Buried polar residues and structural specificity in the GCN4 leucine zipper

Nature Structural Biology

Volumn 3, Issue 12, 1996, Pages 1011-1018

  Gonzalez Jr , Lino ^a   Woolfson, Derek N ^a,b   Alber, Tom ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINE; DIMER; GLYCINE; LEUCINE ZIPPER PROTEIN; LYSINE; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; OLIGOMERIZATION; POLARIZATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; DIMERIZATION; DNA-BINDING PROTEINS; FUNGAL PROTEINS; LEUCINE ZIPPERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 16944366990     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb1296-1011     Document Type: Article

References (21)

1. West, M.W. & Hecht, M.H. Binary patterning of polar and nonpolar amino acids in the sequences and structures of native proteins. Protein Sci. 4, 2032-2039 (1995).
2. Bowie, J.U., Luthy, R. & Eisenberg, D. A method to identify protein sequences that fold into a known three-dimensional structure. Science 253, 164-170 (1991).
3. Dill, K.A. et al. Principles of protein folding - A perspective from simple exact models. Protein Sci. 4, 561-602 (1995).
4. Cordes, M.H.J, Davidson, A.R. & Sauer, R.T. Sequence space, folding and protein design. Curr. Opin. Struct. Biol. 6, 3-10 (1996).
5. Desjarlais, J.R. & Handel, T.M. New strategies in protein design. Curr. Opin. Biotechnol. 6, 460-466 (1995).
6. Kamtekar, S. & Hecht, M.H. The four-helix bundle: what determines a fold? FASEB J. 9, 1013-1022 (1995).
7. Betz, S.F., Bryson, J.W. & DeGrado, W.F. Native-like and structurally characterized designed α-helical bundles. Curr. Opin. Struct. Biol. 5, 457-463 (1995).
8. Harbury, P.E., Zhang, T., Kim, P.S., & Alber, T.A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine-zipper mutants. Science 262, 1401-1407 (1993).
9. Cohen, C. & Parry, A.D. α-helical coiled coils and bundles: how to design an α-helical protein. Proteins 7, 1-15 (1990).
10. Hodges, R.S., Sodek, J., Smillie, L.B. & Jurasek, L. Tropomyosin: amino acid sequence and coiled-coil structure. Cold Spring Harbor Symp. Quant Biol. 37, 299-310 (1972).
11. Conway, J.F. & Parry, D.A. Structural features in the heptad substructure and longer range repeats of two-stranded α-fibrous proteins. Int. J. Biol. Macromol. 12, 328-334 (1990).
12. Conway, J.F. & Parry, D.A. Three-stranded α-fibrous proteins: the heptad repeat and its implications for structure. Int. J. Biol. Macromol. 13, 14-16 (1991).
13. O'Shea, E.K., Klemm, J.D., Kim, P.S. & Alber, T. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil. Science 254, 539-544 (1991).
14. Gonzalez, Jr., L., Plecs, J.J. & Alber, T. An engineered allosteric switch in leucine-zipper oligomerization. Nature Struct. Biol. 3, 510-515 (1996).
15. Gonzalez, Jr., L., Brown, R. A., Richardson, D. & Alber, T. Crystal structures of a single coiled-coil peptide in two oligomeric states reveal the basis for structural polymorphism. Nature Struct. Biol. 3, 1002-1010 (1996).
16. Potekhin, S.A., Medvedkin, V.N., Kashparov, I.A. & Venyaminov, S.U. Synthesis and properties of the peptide corresponding to the mutant form of the leucine zipper of the transcriptional activator GCN4 from yeast. Protein Eng. 7, 1097-1101 (1994).
17. Glover, J.N.M. & Harrison, S.C. Crystal structure of the heterodimeric bZIP transcription factor c-Fos - c-Jun bound to DNA. Nature 373, 257-261 (1995).
18. Junius, F. K. et al. Nuclear magnetic resonance characterization of the Jun leucine zipper domain: unusual properties of coiled-coil interfacial polar residues. Biochemistry 34, 6164-6174 (1995).
19. Woolfson, D.N. & Alber, T. Predicting oligomerization states of coiled coils. Prot. Sci. 4, 1596-1607 (1995).
20. Lumb, K.J., & Kim, P.S. A buried polar interaction imparts structural uniqueness in a designed heterodimeric coiled coil. Biochemistry 34, 8642-8648 (1995).
21. Wendt, H., Berger, C., Baici, A., Thomas, R.M. & Bosshard, H.R. Kinetics of folding of leucine zipper domains. Biochemistry 34, 4097-4107 (1995).