NF-κB inhibition enhances peroxynitrite-induced enterocyte apoptosis

Journal of Surgical Research

Volumn 106, Issue 1, 2002, Pages 7-14

  Potoka, Douglas A ^a   Upperman, Jeffrey S ^a   Nadler, Evan P ^a   Wong, Catarina T ^a   Zhou, Xin ^a   Zhang, Xiao Ru ^a   Ford, Henri R ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Apoptosis; Caspases; Enterocyte; Inhibitor of apoptosis proteins; NF B; Peroxynitrite

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; FLUORESCEIN ISOTHIOCYANATE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; LIPOCORTIN 5; MUTANT PROTEIN; NITRIC OXIDE; PEROXYNITRITE; PROPIDIUM IODIDE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; CASPASE; PEROXYNITROUS ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; EPITHELIUM CELL; FLOW CYTOMETRY; GENETIC TRANSFECTION; INTESTINE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; REGULATORY MECHANISM; STAINING; ADENOVIRUS; ANIMAL; CELL LINE; CYTOLOGY; GENE VECTOR; GENETICS; INTESTINE MUCOSA; LACTOSE OPERON; METABOLISM; PHYSIOLOGY; RAT;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CASPASES; CELL LINE; ENTEROCYTES; GENETIC VECTORS; I-KAPPA B PROTEINS; INTESTINAL MUCOSA; LAC OPERON; NF-KAPPA B; PEROXYNITROUS ACID; RATS; TRANSFECTION;

EID: 0035983816     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.2002.6423     Document Type: Article

References (51)

1. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis
2. Increased nitric oxide synthesis in ulcerative colitis
3. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease
4. Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease
5. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: Effect of antibiotics and antioxidants
6. Expression of inducible nitric oxide synthase mRNA in rat digestive tissues after endotoxin and its role in intestinal mucosal injury
7. Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats
8. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
9. Inhibition of nitric oxide with aminoguanidine reduces bacterial translocation after endotoxin challenge in vivo
10. Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease
11. Peroxynitrite-induced apoptosis in HL-60 cells
12. Peroxynitrite-induced apoptosis in T84 and RAW 264.7 cells: Attenuation by L-ascorbic acid
13. Peroxynitrite-induced cytotoxicity in PC12 cells: Evidence for an apoptotic mechanism differentially modulated by neurotrophic factors
14. Mitochondria and apoptosis
15. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition
16. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
17. Role of NF-κB in immune and inflammatory responses in the gut
18. Function and activation of NF-kappa B in the immune system
19. Nuclear factor-κB is activated in intestinal mucosa during endotoxemia
20. Nuclear factor κB is activated in macrophages and epithelial cells of inflamed intestinal mucosa
21. Cytokine-induced intestinal epithelial hyperpermeability: Role of nitric oxide
22. Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29
23. Modulation of cellular phospholipid fatty acids and leukotriene B4 synthesis in the human intestinal cell (CaCo-2)
24. Differential cytokine expression by human intestinal epithelial cell lines: Regulated expression of interleukin 8
25. A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion
26. Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines
27. Evidence for function of Ia molecules on gut epithelial cells in man
28. An essential role for NF-κB in preventing TNF-α-induced cell death
29. Suppression of TNF-α-induced apoptosis by NF-κB
30. Cloning of human Bcl-2 homologue: Inflammatory cytokines induce human A1 in cultured endothelial cells
31. Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
32. The inhibitors of apoptosis (IAPs) and their emerging role in cancer
33. Inhibition of NF-κB by IκB prevents cytokine-induced NO production and promotes enterocyte apoptosis in vitro
34. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V
35. Sequence-specific interactions of nuclear factors with the insulin gene enhancer
36. Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species
37. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
38. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor κB super-repressor in human intestinal epithelial cells
39. Mechanistic aspects of NF-kappa B regulation: The emerging role of phosphorylation and proteolysis
40. Control of IκB-alpha proteolysis by site-specific, signal-induced phosphorylation
41. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB
42. Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-kappa B
43. Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis
44. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
45. X-linked IAP is a direct inhibitor of cell-death proteases
46. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
47. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
48. IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling
49. Multiple redox regulation in NF-kappaB transcription factor activation
50. Interleukin-1 beta induces nuclear factor kappa B in epithelial cells independently of the production of reactive oxygen intermediates
51. Distinct signal transduction pathways mediate nuclear factor-kappaB induction by IL-1beta in epithelial and lymphoid cells