Robust prostate-specific expression for targeted gene therapy based on the human kallikrein 2 promoter

Human Gene Therapy

Volumn 12, Issue 5, 2001, Pages 549-561

  Xie, X ^a   Zhao, X ^a   Liu, Y ^a   Young, C Y F ^b   Tindall, D J ^b   Slawin, K M ^a   Spencer, D M ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; GREEN FLUORESCENT PROTEIN; HUMAN KALLIKREIN 2; KALLIKREIN; METRIBOLONE; RNA; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE INDUCTION; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROSTATE CANCER; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; BINDING SITES; BRAIN; CYTOMEGALOVIRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENHANCER ELEMENTS (GENETICS); FLOW CYTOMETRY; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LIVER; LUMINESCENT PROTEINS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; NEOPLASM TRANSPLANTATION; PLASMIDS; PROMOTER REGIONS (GENETICS); PROSTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, FLUORESCENCE; TISSUE KALLIKREINS; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION;

ADENOVIRIDAE; ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; MINK CELL FOCUS-FORMING VIRUS;

EID: 0035937310     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303401300042483     Document Type: Article

References (39)

1. Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer
2. Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter
3. High level of expression in the prostate of a human glandular kallikrein mRNA related to prostate-specific antigen
4. Human glandular kallikrein 2 (hK2) expression in prostatic intraepithelial neoplasia and adenocarcinoma: A novel prostate cancer marker
5. Human glandular kallikrein 2 expression in prostate adenocarcinoma and lymph node metastases
6. Improved artificial death switches based on caspases and FADD
7. Stable in vivo gene transduction via a novel adenoviral/retroviral chimeric vector
8. Emergence of genetic instability in children treated for leukemia
9. More is better: Activators and repressors from the same gene
10. Development of prostate-specific antigen promoter-based gene therapy for androgen-independent human prostate cancer
11. Construction of adenovirus vectors through Cre-lox recombination
12. A simplified system for generating recombinant adenoviruses
13. In situ gene therapy for adenocarcinoma of the prostate: A phase I clinical trial
14. Autocrine regulation of prostate-specific antigen gene expression in a human prostatic cancer (LNCaP) subline
15. In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene
16. Prostate-specific antigen promoter/enhancer driven gene therapy for prostate cancer: Construction and testing of a tissue-specific adenovirus vector
17. An adenovirus vector for gene transfer into neurons and glia in the brain
18. Characterization of the gene for prostate-specific antigen, a human glandular kallikrein
19. Molecular biology of tissue kallikrein
20. In vivo gene therapy for prostate cancer: Pre-clinical evaluation of two different enzyme-directed prodrug therapy systems delivered by identical adenovirus vectors
21. Molecular forms of prostate-specific antigen and the human kallikrein gene family: A new era
22. Androgen induction of a human prostate-specific kallikrein, hKLK2: Characterization of an androgen response element in the 5′ promoter region of the gene
23. Identification of a positive regulatory element responsible for tissue-specific expression of prostate-specific antigen
24. Gene transfer and therapy with adenoviral vector in rats with diethylnitrosamine-induced hepatocellular carcinoma
25. Characterization of the human kallikrein locus
26. Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
27. Primary structure of a human glandular kallikrein gene
28. Prostate-specific antigen expression is regulated by an upstream enhancer
29. Suicide gene therapy toxicity after multiple and repeat injections in patients with localized prostate cancer
30. Detection of metastatic prostate cancer using a splice variant-specific RT-PCR assay for human glandular kallikrein
31. Controlling signal transduction with synthetic ligands
32. Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines
33. Immunohistochemical study suggesting a complementary role of kallikreins hK2 and hK3 (prostate-specific antigen) in the functional analysis of human prostate tumors
34. Systemic gene therapy of murine melanoma using tissue specific expression of the HSVtk gene involves an immune component
35. Targeting adenovirus
36. Effect of bile and pancreatic juice on adenoviral-mediated gene delivery: Implications on the feasibility of gene delivery through ERCP
37. Adenovirus-mediated gene transfer of herpes simplex virus thymidine kinase in an ascites model of human breast cancer
38. Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein
39. Identification of the transcriptional regulatory sequences of human kallikrein 2 and their use in the construction of calydon virus 764, an attenuated replication competent adenovirus for prostate cancer therapy