Are trigger sequences essential in the folding of two-stranded α-helical coiled-coils?

Journal of Molecular Biology

Volumn 306, Issue 3, 2001, Pages 539-553

  Lee, Darin L ^a   Lavigne, Pierre ^b   Hodges, Robert S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Coiled coil; Cortexillin; GCN4; Protein folding; Protein stability

Indexed keywords

ACTIN BINDING PROTEIN; CORTEXILLIN I; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CIRCULAR DICHROISM; ELECTRICITY; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; SPECTROSCOPY; ULTRACENTRIFUGATION; YEAST;

DICTYOSTELIUM DISCOIDEUM;

EID: 0035936694     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4351     Document Type: Article

References (57)

1. Amino-acid sequence of rabbit skeletal tropomyosin and its coiled-coil structure
2. The packing of α-helices: Simple coiled-coils
3. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil
4. Predicting oligomerization states of coiled coils
5. Boehringer Mannheim award lecture 1995. La conference Boehringer Mannheim 1995. De novo design of alpha-helical proteins: Basic research to medical applications
6. De novo design of α-helical coiled coils and bundles: Models for the development of protein-design principles
7. Helical peptide and protein design
8. Synthesis of a model protein of defined secondary and quaternary structure. Effect of chain length on the stabilization and formation of two-stranded alpha-helical coiled-coils
9. Subdomain folding of the coiled coil leucine zipper from the bZIP transcriptional activator GCN4
10. Effect of chain length on the formation and stability of synthetic alpha-helical coiled coils
11. Characterization of a new four-chain coiled-coil: Influence of chain length on stability
12. De novo design of a model peptide sequence to examine the effects of single amino acid substitutions in the hydrophobic core on both stability and oligomerization state of coiled-coils
13. The role of position a in determining the stability and oligomerization state of alpha-helical coiled coils: 20 Amino acid stability coefficients in the hydrophobic core of proteins
14. Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled coil: 20 Amino acid substitutions in position "d"
15. Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect
16. The measure of interior disorder in a folded protein and its contribution to stability
17. The net energetic contribution of interhelical electrostatic attractions to coiled-coil stability
18. Protein destabilization by electrostatic repulsions in the two-stranded alpha-helical coiled-coil/leucine zipper
19. Investigation of electrostatic interactions in two-stranded coiled-coils through residue shuffling
20. Orientation, positional, additivity, and oligomerization-state effects of interhelical ion pairs in alpha-helical coiled-coils
21. A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids
22. α-helical propensities of amino acids in the hydrophobic face of an amphipathic α-helix
23. Stabilization of protein structure by interaction of alpha-helix dipole with a charged side-chain
24. Helix capping
25. Helix capping in the GCN4 leucine zipper
26. Ion-pair and charged hydrogen-bond interactions between histidine and aspartate in a peptide helix
27. Energetics of polar side-chain interactions in helical peptides: Salt effects on ion pairs and hydrogen bonds
28. Is protein folding hierarchic? I. Local structure and peptide folding
29. Tropomyosin: A model protein for studying coiled-coil and α-helix stabilization
30. Unzipping the secrets of coiled-coils
31. An autonomous folding unit mediates the assembly of two-stranded coiled coils
32. A distinct 14 residue site triggers coiled-coil formation in cortexillin I
33. Spare the rod, spoil the regulation: Necessity for a myosin rod
34. The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges
35. A distinct seven-residue trigger sequence is indispensable for proper coiled-coil formation of the human macrophage scavenger receptor oligomerization domain
36. Leucine is the most stabilizing aliphatic amino acid in the d position of a dimeric leucine zipper coiled coil
37. A switch between two, three, and four-stranded coiled coils in GCN4 leucine zipper mutants
38. An engineered allosteric switch in leucine-zipper oligomerization
39. Crystal structures of a single coiled-coil peptide in two oligomeric states reveal the basis for structural polymorphism
40. Buried polar residues and structural specificity in the GCN4 leucine zipper
41. Peptide "Velcro*": Design of a heterodimeric coiled coil
42. Do salt bridges stabilize proteins? A continuum electrostatic analysis
43. Measurement of interhelical electrostatic interactions in the GCN4 leucine zipper
44. Interhelical salt bridges, coiled-coil stability, and specificity of dimerization
45. Electrostatic interactions in the GCN4 leucine zipper: Substantial contributions arise from intramolecular interactions enhanced on binding
46. The effects of interhelical electrostatic repulsions between glutamic acid residues in controlling the dimerization and stability of two-stranded alpha-helical coiled-coils
47. Effects of α-helical and β-sheet propensities of amino acids on protein stability
48. Are buried salt bridges important for protein stability and conformational specificity?
49. Construction, purification, and characterization of a hybrid protein comprising the DNA binding domain of the LexA repressor and the Jun leucine zipper: A circular dichroism and mutagenesis study
50. Periodicity of amide proton exchange rates in a coiled-coil leucine zipper peptide
51. 13C alpha NMR chemical shifts and local unfolding curves
52. Rapid in situ neutralization protocols for Boc and Fmoc solid-phase chemistries
53. Hydrophilic interaction/cation-exchange chromatography for the purification of synthetic peptides from closely related impurities: Serine side-chain acetylated peptides
54. Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper
55. Contribution of translational and rotational entropy to the unfolding of a dimeric coiled-coil
56. Circular dichroic analysis
57. Importance of intra-chain ionic interactions in stabilizing α-helices in proteins