-11167.
11. Choo Y, Sanchez-Garcia I and Klug A (1994) In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature (Lond) 372:642-645.
12. Christy BA, Lau LF and Nathans D (1988) A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc Natl Acad Sci USA 85:7857-861.
13. Cornwell MM and Smith DE (1993) A signal transduction pathway for activation of the mdr1 promoter involves the proto-oncogene c-raf kinase. J Biol Chem 268: 15347-15350.
14. Elrod-Erickson M, Rould MA, Nekludova L and Pabo CO (1996) Zif268 protein-DNA complex refined at 1.6 A: A model system for understanding zinc finger-DNA interactions. Structure 4:1171-1180.
15. Fairall L, Schwabe JW, Chapman L, Finch JT and Rhodes D (1993) The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition. Nature (Lond) 366:483-487.
16. Greisman HA and Pabo CO (1997) A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science (Wash DC) 275:657-661.
17. Isalan M, Klug A and Choo Y (1998) Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers. Biochemistry 37:12026-12033.
18. Jamieson AC, Kim SH and Wells JA (1994) In vitro selection of zinc fingers with altered DNA-binding specificity. Biochemistry 33:5689-5695.
19. Kadonaga JT (1998) Eukaryotic transcription: An interlaced network of transcription factors and chromatin-modifying machines. Cell 92:307-313.
20. Kadonaga JT, Carner KR, Masiarz FR and Tjian R (1987) Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079-1090.
21. Kim JS and Pabo CO (1997) Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy. J Biol Chem 272:29795-29800.
22. Kim JS and Pabo CO (1998) Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants. Proc Natl Acad Sci USA 95: 2812-2817.
23. Liu Q, Segal DJ, Ghiara JB and Barbas CF III (1997) Design of polydactyl zinc-finger proteins for unique addressing within complex genomes. Proc Natl Acad Sci USA 94:5525-5530.
24. McCoy C, McGee SB and Cornwell MM (1999) The Wilms' tumor suppressor, WT1, inhibits 12-O-tetradecanoylphorbol-13-acetate activation of the multidrug resistance-1 promoter. Cell Growth Differ 10:377-386.
25. McCoy C, Smith DS and Cornwell MM (1995) 12-O-tetradecanoylphorbol-13-acetate activation of the MDR1 promoter is mediated by EGR1. Mol Cell Biol 15:6100-6108.
26. Nagahara H, Vocero-Akbani AM, Snyder EL, Ho A, Latham DG, Lissy NA, Becker-Hapak M, Ezhevsky SA and Dowdy SF (1998) Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat Med 4:1449-1452.
27. Pavletich NP and Pabo CO (1991) Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A. Science (Wash DC) 252:809-817.
28. Pavletich NP and Pabo CO (1993) Crystal structure of a five-finger GLI-DNA complex: New perspectives on zinc fingers. Science (Wash DC) 261:1701-1707.
29. Pengue G and Lania L (1996) Kruppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements. Proc Natl Acad Sci USA 93:1015-1020.
30. Rebar EJ and Pabo CO (1994) Zinc finger phage: Affinity selection of fingers with new DNA-binding specificities. Science (Wash DC) 263:671-673.
31. Roninson IB (1992) The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol 43:95-102.
32. Ruben S, Perkins A, Purcell R, Joung K, Sia R, Burghoff R, Haseltine WA and Rosen CA (1989) Structural and functional characterization of human immunodeficiency virus tat protein. J Virol 63:1-8.
33. Shen DW, Cardarelli C, Hwang J, Cornwell M, Richert N, Ishii S, Pastan I and Gottesman MM (1986) Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. J Biol Chem 261:7762-7770.
34. Sheridan PL, Mayall TP, Verdin E and Jones KA (1997) Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Genes Dev 11:3327-3340.
35. Sikorski RS and Hieter P (1989) A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
36. Triezenberg SJ, Kingsbury RC and McKnight SL (1988) Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression. Genes Dev 2:718-729.
37. Verma IM and Somia N (1997) Gene therapy - Promises, problems and prospects. Nature (Lond) 389:239-242.
38. Wang MM and Reed RR (1993) Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast. Nature (Lond) 364:121-126.
39. West RW Jr, Yocum RR and Ptashne M (1984) Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: Location and function of the upstream activating sequence UASG. Mol Cell Biol 4:2467-2478.
40. Witzgall R, O'Leary E, Leaf A, Onaldi D and Bonventre JV (1994) The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci USA 91:4514-4518.
41. Wolfe SA, Greisman HA, Ramm EI and Pabo CO (1999) Analysis of zinc fingers optimized via phage display: Evaluating the utility of a recognition code. J Mol Biol 285:1917-1934.
42. Wu H, Yang WP and Barbas CF III (1995) Building zinc fingers by selection: Toward a therapeutic application. Proc Natl Acad Sci USA 92:344-348.