Inhibition of UDP-Gal mutase and mycobacterial galactan biosynthesis by pyrrolidine analogues of galactofuranose

Tetrahedron Letters

Volumn 38, Issue 38, 1997, Pages 6733-6736

  Lee, Richard E ^a   Smith, Martin D ^a   Nash, Robert J ^b   Griffiths, Rhodri C ^b   McNeil, Michael ^c   Grewal, Ravinder K ^c   Yan, Wenxin ^c   Besra, Gurdyal S ^c   Brennan, Patrick J ^c   Fleet, George W J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

^c Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTAN; MUTASE; PYRROLIDINE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI K 12; MYCOBACTERIUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EID: 0030852401     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01539-6     Document Type: Article

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19. The assays were conducted as in reference with UDP-[14C]Gal replacing UDP-[14C]GlcNAc, and with subsequent isolation and counting of the polymer. The amount of inhibition is dependent on the protein concentration.
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22. All isolable new compounds have satisfactory CHN microanalytical or high resolution mass spectral data. This work has been supported by GlaxoWellcome and EPSRC, and by Health Service Grants NIAID, NIH U19-AI 40972 and AI-33706.