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1
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0032508511
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Use of a heterodimeric coiled-coil system for biosensor application and affinity purification
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Chao H., Bautista D.L., Litowski J., Irvin R.T., Hodges R.S. Use of a heterodimeric coiled-coil system for biosensor application and affinity purification. J Chromatogr B Biomed Appl. 715:1998;307-329.
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J Chromatogr B Biomed Appl
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Chao, H.1
Bautista, D.L.2
Litowski, J.3
Irvin, R.T.4
Hodges, R.S.5
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2
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0032541038
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Reversible hydrogels from self-assembling artificial proteins
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Petka W.A., Hardin J.L., McGrath K.P., Wirtz D., Tirrell D.A. Reversible hydrogels from self-assembling artificial proteins. Science. 281:1998;389-392.
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Science
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Petka, W.A.1
Hardin, J.L.2
McGrath, K.P.3
Wirtz, D.4
Tirrell, D.A.5
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3
-
-
0032497322
-
A buried polar interaction can direct the relative orientation of helices in a coiled coil
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This is the first example of the redesign of the orientation of a coiled-coil structure from parallel to antiparallel
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Oakley M.G., Kim P.S. A buried polar interaction can direct the relative orientation of helices in a coiled coil. Biochemistry. 37:1998;12603-12610. This is the first example of the redesign of the orientation of a coiled-coil structure from parallel to antiparallel.
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(1998)
Biochemistry
, vol.37
, pp. 12603-12610
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Oakley, M.G.1
Kim, P.S.2
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4
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0032542575
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Metal ion induced folding of a de novo designed coiled-coil peptide
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Kohn W.D., Kay C.M., Sykes B.D., Hodges R.S. Metal ion induced folding of a de novo designed coiled-coil peptide. J Am Chem Soc. 120:1999;1124-1132.
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J Am Chem Soc
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, pp. 1124-1132
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Kohn, W.D.1
Kay, C.M.2
Sykes, B.D.3
Hodges, R.S.4
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5
-
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0032481038
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Selective amplification by auto- And cross-catalysis in a replicating peptide system
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This is the first paper to demonstrate conditional selection in a self-replicating peptide system
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Yao S., Ghosh I., Zutshi R., Chmielewski J. Selective amplification by auto- and cross-catalysis in a replicating peptide system. Nature. 396:1998;447-450. This is the first paper to demonstrate conditional selection in a self-replicating peptide system.
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(1998)
Nature
, vol.396
, pp. 447-450
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Yao, S.1
Ghosh, I.2
Zutshi, R.3
Chmielewski, J.4
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7
-
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0031906757
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Dynamic error correction in autocatalytic peptide networks
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This is the first example of error correction in peptide self-replication
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Sevrin K., Lee D.H., Martinez J.A., Vieth M., Ghadiri M.R. Dynamic error correction in autocatalytic peptide networks. Angew Chem Int Ed. 37:1998;126-128. This is the first example of error correction in peptide self-replication.
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(1998)
Angew Chem Int Ed
, vol.37
, pp. 126-128
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Sevrin, K.1
Lee, D.H.2
Martinez, J.A.3
Vieth, M.4
Ghadiri, M.R.5
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8
-
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0031746429
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From coiled coils to small globular proteins: Design of a native-like three-helix bundle
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Bryson J.W., Desjarlais J.R., Handel T.M., DeGrado W.F. From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci. 7:1998;1404-1414.
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Protein Sci
, vol.7
, pp. 1404-1414
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Bryson, J.W.1
Desjarlais, J.R.2
Handel, T.M.3
Degrado, W.F.4
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9
-
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0033545937
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Solution structure and dynamics of a de novo designed three-helix bundle protein
-
This is the first paper in which evidence is presented for the structure of a designed three-helix bundle protein
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Walsh S.T.R., Cheng H., Bryson J.W., Roder H., DeGrado W.F. Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc Natl Acad Sci USA. 96:1999;5486-5491. This is the first paper in which evidence is presented for the structure of a designed three-helix bundle protein.
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(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 5486-5491
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Walsh, S.T.R.1
Cheng, H.2
Bryson, J.W.3
Roder, H.4
Degrado, W.F.5
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10
-
-
0027416662
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Crystal structure of a synthetic triple-stranded α-helical bundle
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Lovejoy B., Choe S., Cascio D., McRorie D.K., DeGrado W.F., Eisenberg D. Crystal structure of a synthetic triple-stranded α-helical bundle. Science. 259:1993;1288-1293.
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Science
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Lovejoy, B.1
Choe, S.2
Cascio, D.3
McRorie, D.K.4
Degrado, W.F.5
Eisenberg, D.6
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11
-
-
0032509096
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QI, a trimeric coiled coil with buried polar residues
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This is the first exapmle of the use of X-ray crystallography to confirm that polar residues may be incorporated into the hydrophobic core of a coiled-coil
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QI, a trimeric coiled coil with buried polar residues. J Mol Biol. 284:1998;859-865. This is the first exapmle of the use of X-ray crystallography to confirm that polar residues may be incorporated into the hydrophobic core of a coiled-coil.
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(1998)
J Mol Biol
, vol.284
, pp. 859-865
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Eckert, D.M.1
Malashkevich, V.N.2
Kim, P.3
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12
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0032577018
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Native-like three-α-helix bundle protein from structure-based redesign: A novel maquette scaffold
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Johansson J.S., Gibney B.R., Skalicky J.J., Wand A.J., Dutton P.L.A. native-like three-α-helix bundle protein from structure-based redesign: a novel maquette scaffold. J Am Chem Soc. 120:1998;3881-3886.
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(1998)
J Am Chem Soc
, vol.120
, pp. 3881-3886
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Johansson, J.S.1
Gibney, B.R.2
Skalicky, J.J.3
Wand, A.J.4
Dutton, P.L.A.5
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13
-
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0032561793
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Metal ion induced self-assembly of a designed peptide into a triple-stranded α-helical bundle: A novel metal binding site in the hydrophobic core
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Suzuki K., Hiroaki H., Kohda D., Nakamura H., Tanaka T. Metal ion induced self-assembly of a designed peptide into a triple-stranded α-helical bundle: a novel metal binding site in the hydrophobic core. J Am Chem Soc. 120:1998;13008-13015.
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(1998)
J Am Chem Soc
, vol.120
, pp. 13008-13015
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Suzuki, K.1
Hiroaki, H.2
Kohda, D.3
Nakamura, H.4
Tanaka, T.5
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14
-
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0032584776
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The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils
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Dieckmann G.R., McRorie D.K., Lear J.D., Sharp K.A., DeGrado W.F., Pecoraro V.L. The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils. J Mol Biol. 280:1998;897-912.
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(1998)
J Mol Biol
, vol.280
, pp. 897-912
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Dieckmann, G.R.1
McRorie, D.K.2
Lear, J.D.3
Sharp, K.A.4
Degrado, W.F.5
Pecoraro, V.L.6
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15
-
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0033518594
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De novo design of protein function: Predictable structure-function relationships in synthetic redox proteins
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This was the first example of a designed three-helix bundle scaffold that was used for electron transfer processes
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Mutz M.W., Case M.A., Wishart J.F., Ghadiri M.R., McLendon G.L. De novo design of protein function: predictable structure-function relationships in synthetic redox proteins. J Am Chem Soc. 121:1999;858-859. This was the first example of a designed three-helix bundle scaffold that was used for electron transfer processes.
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(1999)
J Am Chem Soc
, vol.121
, pp. 858-859
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-
Mutz, M.W.1
Case, M.A.2
Wishart, J.F.3
Ghadiri, M.R.4
McLendon, G.L.5
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16
-
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0001141181
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Convergent approach to protein design. Metal ion-assisted spontaneous self-assembly of a polypeptide into a triple-helix bundle protein
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Ghadiri M.R., Soares C., Choi C.A. convergent approach to protein design. Metal ion-assisted spontaneous self-assembly of a polypeptide into a triple-helix bundle protein. J Am Chem Soc. 114:1992;825-831.
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J Am Chem Soc
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Ghadiri, M.R.1
Soares, C.2
Choi, C.A.3
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17
-
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0032553587
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High-resolution protein design with backbone freedom
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This paper describes the first example of the design and structure of a new protein fold: the right-handed coiled-coil
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Harbury P.B., Plecs J.J., Tidor B., Alber T., Kim P.S. High-resolution protein design with backbone freedom. Science. 282:1998;1462-1467. This paper describes the first example of the design and structure of a new protein fold: the right-handed coiled-coil.
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(1998)
Science
, vol.282
, pp. 1462-1467
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Harbury, P.B.1
Plecs, J.J.2
Tidor, B.3
Alber, T.4
Kim, P.S.5
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18
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17344363384
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Solution structure of α2D, a nativelike de novo designed protein
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This paper describes the first structural elucidation of a new design motif: the inverted U four-helix bundle
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Hill R.B., DeGrado W.F. Solution structure of α2D, a nativelike de novo designed protein. J Am Chem Soc. 120:1998;1138-1145. This paper describes the first structural elucidation of a new design motif: the inverted U four-helix bundle.
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(1998)
J Am Chem Soc
, vol.120
, pp. 1138-1145
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Hill, R.B.1
Degrado, W.F.2
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19
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0033516327
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Solution structure of a designed four-α-helix bundle maquette scaffold
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Skalicky J.J., Gibney B.R., Rabanal F., Urbauer R.J.B., Dutton P.L., Wand A.J. Solution structure of a designed four-α-helix bundle maquette scaffold. J Am Chem Soc. 120:1998;4941-4951.
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(1998)
J Am Chem Soc
, vol.120
, pp. 4941-4951
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Skalicky, J.J.1
Gibney, B.R.2
Rabanal, F.3
Urbauer, R.J.B.4
Dutton, P.L.5
Wand, A.J.6
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20
-
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0028824042
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Protein design: A hierarchic approach
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Bryson J.W., Betz S.F., Lu H.S., Suich D.J., Zhou H.X., O'Neil K.T., DeGrado W.F. Protein design: a hierarchic approach. Science. 270:1995;935-941.
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(1995)
Science
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Bryson, J.W.1
Betz, S.F.2
Lu, H.S.3
Suich, D.J.4
Zhou, H.X.5
O'Neil, K.T.6
Degrado, W.F.7
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21
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0032144119
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Functionalization of designed folded polypeptides
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Baltzer L. Functionalization of designed folded polypeptides. Curr Opin Struct Biol. 8:1998;466-470.
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(1998)
Curr Opin Struct Biol
, vol.8
, pp. 466-470
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Baltzer, L.1
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23
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0031587461
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Catalysis of hydrolysis and transesterification reactions of p-nitrophenyl esters by a designed helix-loop-helix dimer
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Broo K.S., Brive L., Ahlberg P., Baltzer L. Catalysis of hydrolysis and transesterification reactions of p-nitrophenyl esters by a designed helix-loop-helix dimer. J Am Chem Soc. 119:1997;11362-11372.
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(1997)
J Am Chem Soc
, vol.119
, pp. 11362-11372
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Broo, K.S.1
Brive, L.2
Ahlberg, P.3
Baltzer, L.4
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24
-
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0032490082
-
+-His pair and arginine transition state binding in catalysis of ester hydrolysis reactions by designed helix-loop-helix motifs
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A novel example of a catalytically active four-helix bundle is disclosed
-
+-His pair and arginine transition state binding in catalysis of ester hydrolysis reactions by designed helix-loop-helix motifs. J Am Chem Soc. 120:1998;4063-4068. A novel example of a catalytically active four-helix bundle is disclosed.
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(1998)
J Am Chem Soc
, vol.120
, pp. 4063-4068
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-
Broo, K.S.1
Nilsson, H.2
Nilsson, J.3
Flodberg, A.4
Baltzer, L.5
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25
-
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0032517335
-
Substrate recognition and saturation kinetics in de novo designed histidine-based four-helix bundle catalysts
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A novel example of a catalytically active four-helix bundle is disclosed
-
Broo K.S., Nilsson H., Nilsson J., Baltzer L. Substrate recognition and saturation kinetics in de novo designed histidine-based four-helix bundle catalysts. J Am Chem Soc. 120:1998;10287-10295. A novel example of a catalytically active four-helix bundle is disclosed.
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(1998)
J Am Chem Soc
, vol.120
, pp. 10287-10295
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-
Broo, K.S.1
Nilsson, H.2
Nilsson, J.3
Baltzer, L.4
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26
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0002689549
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A designed folded polypeptide model system that catalyzes the decarboxylation of oxaloacetate
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Allert M., Kjellstrand M., Broo K., Nilsson A., Baltzer L. A designed folded polypeptide model system that catalyzes the decarboxylation of oxaloacetate. J Chem Soc Perkin Trans. 2:1998;2271-2274.
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(1998)
J Chem Soc Perkin Trans
, vol.2
, pp. 2271-2274
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Allert, M.1
Kjellstrand, M.2
Broo, K.3
Nilsson, A.4
Baltzer, L.5
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28
-
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0032558105
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Differential binding of iron(III) and zinc(II) protoporphyrin IX to synthetic four-helix bundles
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This was the first example of a protein scaffold that could differentially bind a Zn(II) heme over a Fe(III) heme
-
Sharp R.E., Diers J.R., Bocian D.F., Dutton P.L. Differential binding of iron(III) and zinc(II) protoporphyrin IX to synthetic four-helix bundles. J Am Chem Soc. 120:1998;7103-7104. This was the first example of a protein scaffold that could differentially bind a Zn(II) heme over a Fe(III) heme.
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(1998)
J Am Chem Soc
, vol.120
, pp. 7103-7104
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-
Sharp, R.E.1
Diers, J.R.2
Bocian, D.F.3
Dutton, P.L.4
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29
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0030936312
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Design of a unique protein scaffold for maquettes
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Gibney B.R., Rabanal F., Skalicky J.J., Wand A.J., Dutton P.L. Design of a unique protein scaffold for maquettes. J Am Chem Soc. 119:1997;2323-2324.
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(1997)
J Am Chem Soc
, vol.119
, pp. 2323-2324
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Gibney, B.R.1
Rabanal, F.2
Skalicky, J.J.3
Wand, A.J.4
Dutton, P.L.5
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30
-
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0032169409
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Design, synthesis, and characterization of a photoactivatable flavocytochrome molecular maquette
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This was the first example of a protein scaffold that was designed for efficient electron transfer between a heme and a flavin moiety
-
Sharp R.E., Moser C.C., Rabanal F., Dutton P.L. Design, synthesis, and characterization of a photoactivatable flavocytochrome molecular maquette. Proc Natl Acad Sci USA. 95:1998;10465-10470. This was the first example of a protein scaffold that was designed for efficient electron transfer between a heme and a flavin moiety.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10465-10470
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-
Sharp, R.E.1
Moser, C.C.2
Rabanal, F.3
Dutton, P.L.4
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31
-
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0032578392
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Modular synthesis of de novo designed metalloproteins for light-induced electron transfer
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This is the first use of a template-assisted peptide scaffold to create a four-helix bundle protein with electron transfer properties
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Rau H.K., DeJonge N., Haehnel W. Modular synthesis of de novo designed metalloproteins for light-induced electron transfer. Proc Natl Acad Sci USA. 95:1998;11526-11531. This is the first use of a template-assisted peptide scaffold to create a four-helix bundle protein with electron transfer properties.
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(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11526-11531
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Rau, H.K.1
Dejonge, N.2
Haehnel, W.3
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32
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0542421525
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Foldamers: A manifesto
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Gellman S.H. Foldamers: a manifesto. Acc Chem Res. 31:1998;173-180.
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(1998)
Acc Chem Res
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, pp. 173-180
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Gellman, S.H.1
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35
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0027949973
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A chemical approach to elucidate the mechanism of transthyretin and beta-protein amyloid fibril formation
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Kelly J.W., Lansbury P.T. A chemical approach to elucidate the mechanism of transthyretin and beta-protein amyloid fibril formation. Amyloid. 1:1994;186-205.
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Amyloid
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Kelly, J.W.1
Lansbury, P.T.2
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38
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0033537730
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Evolution of a protein fold in vitro
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This paper discloses the first example in which switching the position of two adjacent amino acids switched the protein conformation to a new fold
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Cordes M.H.J., Walsh N.P., McKnight C.J., Sauer R.T. Evolution of a protein fold in vitro. Science. 284:1999;325-327. This paper discloses the first example in which switching the position of two adjacent amino acids switched the protein conformation to a new fold.
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(1999)
Science
, vol.284
, pp. 325-327
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Cordes, M.H.J.1
Walsh, N.P.2
McKnight, C.J.3
Sauer, R.T.4
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39
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0031851117
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A beta-sheet peptide inhibitor of E47 dimerization and DNA binding
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This was the first example of a β-sheet peptide that inhibited transcription factor dimerization and DNA binding by promoting a conformational shift
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Ghosh I., Chmielewski J. A beta-sheet peptide inhibitor of E47 dimerization and DNA binding. Chem Biol. 5:1998;439-445. This was the first example of a β-sheet peptide that inhibited transcription factor dimerization and DNA binding by promoting a conformational shift.
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(1998)
Chem Biol
, vol.5
, pp. 439-445
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Ghosh, I.1
Chmielewski, J.2
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40
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0032979894
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Structure-function relationship in a beta-sheet peptide inhibitor of E47 dimerization and DNA binding
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Ghosh I., Issac R., Chmielewski J. Structure-function relationship in a beta-sheet peptide inhibitor of E47 dimerization and DNA binding. Bioorg Med Chem. 7:1999;61-66.
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(1999)
Bioorg Med Chem
, vol.7
, pp. 61-66
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Ghosh, I.1
Issac, R.2
Chmielewski, J.3
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41
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0033591693
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Regulation of alpha/beta folding of a designed peptide by haem binding
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A novel designed peptide that demonstrates a helix to sheet conformational switch is disclosed
-
Sakamoto S., Obataya I., Ueno A., Mihara H. Regulation of alpha/beta folding of a designed peptide by haem binding. Chem Commun. 1999;1111-1112. A novel designed peptide that demonstrates a helix to sheet conformational switch is disclosed.
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(1999)
Chem Commun
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Sakamoto, S.1
Obataya, I.2
Ueno, A.3
Mihara, H.4
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42
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0031798017
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Design of a peptide undergoing alpha-beta structural transition and amyloid fibrillogenesis by the introduction of a hydrophobic defect
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A novel designed peptide that demonstrates a helix to sheet conformational switch, and which formed amyloid-like fibrils is disclosed
-
Takahashi Y., Ueno A., Mihara H. Design of a peptide undergoing alpha-beta structural transition and amyloid fibrillogenesis by the introduction of a hydrophobic defect. Chem Eur J. 4:1998;2475-2484. A novel designed peptide that demonstrates a helix to sheet conformational switch, and which formed amyloid-like fibrils is disclosed.
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(1998)
Chem Eur J
, vol.4
, pp. 2475-2484
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Takahashi, Y.1
Ueno, A.2
Mihara, H.3
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43
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0033015586
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Optimization of hydrophobic domains in peptides that undergo transformation from alpha-helix to beta-fibril
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Takahashi Y., Ueno A., Mihara H. Optimization of hydrophobic domains in peptides that undergo transformation from alpha-helix to beta-fibril. Bioorg Med Chem. 7:1999;177-185.
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(1999)
Bioorg Med Chem
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Takahashi, Y.1
Ueno, A.2
Mihara, H.3
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44
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0031926859
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Structural cassettes mutagenesis in a de novo designed protein: Proof of a novel concept for examining protein folding and stability
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A novel coiled-coil cassette that was developed to convert β-sheet peptides into helical structures is described
-
Kwok S.C., Tripet B., Man J.H., Chana M.S., Lavigne P., Mant C.T., Hodges R.S. Structural cassettes mutagenesis in a de novo designed protein: proof of a novel concept for examining protein folding and stability. Biopolymers. 47:1998;101-123. A novel coiled-coil cassette that was developed to convert β-sheet peptides into helical structures is described.
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(1998)
Biopolymers
, vol.47
, pp. 101-123
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-
Kwok, S.C.1
Tripet, B.2
Man, J.H.3
Chana, M.S.4
Lavigne, P.5
Mant, C.T.6
Hodges, R.S.7
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