Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 8, 1999, Pages 1167-1170

  Carter, Jeffery S ^a   Rogier, D J ^a   Graneto, Matthew J ^a   Seibert, Karen ^a   Koboldt, Carol M ^a   Zhang, Yan ^a   Talley, John J ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTACYCLIN DERIVATIVE; SULFONYLUREA DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; INFLAMMATION; POLYMERIZATION; PROSTAGLANDIN SYNTHESIS INHIBITION; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ANIMALS; CYCLOOXYGENASE 2; INHIBITORY CONCENTRATION 50; ISOENZYMES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; SULFONES; THIAZOLES;

EID: 0033583468     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00158-4     Document Type: Article

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