Effects of cobalt hexammine on folding and self-cleavage of the Neurospora VS ribozyme

Journal of Molecular Biology

Volumn 309, Issue 1, 2001, Pages 45-56

  Maguire, Jonathon L ^a   Collins, Richard A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Catalytic RNA; Cation; Kissing loop; Pseudoknot; RNA folding

Indexed keywords

COBALT DERIVATIVE; MAGNESIUM ION; RIBOZYME; RIBOZYME VS; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CATALYSIS; CATALYST; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; NEUROSPORA; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

NEUROSPORA;

EID: 0035946946     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4625     Document Type: Article

References (36)

1. The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone
2. Strategies for RNA folding
3. Thermodynamics of stabilization of RNA pseudoknots by cobalt(III) hexaammine
4. 2+(aq) binding sites
5. Solution structure and thermodynamics of a divalent metal ion binding site in an RNA pseudoknot
6. Determination of metal ion binding sites within the hairpin ribozyme domains by NMR
7. Metal-binding sites in the major groove of a large ribozyme domain
8. Structure and thermodynamics of metal binding in the P5 helix of a group I intron ribozyme
9. Iron regulatory element and internal loop/bulge structure for ferritin mRNA studied by cobalt(III) hexammine binding, molecular modeling, and NMR spectroscopy
10. Solution structure of a metal-binding site in the major groove of RNA complexed with cobalt (III) hexammine
11. Metal interactions with a GAAA RNA tetraloop characterized by (31)P NMR and phosphorothioate substitutions
12. Solution structure of Cobalt(III)hexammine complexed to the GAAA tetraloop, and metal-ion binding to G. A mismatches
13. A unique mechanism for RNA catalysis: The role of metal cofactors in hairpin ribozyme cleavage
14. An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis
15. Unusual metal ion catalysis in an acyl-transferase ribozyme
16. Metal ions play a passive role in the hairpin ribozyme catalysed reaction
17. The solvent-protected core of the hairpin ribozyme-substrate complex
18. Structure and activity of the hairpin ribozyme in its natural junction conformation: Effect of metal ions
19. Tertiary structure formation in the hairpin ribozyme monitored by fluorescence resonance energy transfer
20. Ionic interactions and the global conformations of the hammerhead ribozyme
21. Impact of phosphorothioate substitutions on the thermodynamic stability of an RNA GAAA tetraloop: An unexpected stabilization
22. A secondary-structure model for the self-cleaving region of Neurospora VS RNA
23. General acid-base catalysis in the mechanism of a hepatitis delta virus ribozyme
24. Spermine switches a Neurospora VS ribozyme from slow cis cleavage to fast trans cleavage
25. Enhancement of Neurospora VS ribozyme cleavage by tuberactinomycin antibiotics
26. Effects of polyvalent cations on the folding of an rRNA three-way junction and binding of ribosomal protein S15
27. Identification of phosphates involved in metal binding and tertiary interactions in the core of the Neurospora VS ribozyme
28. Rearrangement of a stable secondary structure during VS ribozyme catalysis
29. A long-range pseudoknot is required for activity of the Neurospora VS ribozyme
30. Smaller, faster ribozymes reveal the catalytic core of Neurospora VS RNA
31. Nucleotide sequence requirements for self-cleavage of Neurospora VS RNA
32. A guide for probing native small nuclear RNA and ribonucleoprotein structures
33. A secondary structure model for the self-cleaving region of Neurospora VS RNA
34. Chemical probes for higher order structure in RNA
35. Reaction conditions and kinetics of self-cleavage of a ribozyme derived from Neurospora VS RNA