The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain

Pain

Volumn 80, Issue 1-2, 1999, Pages 215-228

  Suzuki, Rie ^a   Chapman, Victoria ^a   Dickenson, Anthony H ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Electrophysiology; Morphine; Nerve injury; Neuropathic pain; Spinal cord; Spinal nerve ligation

Indexed keywords

MORPHINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; INTRATHECAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NERVE CELL; NERVE FIBER C; NERVE INJURY; NEURALGIA; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; INJECTIONS, SPINAL; LIGATION; MALE; MORPHINE; NERVE FIBERS; NEURONS; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL NERVES;

EID: 0033060827     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00208-5     Document Type: Article

References (50)

1. Arner, S. and Meyerson, B.A., Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain, Pain, 33 (1988) 11-23.
2. Attal, N., Jazat, F., Kayser, V. and Guilbaud, G., Further evidence for 'pain-related' behaviours in a model of unilateral peripheral mononeuropathy, Pain, 41 (1990) 235-251.
3. Backonja, M.-M., Miletic, G. and Miletic, V., The effect of continuous morphine analgesia or chronic thermal hyperalgesia due to sciatic constriction injury in rats, Neurosci. Lett., 196 (1995) 61-64.
4. Bennett, G.J. and Xie, Y.K., A peripheral mononeuropathy in the rat that produces disorders of pain sensation like those seen in man, Pain, 33 (1988) 87-107.
5. Besse, D., Lombard, M.C., Zajac, J.M., Roques, B.P. and Besson, J.M., Pre- and post-synaptic distribution of mu, delta and kappa opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord, Brain Res., 521 (1990) 15-22.
6. Besse, D., Lombard, M.C., Perrot, S. and Besson, J.M., Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: comparison with sciatic nerve section and lumbar dorsal rhizotomy, Neuroscience, 50 (1992) 921-933.
7. Bian, D., Nichols, M.L., Ossipov, M.H., Lai, J. and Porreca, F., Characterization of the antiallodynic efficacy of morphine in a model of neuropathic pain in rats, NeuroReport, (1995) 1981-1984.
8. Burchiel, K.J., Spontaneous impulse generation in normal and denervated dorsal root ganglia: sensitivity to alpha-adrenergic stimulation and hypoxia, Exp. Neurol., 85 (1984) 257-272.
9. Chapman, V., Suzuki, R. and Dickenson, A.H., Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-6, J. Physiol., 507(3) (1998a) 881-894.
10. Chapman, V., Suzuki, R., Chamarette, H.L.C., Rygh, L.J. and Dickenson, A.H., Effects of systemic carbamazepine and gabapentin on spinal neuronal response in spinal nerve ligated rats, Pain, 75 (1998b) 261-272.
11. Choi, Y., Yoon, Y.W., Na, H.S., Kim, S.H. and Chung, J.M., Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain, Pain, 59 (1994) 369-376.
12. Chung, K., Kim, H.J., Na, H.S., Park, M.J. and Chung, J.M., Abnormalities of sympathetic innervation in the area of an injured peripheral nerve in a rat model of neuropathic pain, Neurosci. Lett., 162 (1993) 85-88.
13. Chung, K., Lee, B.H., Yoon, Y.W. and Chung, J.M., Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model, J. Comp. Neurol., 376 (1996) 241-252.
14. Desmeules, J.A., Kayser, V., Weil-Fuggaza, J., Bertrand, A. and Guilbaud, G., Influence of the sympathetic nervous system in the development of abnormal pain-related behaviours in a rat model of neuropathic pain, Neuroscience, 67 (1995) 941-951.
15. Dickenson, A.H. and Sullivan, A.F., Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn, Pain, 24 (1986) 211-222.
16. Dickenson, A.H., Where and how do opioids act? In: G.F. Gebhart, D.L. Hammond and T.S. Jensen (Eds.), Progress in Pain Research and Management, Vol. 2, Proceeding of the 7th World Congress on Pain, IASP Press, Seattle, WA, 1994, pp. 525-552.
17. Dubner, R., Neural basis of persistent pain: sensory specialization, sensory modulation and neuronal plasticity. In: T.S. Jensen, J.A. Turner and Z. Wiesenfeld-Hallin (Eds.), Progress in Pain Research and Management, Vol. 8, Proceedings of the 8th World Congress on Pain, IASP Press, Seattle, WA, 1997, pp. 243-257.
18. Fields, H.L. and Rowbotham, M.C., Multiple mechanisms of neuropathic pain: a clinical perspective. In: G.F. Gebhart, D.L. Hammond and T.S. Jensen (Eds.), Progress in Pain Research and Management, Vol. 2, Proceedings of the 7th World Congress on Pain, IASP Press, Seattle, WA, 1994, pp. 437-454.
19. Hedley, L.R., Martin, B., Waterbury, L.D., Clarke, D.E. and Hunter, J.C., A comparison of the action of mexiletine and morphine in rodent models of acute and chronic pain, Proc. West. Pharmacol. Soc., 38 (1995) 103-104.
20. Jadad, A.R., Carroll, D., Glynn, C.J., Moore, R.A. and McQuay, H.J., Morphine responsiveness of chronic pain: double-blind randomized crossover study with patient-controlled analgesia, Lancet, 339 (1992) 1367-1371.
21. Jazat, F. and Guilbaud, G., The 'tonic' pain-related behaviour seen in mononeuropathic rats is modulated by morphine and naloxone, Pain, 44 (1991) 97-102.
22. Kajander, K.C., Wakisaka, S. and Bennett, G.J., Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat, Neurosci. Lett., 138 (1992) 225-228.
23. Kayser, V., Lee, S.H. and Guilbaud, G., Evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in rats with peripheral mononeuropathy, Neuroscience, 64 (1995) 537-545.
24. Kim, S.H. and Chung, J.M., An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain, 50 (1992) 355-363.
25. Kim, J.K., Yoon, Y.W. and Chung, J.M., Comparison of three rodent neuropathic pain models, Exp. Brain Res., 113 (1997) 200-206.
26. Koch, B.D., Faurot, G.F., McGuirk, J.R., Clarke, D.E. and Hunter, J.C., Modulation of mechano-hyperalgesia by clinically effective analgesics in rats with a peripheral mononeuropathy, Analgesia, 2 (1996) 157-164.
27. Laird, J.M.A. and Bennett, G.J., An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy, J. Neurophysiol., 69 (1993) 1-14.
28. Lee, S.H., Kayser, V., Desmeules, J. and Guildbaud, G., Differential action of morphine and various opioid agonists on thermal allodynia and hyperalgesia in mononeuropathic rats, Pain, 57 (1994) 233-240.
29. Lee, Y.-W., Chaplan, S.R. and Yaksh, T.L., Systemic and supraspinal, but not spinal opiates suppress allodynia in a rat neuropathic pain model, Neurosci. Lett., 186 (1995) 111-114.
30. Lombard, M.C. and Besson, J.M., Attempts to gauge the relative importance of pre- and post-synaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord, Pain, 37 (1989) 335-345.
31. Mansour, A., Fox, C.A., Thompson, R.C., Akil, H. and Watson, S.J., Muopioid receptor mRNA expression in the rat CNS: comparison to mureceptor binding, Brain Res., 643 (1994) 245-265.
32. Mao, J., Price, D.D. and Mayer, D.J., Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanism; involved in morphine tolerance and neuropathic pain, Pain, 61 (1995) 353-364.
33. Matos, F.F., Rollema, H., Taiwo, Y.O., Levine, J.D. and Basbaum, A.I., Relationship between analgesia and extracellular morphine in brain and spinal cord in awake rats, Brain Res., 693 (1995) 187-195.
34. Nichols, M.L., Bian, D., Ossipov, M.H., Lai, J. and Porreca, F., Regulation of antiallodynic efficacy by CCK in a model of neuropathic pain in rats, J. Pharmacol. Exp. Ther., 275 (1995) 1339-1345.
35. Ossipov, M.H., Lopez, Y., Nichols, M.L., Bian, D. and Porreca, F., The loss of antinociceptive efficacy of spinal morphine in rats with nerve ligation injury is prevented by reducing spinal afferent drive, Neurosci. Lett., 199 (1995a) 87-90.
36. Ossipov, M.H., Lopez, Y., Nichols, M.L., Bian, D. and Porreca, F., Inhibition by spinal morphine of the tail-flick response is attenuated in rats with nerve ligation injury, Neurosci. Lett., 199 (1995b) 83-86.
37. Palacek, J., Dougherty, P.M., Kim, S.H., Paleckova, V., Lekan, H., Chung, J.M., Carlton, S.M. and Willis, W.D., Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates, J. Neurophysiol., 68 (1992) 1951-1966.
38. Portenoy, R.K., Foley, K.M. and Inturrisi, C.E., The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions, Pain, 43 (1990) 273-286.
39. Rowbotham, M.C., Reisner, L.M. and Fields, H.L., Both intravenous lidocaine and morphine reduce the pain of post-herpetic neuralgia, Neurology, 41 (1991) 1024-1028.
40. Schouenborg, J. and Sjolund, B.H., Activity evoked by A- and C-afferent fibres in rat dorsal horn and its relation to a flexion reflex, J. Neurophysiol., 50 (1983) 1108-1121.
41. Seltzer, Z., Dubner, R. and Shir, Y., A novel model of neuropathic pain disorders produced in rats by partial sciatic nerve injury, Pain, 43 (1990) 205-218.
42. Sheen, K. and Chung, J.M., Signs of neuropathic pain depend on signals from injured nerve fibres in a rat model, Brain Res., 610 (1993) 62-68.
43. Stanfa, L., Dickenson, A.M., Xu, X.-J. and Weisenfeld-Hallin, Z., CCK and morphine analgesia, Trends Pharmacol. Sci., 15 (1994) 65-66.
44. Stevens, C.W., Kajander, K.C., Bennett, G.J. and Seybold, V.S., Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy, Pain, 46 (1991) 315-326.
45. Wall, P.D. and Devor, M., Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats, Pain, 17 (1983) 321-329.
46. Wegert, S., Ossipov, M.H., Nichols, M.L., Bian, D., Vanderah, T.W., Malan, T.P. Jr. and Porreca, F., Differential activities of intrathecal MK-801 or morphine to alter responses to thermal and mechanical stimuli in normal or nerve-injured rats, Pain, 71 (1997) 57-64.
47. Xu, X.-J., Puke, M.J.C., Verge, V.M.K., Wiesenfeld-Hallin, Z., Hughes, J. and Hokfelt, T., Up-regulation of CCK in primary sensory neurons is associated with morphine insensitivity in experimental neuropathic pain in the rat, Neurosci. Lett., 152 (1993) 129-132.
48. Yamamoto, T. and Yaksh, T.L., Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and non-opioid receptor, Anesthesiology, 72 (1991) 817-826.
49. Yu, W., Hao, J.-X., Xu, X.-J. and Wiesenfeld-Hallin, Z., Comparison of the anti-allodynic and antinociceptive effects of systemic, intrathecal and intracerebroventricular morphine in a rat model of central neuropathic pain, Eur. J. Pain, 1 (1997) 17-29.
50. Zimmermann, M., Ethical guidelines for investigations of experimental pain in conscious animals, Pain, 16 (1983) 109-110.