The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation

British Journal of Haematology

Volumn 105, Issue 1, 1999, Pages 225-240

  Gattei, Valter ^a   Degan, Massimo ^a   Rossi, Francesca Maria ^a   Iuliis, Angela D E ^a   Mazzocco, Francesca Tassan ^a   Cesa, Emiliana ^a   Aldfnucci, Donatella ^a   Zagonel, Vittorina ^a   Pinto, Antonio ^a  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Acute myeloid leukaemia; Bone marrow microenvironment; GDNF; RET; Tyrosine kinase

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; TYROSINE KINASE RECEPTOR;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BONE MARROW CELLS; CELL TRANSFORMATION, NEOPLASTIC; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; LEUKEMIA, MONOCYTIC, ACUTE; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; PHENOTYPE; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0032940386     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.1999.01285.x     Document Type: Article

References (59)

1. Arland, M., Fielder, W.. Samalecos, A. & Hossfeld, D.K. (1994) Absence of point mutations in a functionally important part of the extracellular domain of the c-kit proto-oncogene in a series of patients with acute myeloid leukemia (AML). Leukemia, 8, 498-501.
2. Armitage, P. & Berry, G. (1987) Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford.
3. Avantaggiato, V., Dathan. N., Grieco, M., Fabien, N., Lazzaro, D., Fusco, A., Simeone, A. & Santoro, M. (1994) Developmental expression of the RET proto-oncogene. Cell Growth and Differentiation, 5, 305-311.
4. Baloh/R.H., Tansey, M.G., Golden, J.P., Creedon, D.J., Heuckeroth, R.O., Keck, C.L., Zimonjic, D.B., Popescu, N.C., Johnson, E.M., Jr & Milbrandt, J. (1997) TrnR2, a novel receptor that mediates Neurturin and GDNF signalling through Ret. Neuron, 18, 793802.
5. Bene, M.C., Barnier, M., Casasnovas, R.O., Castoldi, G., Knapp, W., Lanza, F., Ludwig, W.D., Matutes, E., Orfao, A., Sperling, C. & van't Veer, M.B. (1998) The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias. Blood, 92, 596-599.
6. Bennett, J.M.. Catovsky, D., Daniel, M.-T., Flandrin, G., Gallon, D.A.G., Gralnick. H.R. & Sultan, C. French-American-British (FAB) Cooperative Group (1985) Proposed revised criteria for the classification of acute myeloid leukaemia. Annals of Internal Medicine, 103, 626-629.
7. Bennett, J.M., Catovsky, D., Daniel, M.-T., Flandrin, G., Gallon, D.A.G.. Gralnick, H.R. & Sultan, C. (1991) Proposal for the recognition of minimally differentiated acute myeloid leukaemia (AML-MO). British Journal of llaematology. 78, 325-329.
8. Bernasconi, S., Matteucci, C., Sironi, M., Conni, M., Colotta. F., Mosca, M., Colombo, N., Bonazzi, C., Landoni. F.. Corbetta, G., Mantovani, A. & Allavena. P. (1995) FJfect of granulocytemonocyte colony-stimulating factor (GM-CSF) on expression of adhesion molecules and production of cytokines in blood monocyte and ovarian cancer-associated macrophages. International Journal of Cancer, 60, 300-307.
9. Bradstock, K.F. & Gottlieb, D.J. (1995) Interaction of acute leukemia cells with bone marrow microenvironment: implications for control of minimal residual disease. Leukemia and Lymphoma, 18, 1-16.
10. Buj-Bello, A., Adu, J., Pinôn, L.G.P., Horton, A., Thompson, J., Rosenthal, A.. Chinchetru, M., Buchman V.L. & Davies, A. (1997) Neurturin resposivcness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature, 387, 721-725.
11. Chomczynsky, P. & Sacchi, N. (1987) Single step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
12. Cross, N.C.P. (1995) Quantitative PCR techniques and applications. British Journal of llaematology. 89, 693-697.
13. Dubreuil, P., Torres, H., Courcoul, M.-A.. Birg, F. & Mannoni, P. (1988) c-fms expression is a molecular marker of human acute myeloid leukemias. Blood, 72, 1081-1085.
14. Eng, C. (1996) The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschprung's disease. New England Journal of Medicine. 335, 943-951.
15. Fantl, W.J., Johnson, D.E. & Williams. T.W. (1993) Signalling by receptor tyrosine kinases. Annual Review of Biochemistry, 62,453481.
16. Gattei, V, Aldinucci, D., Quinn, M.W.J., Degan, M., Cozzi, M., Perin, V, De Iuliis, A., Juzbasic, S., Improta, S., Athanasou, N.A., Ashman, L.K. & Pinton, A. (1996) Human osteoclasts and preosteoclasts cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membranebound stem cell factor. Cell Growth and Differentiation. 7, 753-763.
17. Gattei, V., Cerrato, A.. Celetti, A., Dcgan. M.. De Iuliis. A.. Rossi, F.M., Chiappetta, G., Consales, C., Improta, S., Zagonel, V., Aldinucci, D., Agosti. V, Santoro. M.. Vecchio, G., Pinto, A. & Grieco, M. (1997a) Expression of the RET receptor tyrosine kinase in normal and leukemic human hematopoietic cells. Blood, 89, 2925-2937.
18. Gattei. V., Degan. M., De Iuliis, A., Rossi, M.F., Aldinucci, D. & Pinto, A. (1997b) Competitive reverse transcriptase PCR: a useful alternative to Northern blotting for quantitative estimation of relative abundances of specific mRNAs in precious samples. Biochemical Journal. 325, 565-567.
19. Gattei, V, Degan, M., Gloghini, A., De Iuliis, A., Improta, S., Rossi, P.M., Aldinucci. D., Perin. V, Serraino, D., Babare, R.. Zagonel, V, Gruss, H.-J., Carbone, A. & Pinto, A. (1997c) CD30 ligand is frequently expressed in human hematopoietic malignancies of myeloid and lymphoid origin. Blood. 89, 2048-2059.
20. Hickstcin, D.D., Hickey, M.J. & Collins, S.T. (1988) Transcriptional regulation of the leukocyte adherence protein b subunit during human myeloid differentiation. Journal of Biological Cliemistry, 263, 13863-13867.
21. Jing, S., Wen. D.. Yu, Y., Holst, P.L., Luo, Y, Fang. M., Tamir, R., Antonio, L, Hu, Z., Cupples, R., Louis, J.C., Hu, S., Altrock, B.W. & Fox, G.M. (1996) GDNF-induced activation of the RET protein tyrosine kinase is mediated by GDNFR-a, a novel receptor for GDNF. Cell, 85, 1113-1124.
22. Khalidi, U.S.. Medeiros, L.J., Chang, K.L., Brynes, R.K., Slovak, M.L. & Arber, D.A. (1998) The immunophenotype of adult acute myeloid leukemia: high frequency of lymphoid antigen expression and comparison of immunophenotype, French-American-British classification, and karyotypic abnormalities. American Journal of Clinical Pathology. 109, 211-220.
23. Klein. R.D., Sherman, D., Ho, W.-H., Stone, D., Benne, G.L., Moffat, B., Vandlen, R.. Simmons, L., Gu, Q., Hongo, J.-A., Devaux, B., Poulsen, K.. Armanini, M., Nozaki, I., Asai, N., Goddard, A., Phillips, H., Henderson, C.E., Takahashi. M. & Rosenthal. A. (1997) A GPI-Iinked protein that interacts with Ret to form a candidate neurturin receptor. Nature, 387, 717-721.
24. Kotzbauer, P.T., Lampe, P.A., Heuckeroth, R.O., Golden, J.P., Creedon, D.J., Johnson, E.M., Jr & Milbrandt, J. (1997) Neurturin, a relative of glial cell line-derived neurotrophic factor. Nature, 384, 467470.
25. Lin, L.F., Doherty. D.H., Lile, J.D., Bektesh, S. & Collins. S. (1993) GDNF: a glial cell line-derived neurothropic factor for midbrain dopaminergic neurons. Science, 260, 1130-1132.
26. Manfioletti, G., Gattei, V. Buratti, E., Rustighi, A., De Iuliis, A., Aldinucci, D., Goodwin, G.H. & Pinto, A. (1995) Differential expression of a novel proline-rich homeobox gene (Prh) in human hematolymphopoietic cells. Blood, 85, 1237-1245.
27. Marshall, G.M., Peaston, A.E., Hocker, J.E., Smith. S.A., Hansford, L.M., Tobias, V, Norris, M.D., Haber, M.. Smith, O.P., Lorenzo, M.J., Ponder, B.A. & Hancock, J.F. (1997) Expression of multiple endocrine neoplasia 2B RET in neuroblastoma cells alters cell adhesion in vitro, enhances metastatic behavior in vivo, and activates Jun kinase. Cancer Research, 57, 5399-5405.
28. Mayani, H. (1996) Composition and function of the hemopoietic microenvironment in human myeloid leukemia. Leukemia, 10, 1041-1047.
29. Miyamoto, S.. Teramoto. H.. Gutkin. J.S. & Yamada, K.M. (1996) Intcgrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptor. Journal of Cell Biology. 135, 1633-1642.
30. Moore, M.W., Klein, R.D., Farinas, L, Sauer, H., Armanini, M., Phillips. H.. Reichardt. L.F.. Ryan. A.M.. Carver-Moore, K. & Rosenthal, A. (1996) Renal and neural abnormalities in mice lacking GDNF. Nature, 382, 76-79.
31. Oberg. F., Anton, R., Stockbauer, P., Larsson, L.-G. & Nilsson, K. (1989) Surface antigen expression in human monoblastic U937 cells induced to differentiate and in clones infected with v-myc. Leukocyte Typing IV (ed. by Knapp et al), p. 926. Oxford University Press.
32. Odom. LE, Lampkin, B.C., Tannous, R., Buckley, J.D. & Hammond, G.D. (1990) Acute myeloblastic leukemia: a unique subtype. A review from the Childrens Cancer Study Group. Leukemia Research, 14, 1-10.
33. Piacibello. W., Fubini, L., Sanavio, F., Brizzi. M.F., Severino, A., Garetto. L, Stacchini. A., Pcgoraro, L. & Aglietta. M. (1995) Effect of human FLT3 ligand on myeloid leukemia cell growth: heterogeneity in response and synergy with other hematopoietic factors. Blood. 86, 4105-4114.
34. Pichel. J.G., Shen, L., Shen, H.Z., Granholm, A.C., Drago, ]., Grinberg, A., Lee, E.J., Huang, S.P., Saarma, M., Hoffer, B.J., Sariola, H. & Westphal, II. (1996) Defects in enteric innervation and kidney development in mice lacking GDNF. Nature, 382, 7376.
35. Rosmarin, A.G., Weil, S.C., Rosner, G.L., Griffin, J.D., Arnaout, M.A. & Tenen, D.G. (1989) Differential expression of CDllb/CD18 (Mol) and myeloperoxidase genes during myeloid differentiation. Blood. 73, 131-136.
36. Rosnet. O., Buhring. HJ., Marchetto, S., Rappold, I., Lavagna, C., Sainty, D., Arnoulet, C., Chabannon, C., Kanz, L., Hannum, C. & Birnbaum, D. (1996) Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia. 10, 238-248.
37. Rothe, G. & Schmilz, G., for the Working Group on Flow Cytometry and Image Analysis (1996) Consensus protocol for the flow cytometry immunophenotyping of hematopoietic malignancies. Leukemia, 10, 877-895.
38. Sanchez, M.P., Silos-Santiago, I., Frisen, ]., He, B., Lira, S.A. & Barbacid, M. (1996) Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature, 382, 70-73.
39. Sanicola, M., Hession, C., Worley, D.. Carmillo, P., Ehrenfels, C., \Valus, L. Robinson, S., Jaworski, G., Wei, H., Tizard, R., Whitty, A., Pepinsky, R.B. & Cate, R.L. (1997) Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proceedings of the National Academy of Sciences of the United States of America, 94, 6238-6243.
40. Santoro, M.. Wong, W.T., Aroca, P., Santos, E.. Matoskova, B.. Grieco, M., Fusco, A. & Di Fiore, P.P. (1994) An epidermal growth factor receptor/RET chimera generates mitogenic and transforming signals: evidence for a RET-specific signaling pathway. Molecular and Cellular Biology, 14, 663-675.
41. Seymour, J.F., Pierce, S.A., Kantarjian, U.M.. Keating. M.J. & Estey, E.H. (1994) Investigation of karyotypic, morphologic and clinical features in patients with acute myeloid leukemia blast cells expressing the neural cell adhesion molecule (CD56). Leukemia, 8, 823-826.
42. Siebert, P.D. & Larrick, J.W. (1993) PCR MIMICs. competitive DNA fragments for use as internal standards in quantitative PCR. BioTechniques, 14, 244-249.
43. Simmons, D., Tan, S., Tenen. D., Nicholson-U'eller, A. & Seed, B. (1989) Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood, 73, 284-289.
44. Slavin, J. (1996) The role of cytokines in wound healing. Journal of Pathology. 178, 5-10.
45. Springall, F., O'Mara, S., ShounanY., Todd, A., Ford, D. & Hand, H. (1993) c-fms point mutations in acute myeloid leukemia: fact of fiction? Leukemia. 7, 978-985.
46. Taichman, R.S. & Emerson, S.G. (1996) Human osteosarcoma cell lines MG-63 and Saos-2 produce G-CSF and GM-CSF: identification and partial characterization of cell-associated isoforms. Experimental Heinatology, 24, 509-513.
47. Takahashi, M., Buma, Y., Iwamoto, T., Inaguma, Y., Ikeda, H. & Hiai, H. (1988) Cloning and expression of the RET proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains. Oncogene, 3, 571-575.
48. Takahashi. M., Buma, Y. & Taniguchi. M. (1991) Identification of the RET proto-oncogene products in neuroblastoma and leukemia cells. Oncogene, 6, 297-301.
49. Testa, U, Masciulli, R.. Tritarelli, E., Pastorino, R., Mariani. G., Martucci, R., Barberi, T, Camagna, A., Valtieri, M. & Peschle, C. (1993) Transforming growth factor-|3 potentiates vitamin D3-induced terminal monocytic differentiation of human leukemic cell lines. Journal of Immunology, 150, 2418-2430.
50. Tobelem, G., Jacquillat, C., Chastang, C., Auclerc, M.F., Lechevallier, T., Weil, M., Daniel, M.T., Flandrin, G., Harrousseau, J.L., Schaison, G., Boiron, M. & Bernard, ]. (1980) Acute monoblastic leukemia: a clinical and biologic study of 74 cases. Blood, 55, 7176.
51. Treanor, J.J.S., Goodman, L., de Sauvage, F., Stone, D.M., Poulsen, K.T., Beck, C.D., Gray, C., Armanini. M.P., Pollock, R.A., Hefti, F., Phillips, U.S., Goddard, A., Moore, M.W., Buj-Bello, A., Davies, A.M., Asai, N., Takahashi, M., Vendlen. R., Henderson, C.E. & Rosenthal, A. (1996) Characterization of a multicomponent receptor for GDNF. Nature, 382, 80-83.
52. Trupp, M., Ryden, M., Jornvall. H., Funakoshi, H., Timmusk, T., Arenas. E. & Ibanez. C.F. (1995) Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons. Journal of Cell Biology. 130, 137-148.
53. Tsuzuki, T., Takahashi, M., Asai, N., Iwashita. T.. Matsuyama. M. & Asai. J. (1995) Spatial and temporal expression of the RETprotooncogene in embryonic, infant and adult rat tissues. Oncogene. 10, 191-198.
54. van der Geer, P.. Hunter, T. & Lindberg, R.A. (1994) Receptor protein-tyrosine kinases and their signal transduction pathways. Annual Reviews of Cellular Biology. 10, 251-337.
55. van Puijenbroek, A.A., van \Veering, D.H., van den Brink, C.E., Bos, J.L., van der Saag. P.T., de Laat, S.W. & den Hertog. J. (1997) Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with 'sustained ERK2 activation. Oncogene. 14, 1147-1157.
56. Visser. M.. Hofstra, R.M.W., Stülp. R.P., Wu. Y.. Buys, C.H.C.M., Willemze, R. & Landegent, J.E. (1997) Absence of mutations in the RET gene in acute myeloid leukemia. Annals of lleinatology. 75, 87-90.
57. Visser. M., Sonneveld, R.D., Willemze, R. & Landegent, J.E. (1996) Haemopoietic growth factor tyrosine kinase receptor expression profiles in normal haemopoiesis. British Journal ofllaematology. 94, 236-241.
58. Wang. A.M., Doyle, M.V. & Mark, D.E (1989) Quantitation of mRNA by polymerase chain reaction. Proceedings of the National Academy of Sciences of the United States of America. 86, 9717-9721.
59. Williams, M.A., Kelsey. S.M.. Collins. P.W., Gutteridge, C.N. & Newland. A.C. (1995) Administration of rHuGM-CSF activates monocyte reactive oxygen species secretion and adhesion molecule expression i;i vivo in patients following high-dose chemotherapy. British Journal of Haematology. 90, 31-40.