The putative OP4 antagonist, [Nphe1]nociceptin(1-13)NH2, prevents the effects of nociceptin in neuropathic rats

Brain Research

Volumn 905, Issue 1-2, 2001, Pages 127-133

  Corradini, Laura ^a   Briscini, Luca ^a   Ongini, Ennio ^a   Bertorelli, Rosalia ^a  

^a San Raffaele Science Park   (Italy)

Author keywords

Gabapentin; Intrathecal; Mechanical allodynia; Morphine; Nociceptin; Spinal cord; Nphe1 nociceptin(1 13)NH2

Indexed keywords

DELTA OPIATE RECEPTOR; MORPHINE; NOCICEPTIN; NOCICEPTIN(1-13)AMMONIA NPHE 1; OPIATE ANTAGONIST; OPIATE RECEPTOR; OPIATE RECEPTOR 4; PSEUDOPEPTIDE; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; MALE; NERVE INJURY; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE;

ACETIC ACIDS; AMINES; ANALGESICS; ANIMALS; CYCLOHEXANECARBOXYLIC ACIDS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; MALE; MORPHINE; NARCOTICS; NEURALGIA; OPIOID PEPTIDES; PAIN THRESHOLD; PEPTIDE FRAGMENTS; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; SCIATIC NERVE; SPINAL CORD;

EID: 0035968067     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02520-3     Document Type: Article

References (36)

1. Effects of gabapentin on the different components of peripheral and central neuropathic pain syndromes: A pilot study
2. Behavioural evidence that systemic morphine may modulate a phasic pain-related behaviour in a rat model of peripheral mononeuropathy
3. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
4. Nociceptin and the ORL-1 ligand [Phe1ψ(CH2-NH)Gly2]nociceptin(1-13)NH2 exert anti-opioid effects in the Freund's adjuvant-induced arthritic rat model of chronic pain
5. In vitro characterization of J-113397, a non-peptide nociceptin/orphanin FQ receptor antagonist
6. Characterization of [Nphe1]nociceptin(1-13)NH(2), a new selective nociceptin receptor antagonist
7. Orphanin FQ/nociceptin: A role in pain and analgesia, but so much more
8. Temporal changes in spinal cord expression of mRNA for substance P, dynorphin and enkephalin in a model of chronic pain
9. Are opioids effective in relieving neuropathic pain?
10. Reorganization of the spinal dorsal horn in models of chronic pain: Correlation with behaviour
11. Further studies on nociceptin-related peptides: Discovery of a new chemical template with antagonist activity on the nociceptin receptor
12. The new approach to opioid receptors
13. Anti-hyperalgesic and anti-allodynic effects of intrathecal nociceptin/orphanin FQ in rats after spinal cord injury, peripheral nerve injury and inflammation
14. Characterization of nociceptin hyperalgesia and allodynia in conscious mice
15. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain
16. Comparison of three rodent neuropathic pain models
17. Differential expression of galanin immunoreactivities in the primary sensory neurons following partial and complete sciatic nerve injuries
18. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
19. Orphanin FQ is a functional anti-opioid peptide
20. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization
21. In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist
22. A potent and highly selective nonpeptidyl nociceptin/orphanin FQ receptor (ORL1) antagonist: J-113397
23. Intrathecal ketorolac tromethamine produces analgesia after chronic constriction injury of sciatic nerve in rat
24. Orphanin FQ: A neuropeptide that activates an opioidlike G protein-coupled receptor
25. Lumbar catheterization of the spinal subarachnoid space in the rat
26. The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury
27. The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain
28. Orphanin-FQ/nociceptin: Lack of antinociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats
29. Effects of orphanin FQ on endomorphin-1 induced analgesia
30. Neuropathic pain: Aetiology, symptoms, mechanisms, and management
31. Effects of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, and N-methyl-d-aspartate receptor antagonists on the thermal hyperalgesia induced by partial sciatic nerve injury in the rat
32. Effects of intrathecally administered nociceptin, an opioid receptor-like1 (ORL1) receptor agonist, on the thermal hyperalgesia induced by unilateral constriction injury to the sciatic nerve in the rat
33. Nociceptin/orphanin FQ: Role in nociceptive information processing
34. Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat
35. The development of morphine tolerance and dependence in rats with chronic pain
36. An interaction of opioids and galanin in dorsal horn of the spinal cord in mononeuropathic rats