Preclinical drug development paradigms for chemopreventives

Hematology/Oncology Clinics of North America

Volumn 12, Issue 5, 1998, Pages 943-961

  Steele, V E ^a   Boone, C W ^a   Lubet, R A ^a   Crowell, J A ^a   Holmes, C A ^a   Sigman, C C ^a   Kelloff, G J ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; ARACHIDONIC ACID; AZOXYMETHANE; DIETHYLNITROSAMINE; EFLORNITHINE; ENZYME INHIBITOR; FENRETINIDE; GLUTATHIONE TRANSFERASE; METHYLAZOXYMETHANOL; METHYLNITROSOUREA; NATURAL PRODUCT; ORNITHINE DECARBOXYLASE; PIROXICAM; PROTEIN KINASE C; TAMOXIFEN;

ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; BIOASSAY; CANCER PREVENTION; CHEMOPROPHYLAXIS; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SAFETY; DRUG SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

EID: 0031717231     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8588(05)70035-6     Document Type: Article

References (107)

1. T. Akiyama J. Ishida S. Nakagawa Genistein: A specific inhibitor of tyrosine-specific protein kinases J Biol Chem 262 1987 5592 5595
2. J.T. Arnold B.P. Wilkinson S. Sharma Evaluation of chemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay Cancer Res 55 1995 537 543
3. B.M. Babior R.S. Kipnes J.T. Curnutte Biological defense mechanisms: The production by leukocytes of superoxide, a potential bactericidal agent J Clin Invest 52 1973 741 744
4. M.R. Banerjee B.G. Wood L.L. Washburn Brief communication: Chemical carcinogen-induced alveolar nodules in organ culture of mouse mammary gland J Natl Cancer Inst 53 1974 1387 1389
5. P.J. Becci H.J. Thompson J.M. Strum N-butyl-N-(4-hyroxybutyl)nitrosamine-induced urinary bladder cancer in C57BL/6 × DBA/2F1 mice as a useful model for study of chemoprevention of cancer with retinoids Cancer Res 41 1981 927 932
6. H.A. Bern S. Nandi Recent studies of the hormonal influence in mouse mammary tumorigenesis Prog Exp Tumor Res 2 1961 90 144
7. B. Bertram E. Frei M. Wiessler Influence of disulfiram on glutathione-s-transferase, and on nitrosamine-dealkylases of liver, kidney and esophagus of the rat Biochem Pharmacol 34 1985 387 388
8. J.S. Bertram Cancer prevention by carotenoids. Mechanistic studies in cultured cells Ann N Y Acad Sci 691 1993 177 191
9. J.S. Bertram L.N. Kolonel F.L. Meyskens Rationale and strategies for chemoprevention of cancer in humans Cancer Res 47 1987 3012 3031
10. S.P. Bessman C.L. Carpenter The creatine-creatine phosphate energy shuttle Annu Rev Biochem 54 1985 831 862
11. R.P. Bird Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findings Cancer Lett 37 1987 147 151
12. W.J. Blot J.-Y. Li P.R. Taylor Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population J Natl Cancer Inst 85 1993 1483 1492
13. C.W. Boone G.J. Kelloff W.E. Malone Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinical trials: A review Cancer Res 50 1990 2 9
14. C. Borek W.F. Morgan A. Ong Inhibition of malignant transformation in vitro by inhibitors of poly(ADP-ribose) synthesis Proc Natl Acad Sci USA 81 1984 243 247
15. G.W. Carter P.R. Young D.H. Albert 5-Lipoxygenase inhibitory activity of zileuton J Pharmacol Exp Ther 256 1991 929 937
16. N.H. Colburn W.F.V. Bruegge J.R. Bates Correlation of anchorage-independant growth with tumorigenicity of chemically transformed mouse epidermal cells Cancer Res 38 1978 624 634
17. N.H. Colburn B.F. Former K.A. Nelson Tumour promoter induces anchorage independence irreversibly Nature 281 1979 589 591
18. N.H. Colburn S. Ozanne U. Lichti Retinoids inhibit promoter-dependent preneoplastic progression in mouse epidermal cell lines Ann N Y Acad Sci 359 1981 251 259
19. M.M. Compton A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome Cancer Metastasis Rev 11 1992 105 119
20. R.A. Copeland J.M. Williams J. Giannaras Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase Proc Natl Acad Sci USA 91 1994 11202 11206
21. D. Crawford I. Zbinden P. Amstad Oxidant stress induces the proto-oncogenes c-fos and c-myc in mouse epidermal cells Oncogene 3 1988 27 32
22. S. De Flora C.F. Cesarone R.M. Balansky Chemopreventive properties and mechanisms of N-acetylcysteine. The experimental background J Cell Biochem 22 1995 33 41
23. J. DiGiovanni Multistage carcinogenesis in mouse skin Pharmacol Ther 54 1992 63 128
24. K. El-Bayoumy P. Upadhyaya Y.-H. Chae Chemoprevention of cancer by organoselenium compounds J Cell Biochem 22 1995 92 100
25. E. Elmore C. Sun H.-R. Lui Comparison of growth inhibition and involucrin expression in human epithelial cells as endpoints for screening cancer chemopreventive agents in vitro In Vitro Cell Dev Biol Anim 32 1996 63
26. S.M. Fischer L.M. Adams Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism Cancer Res 45 1985 3130 3136
27. S.M. Fischer J.K. Baldwin L.M. Adams Effects of anti-promoters and strain of mouse on tumor promoter-induced oxidants in murine epidermal cells Carcinogenesis 7 1986 915 918
28. J.K. Gierse S.D. Hauser D.P. Creely Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase Biochem J 305 1995 479 484
29. A.A. Gorman M.A.J. Rodgers Current perspectives of singlet oxygen detection in biological environments J Photochem Photobiol B 14 1992 159 176
30. P.E. Goss K.M.E.H. Gwyn Current perspectives on aromatase inhibitors in breast cancer J Clin Oncol 12 1994 2460 2470
31. P.M. Gullino H.M. Pettigrew F.H. Grantham N-nitrosomethylurea as mammary gland carcinogen in rats J Natl Cancer Inst 54 1975 401 414
32. W.N. Hait W.T. De Rosa Calmodulin as a target for new chemotherapeutic strategies Cancer Invest 6 1988 499 511
33. P.E. Hartman D.M. Shankel Antimutagens and anticarcinogens: A survey of putative interceptor molecules Environ Mol Mutagen 15 1990 145 182
34. P. Hochstein A.S. Atallah The nature of oxidants and antioxidant systems in the inhibition of mutation and cancer Mutat Res 202 1988 363 375
35. G. Hocman Chemoprevention of cancer: Protease inhibitors Int J Biochem 24 1992 1365 1375
36. C. Ip G. White Mammary cancer chemoprevention by inorganic and organic selenium: Single agent treatment or in combination with vitamin E and their effects on in vitro immune functions Carcinogenesis 8 1987 1763 1766
37. C. Ip K. El-Bayoumy P. Upadhyaya Comparative effect of inorganic and organic selenocyanate derivatives in mammary cancer chemoprevention Carcinogenesis 15 1994 187 192
38. H. Kawano H. Murata S. Iriguchi Studies on ergothioneine. XI. Inhibitory effect on lipid peroxide formation in mouse liver Chem Pharm Bull 31 1983 1682 1687
39. G.J. Kelloff C.W. Boone J.A. Crowell Surrogate endpoint biomarkers for phase II cancer chemoprevention trials J Cell Biochem 19 1994 1 9
40. G.J. Kelloff C.W. Boone V.E. Steele Inhibition of chemical carcinogenesis J.C. Arcos M.F. Argus Y. Woo Chemical Induction of Cancer. Modulation and Combination Effects 10th ed 1995 Birkhauser Boston 73 122
41. G.J. Kelloff C.W. Boone V.E. Steele Mechanistic considerations in chemopreventive drug development J Cell Biochem 20 1994 1 24
42. G.J. Kelloff J.R. Fay V.E. Steele Epidermal growth factor receptor tyrosine kinase inhibitors as potential cancer chemopreventives Cancer Epidemiol Biomarkers Prev 5 1996 657 666
43. G.J. Kelloff E.T. Hawk J.E. Karp Progress in clinical chemoprevention Semin Oncol 24 1997 241 252
44. G.J. Kelloff R.A. Lubet J.R. Fay Farnesyl protein transferase inhibitors as potential cancer chemoprevention Cancer Epidemiol Biomarkers Prev 6 1997 267 282
45. G.J. Kelloff W.F. Malone C.W. Boone Progress in applied chemoprevention research Semin Oncol 17 1990 438 455
46. T.W. Kensler M.A. Trush K.Z. Guyton Free radicals as targets for cancer chemoprevention: Prospects and Problems V.E. Steele G.D. Stoner C.W. Boone Cellular and Molecular Targets for Chemoprevention 1992 CRC Press Boca Raton, FL 173 191
47. A. Keshavarzian S. Sedghi J. Kanofsky Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe Gastroenterology 103 1992 177 185
48. R. Khosravi-Far A.D. Cox K. Kato C.J. Der Protein prenylation: Key to ras function and cancer intervention? Cell Growth Differ 3 1992 461 469
49. E.A. Korytynski G.J. Kelloff W.A. Suk The development of an anchorage-independence assay using human lung tumor cells to screen potential chemopreventive agents Anticancer Res 16 1996 1091 1094
50. A.B. Kundu N.T. Telang M.R. Banerjee Binding of 7,12-dimethylbenz[a]anthracene to BALB/c mouse mammary gland DNA in organ culture J Natl Cancer Inst 61 1978 465 469
51. M.A. Levy M. Brandt K.M. Sheedy Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2 J Steroid Biochem Mol Biol 48 1994 197 206
52. U. Lichti E. Patterson H. Hennings S.H. Yuspa Differential retinoic acid inhibition of ornithine decarboxylase induction by 12-O-tetradecanoylphorbol-13-acetate and by germicidal ultraviolet light Cancer Res 41 1981 49 54
53. D.L. McCormick C.B. Adamowski A. Fiks R.C. Moon Lifetime dose-response relationships for mammary tumor induction by a single administration of N-methyl-N-nitrosourea Cancer Res 41 1981 1690 1694
54. D.L. McCormick R.C. Moon Antipromotional activity of dietary N-(4-hydroxyphenyl)retinamide in two-stage skin tumorigenesis in CD-1 and SENCAR mice Cancer Lett 31 1986 133 138
55. D.L. McCormick S.S. Ronan P.J. Becci Influence of total dose and dose schedule on induction of urinary bladder cancer in the mouse by N-butyl-N-(4-hydroxybutyl)nitrosamine Carcinogenesis 2 1981 251 254
56. R.G. Mehta V. Steele G.J. Kelloff Influence of thiols and inhibitors of prostaglandin biosynthesis on the carcinogen-induced development of mammary lesions in vitro Anticancer Res 11 1991 587 592
57. R.C. Moon R.G. Mehta Chemoprevention of experimental carcinogenesis in animals Prev Med 18 1989 576 591
58. R.C. Moon G.J. Kelloff C.J. Detrisac Chemoprevention of MNU-induced mammary tumors in the mature rat by 4-HPR and tamoxifen Anticancer Res 12 1992 1147 1154
59. R.C. Moon D.L. McCormick P.J. Becci Influence of 15 retinoic acid amides on urinary bladder carcinogenesis in the mouse Carcinogenesis 3 1982 1469 1472
60. R.C. Moon K.V.N. Rao C.J. Detrisac Hamster lung cancer model of carcinogenesis and chemoprevention Adv Exp Med Biol 320 1992 55 61
61. R.C. Moon K.V.N. Rao C.J. Detrisac Retinoid chemoprevention of lung cancer L. Wattenberg M. Lipkin C.W. Boone Cancer Chemoprevention 1992 CRC Press Boca Raton, FL 83 93
62. R.C. Moon K.V.N. Rao C.J. Detrisac Chemoprevention of respiratory tract neoplasia in the hamster by oltipraz, alone and in combination Int J Oncol 4 1994 661 667
63. C.M.H. Newman A.I. Magee Posttranslation processing of the ras superfamily of small GTP-binding proteins Biochim Biophys Acta 1155 1993 79 96
64. T.C. Normann Neurosecretion by exocytosis Int Rev Cytol 46 1976 1 77
65. M.S. O'Reilly The preclinical evaluation of angiogenesis inhibitors Invest New Drugs 15 1997 5 13
66. R.A. Parker S.J. Miller D.M. Gibson Phosphorylation of native 97-kDa 3-hydroxy-3-methylglutaryl-coenzyme A reductase from rat liver J Biol Chem 264 1984 4877 4885
67. A.E. Pegg L.M. Shantz C.S. Coleman Ornithine decarboxylase as a target for chemoprevention J Cell Biochem 22 1995 132 138
68. J.-P. Perchellet M.D. Owen T.D. Posey Inhibitory effects of glutathione level-raising agents and D-α-tocopherol on ornithine decarboxylase induction and mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate Carcinogenesis 6 1985 567 573
69. M.A. Pereira L.H. Barnes V.L. Rassman Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents Carcinogenesis 15 1994 1049 1054
70. G. Powis Signaling pathways as targets for anticancer drug development Pharmacol Ther 62 1994 57 95
71. H.J. Prochaska A.B. Santamaria Direct measurement of NAD(P)H: Quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers Ana Biochem 169 1998 328 336
72. C.V. Rao K. Tokumo J. Rigotty Chemoprevention of colon carcinogenesis by dietary administration of piroxicam, a-difluoromethylornithine, 16a-fluoro-5-androsten-17-one, and ellagic acid individually and in combination Cancer Res 51 1991 4528 4534
73. T.A. Ratko C.J. Detrisac N.M. Dinger Chemopreventive efficacy of combined retinoid and taxoxifen treatment following surgical excision of a primary mammary cancer in female rats Cancer Res 49 1989 4472 4476
74. B.S. Reddy Y. Maeura Tumor promotion by dietry fat in azoxymethane-induced colon carcinogenesis in female F344 rats: Influence of amount and source of dietary fat J Natl Cancer Inst 72 1984 745 750
75. B.S. Reddy J. Nayini K. Tokuma Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-α-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet Cancer Res 50 1990 2562 2568
76. R.J. Ruch R. Fransson S. Flodstrom Inhibition of hepatocyte gap junctional intercellular communication by endosulfan, chordane and heptachlor Carcinogenesis 11 1990 1097 1101
77. C.J. Rudd J.N. Mansbridge K.D. Suing Correlation of the ability of retinoids to inhibit promoter-induced anchorage-independent growth of JB6 mouse epidermal cells with their activation of retinoic acid receptor γ Cancer Lett 73 1993 41 49
78. I. Schmid C.H. Uittenbogaart B. Keld A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry J Immunol Methods 170 1994 145 157
79. S. Sharma J.D. Stutzman G.J. Kelloff Screnning of potential chemopreventive agents using biochemical markers of carcinogenesis Cancer Res 54 1994 5848 5855
80. T. Shiraishi M.K. Owada M. Tatsuka Specific inhibitors of tyrosine-specific protein kinases: Properties of 4-hydroxycinnamamide derivatives in vitro Cancer Res 49 1989 2374 2378
81. M.G. Simic Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis Mutat Res 202 1988 377 386
82. S.Y. Sit R.A. Parker I. Motoc Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors J Med Chem 33 1990 2982 2999
83. T.J. Slaga G.T. Bowden R.K. Boutwell Acetic acid, a potent stimulator of mouse epidermal macromolecular synthesis and hyperplasia but with weak tumor-promoting ability J Natl Cancer Inst 55 1975 983 987
84. V.L. Sparnins P.L. Venegas L.W. Wattenberg Glutathione S-transferase activity. Enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents J Natl Cancer Inst 68 1982 493 496
85. M.B. Sporn Approaches to prevention of epithelial cancer during the preneoplastic period Cancer Res 36 1976 2699 2702
86. V.E. Steele J.T. Arnold J. Van Arnold Evaluation of a rat tracheal epithelial cell culture assay system to identify respiratory carcinogens Environ Mol Mutagen 14 1989 48 54
87. V.E. Steele G.J. Kelloff B.P. Wilkinson Inhibition of transformation in cultured rat tracheal epithelial cells by potential chemopreventive agents Cancer Res 50 1990 2068 2074
88. V.E. Steele R.C. Moon R.A. Lubet Preclinical efficacy evaluation of potential chemopreventive agents in animal carcinogenesis models: Methods and results from the NCI Chemoprevention Drug Development Program J Cell Biochem 20 1994 32 54
89. V.E. Steele S. Sharma R. Mehta Use of in vitro assays to predict the efficacy of chemopreventive agents in whole animals J Cell Biochem 26 1996 29 53
90. G.D. Stoner Lung tumors in strain A mice as a bioassay for carcinogenicity of environmental chemicals Exp Lung Res 17 1991 405 423
91. G.D. Stoner M.A. Moore G.J. Kelloff Perspectives in cancer chemoprevention Environ Health Perspect 105 1997 945 954
92. D.M. Stresser G.S. Bailey D.E. Williams Indole-3-carbinol and β-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat Drug Metab Dispos 22 1994 383 391
93. S. Strickland T.R. Breitman F. Frickel Structure-activity relationships of a new series of retinoidal benzoic acid derivatives as measured by induction of differentiation of murine F9 teratocarcinoma cells and human HL-60 promyelocytic leukemia cells Cancer Res 43 1983 5268 5272
94. H.J. Thompson J.N. McGinley K. Rothhammer M. Singh Rapid induction of mammary intraductal proliferations, ductal carcinoma in situ and carcinomas by the injection of sexually immature female rats with 1-methy-1-nitrosourea Carcinogenesis 16 1955 2407 2411
95. W. Troll A.R. Kennedy Workshop report from the Division of Cancer Etiology, National Cancer Institute, National Institutes of Health: Protease inhibitors as cancer chemopreventive agents Cancer Res 49 1989 499 502
96. A.K. Verma G.G. Shapas H.M. Rice Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion Cancer Res 39 1979 419 425
97. N.J. Wald S.G. Thompson J.W. Densem Serum vitamin E and subsequent risk of cancer Br J Cancer 56 1987 69 72
98. B.S. Warren T.J. Slaga Mechanisms of inhibition of tumor progression Basic Life Sci 61 1993 279 289
99. L.W. Wattenberg Inhibitiors of chemical carcinogenesis Adv Cancer Res 26 1978 197 226
100. L.W. Wattenberg Chemoprevention of cancer Cancer Res 45 1985 1 8
101. L.W. Wattenberg Inhibition of carcinogenesis by minor dietary constituents Cancer Res 52 1992 2085S 2091S
102. L.W. Wattenberg An overview of chemoprevention: Current status and future prospects Proc Soc Exp Biol Med 216 1997 133 141
103. J.M. Whitfield R.P. Bird B.R. Chakravarthy Calcium: Cell cycle regulator, differentiator, killer, chemopreventor, and maybe, tumor promoter J Cell Biochem 22 1995 74 91
104. K.M. Wilbur F. Berhneim O.W. Shapiro The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents Arch Biochem Biophys 24 1949 305 313
105. B.G. Wood L.L. Washburn A.S. Mukherjee Hormonal regulation of lobulo-alveolar growth, functional differentiation and regression of whole mouse mammary gland in organ culture J Endocrinol 65 1975 1 6
106. H.M. Wortelboer E.C.M. van der Linden C.A. Kruif Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures Food Chem Toxicol 30 1992 589 599
107. H.-Q. Wu J. Masset-Brown D.J. Tweedie Induction of microsomal NADPH-cytochrome P-450 reductase and cytochrome P-450IVA1 (P-450LAω) by dehydroepiandrosterone in rats: A possible peroxisomal proliferator Cancer Res 49 1989 2337 2343