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Volumn 49, Issue 6, 1999, Pages 716-720

Exploring nonnatural evolutionary pathways by saturation mutagenesis: Rapid improvement of protein function

Author keywords

Directed evolution; Fitness; Random mutagenesis; Saturation mutagenesis; Subtilisin; Thermostability

Indexed keywords

SUBTILISIN;

EID: 0033280672     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00006593     Document Type: Article
Times cited : (184)

References (23)
  • 2
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    • (1991) J Mol Biol , vol.217 , pp. 721-729
    • Bordo, D.1    Argos, P.2
  • 3
    • 0027205210 scopus 로고
    • Tuning the activity of an enzyme for unusual environments: Sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5618-5622
    • Chen, K.1    Arnold, F.H.2
  • 19
    • 0023037143 scopus 로고
    • Advantages to mutagenesis techniques generating populations containing the complete spectrum of single codon changes
    • (1986) J Theor Biol , vol.123 , pp. 261-279
    • Sirotkin, K.1
  • 20
    • 0028050350 scopus 로고
    • Rapid evolution of a protein in vitro by DNA shuffling
    • (1994) Nature , vol.370 , pp. 389-391
    • Stemmer, W.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.